| In vitro: |
| Industrial Crops and Products, 2016, 94:658-664. | | Antiphytoviral activity of alkaloids from Cephalotaxus sinensis[Reference: WebLink] | The evaluation of pesticidal activity and the isolation of plant allelochemicals can lead to the discovery of new pesticides.
METHODS AND RESULTS:
This study confirmed that Cephalotaxus sinensis, an important Chinese medicinal species, has excellent activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) both indoors and outdoors; its control of the TMV is comparable to that of a commercialized antiviral agent (VA; active ingredient = a mixture of moroxydine hydrochloride and copper acetate). Using bioassay-guided fractionation, we isolated eight active alkaloids, which were identified as drupacine, 11-hydroxycephalotaxine, cephalancetine A, isocephalotaxine, cephalotaxine β-N-oxide, 4-Hydroxycephalotaxine, wilsonine and cephalotaxine.
CONCLUSIONS:
At the same dosage, the inactivation activities against TMV were not significantly different among drupacine, 11-hydroxycephalotaxine, cephalotaxine and VA (inhibition ratio = 50.76% to 53.41%). |
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