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  • 雌马酚

    4',7-Isoflavandiol

    雌马酚
    产品编号 CFN90723
    CAS编号 531-95-3
    分子式 = 分子量 C15H14O3 = 242.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Glycine max.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    雌马酚 CFN90723 531-95-3 10mg QQ客服:1457312923
    雌马酚 CFN90723 531-95-3 20mg QQ客服:1457312923
    雌马酚 CFN90723 531-95-3 50mg QQ客服:1457312923
    雌马酚 CFN90723 531-95-3 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Bioengineering2023, 10(10), 1113.
  • Phytochemistry.2021, 181:112539.
  • Appl. Sci.2020, 10(20), 7323.
  • Front Pharmacol.2019, 10:1025
  • J Cell Biochem.2022, 123(7):1222-1236.
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  • Chinese Journal of Tissue Engineering Research2024, 28(8):1149-1154.
  • J Ethnopharmacol.2017, 198:91-97
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  • Biomedicines.2024, 12(3):495.
  • Molecules2022, 27(3),1140.
  • Food Chem.2024, 436:137768.
  • Food Research2022, 6(6): 30-38.
  • J Ethnopharmacol.2019, 244:112074
  • Cell Biochem Funct.2018, 36(6):303-311
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  • Int J Mol Med.2020, 45(5):1514-1524.
  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • Molecules.2021, 26(3):695.
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  • Bioorg Chem.2024, 145:107184.
  • ...
  • 生物活性
    Description: 4',7-Isoflavandiol, an estrogen metabolite, affects the ability of soy nuts to improve cardiovascular risk factors. 4',7-Isoflavandiol is a potential anticancer agent against HeLa, with possible mechanisms involved in ROS generation and mitochondrial membrane alteration; it may advance breast cancer potential via up-regulation of the eukaryotic initiation factor 4GI (eIF4GI).
    Targets: c-Myc | ROS | MMP(e.g.TIMP) | Bcl-2/Bax | Caspase | Estrogen receptor
    In vitro:
    Anticancer Res. 2014 Sep;34(9):4985-92.
    Equol induces mitochondria-mediated apoptosis of human cervical cancer cells.[Pubmed: 25202081]
    The present study aimed to investigate anticancer properties of 4',7-Isoflavandiol and demonstrate its underlying mechanisms of action in human cervical cancer HeLa cells.
    METHODS AND RESULTS:
    Inhibition of cell viability was examined by 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was evaluated by observation of apoptotic cell morphology, and an increase of annexin-V(+) cells. Western blotting was used to examine apoptosis-related proteins. Flow cytometry was used to measure mitochondrial membrane potential (MMP) and reactive oxygen species (ROS). 4',7-Isoflavandiol treatment inhibited HeLa cell proliferation in dose- and time-dependent manner. 4',7-Isoflavandiol-induced apoptotic cell death was accompanied by the activation of caspases, and alteration of MMP and mitochondrial membrane proteins; 4',7-Isoflavandiol also rapidly triggered ROS production. Pre-treatment with N-acetylcysteine blocked loss of MMP, caused increase of Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio, caspase-8 activation, and apoptosis induced by equol.
    CONCLUSIONS:
    4',7-Isoflavandiol is a potential anticancer agent against HeLa, with possible mechanisms involved in ROS generation and mitochondrial membrane alteration.
    In vivo:
    Metabolism. 2015 Feb;64(2):236-43.
    Effect of soy nuts and equol status on blood pressure, lipids and inflammation in postmenopausal women stratified by metabolic syndrome status.[Pubmed: 25441251]
    Soy has been associated with lower risk of cardiovascular disease in Asian countries which consume daily soy. Our study examined whether production of 4',7-Isoflavandiol , an estrogen metabolite, affected the ability of soy nuts to improve cardiovascular risk factors.
    METHODS AND RESULTS:
    Sixty postmenopausal women participated in a randomized, controlled, crossover trial of a Therapeutic Lifestyle Changes (TLC) diet alone and a TLC diet in which 0.5 cup of soy nuts (25 g of soy protein and 101 mg of aglycone isoflavones) replaced 25 g of nonsoy protein daily. Each diet was followed for 8 weeks at the end of which blood pressure (BP), lipid levels, adhesion molecules and inflammatory markers were measured. Women with MetS had significantly higher baseline body mass index (BMI), BP, triglycerides (TG), and soluble intercellular adhesion molecule (sICAM) than women without MetS. In women with MetS on the soy diet, significant reductions in diastolic BP (7.7%; P=0.02), TG (22.9%; P=0.02), C-reactive protein (CRP) (21.4%; P=0.01) and sICAM (7.3%; P=0.03) were noted among equol producers compared to levels on the TLC diet. No significant changes were noted in 4',7-Isoflavandiol nonproducers. Similarly, in women without MetS, only 4',7-Isoflavandiol producers had significant reductions in diastolic BP (3.3%, P=0.02) and CRP (30%, P=0.04). In contrast to women with MetS, TG and sICAM levels were not affected in women without MetS, a finding possibly related to lower baseline levels.
    CONCLUSIONS:
    Cardiovascular risk reduction with soy nuts is not uniform and may be greater among producers of 4',7-Isoflavandiol..
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
    5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
    10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
    50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
    100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    垂崖豆藤异黄烷醌; Pendulone CFN91031 69359-09-7 C17H16O6 = 316.31 5mg QQ客服:215959384
    7,2'-羟基-3',4'-二甲氧基异黄烷; Isomucronulatol CFN90839 52250-35-8 C17H18O5 = 302.3 10mg QQ客服:2056216494
    黄芪异黄烷苷; Isomucronulatol 7-O-glucoside CFN93256 94367-43-8 C23H28O10 = 464.5 20mg QQ客服:2056216494
    鱼鳔槐氢醌; Colutehydroquinone CFN91022 181311-16-0 C18H20O6 = 332.35 10mg QQ客服:3257982914
    Haginin A; Haginin A CFN96550 74174-29-1 C17H16O5 = 300.31 5mg QQ客服:1413575084
    降香黄烃; Odoriflavene CFN91023 101153-41-7 C17H16O5 = 300.31 5mg QQ客服:2056216494
    Bidwillol A; Bidwillol A CFN97992 161099-42-9 C21H22O4 = 338.4 5mg QQ客服:1413575084
    Erythbidin A; Erythbidin A CFN96547 210050-83-2 C20H20O4 = 324.37 5mg QQ客服:2159513211
    光果甘草素; Glabrene CFN96402 60008-03-9 C20H18O4 = 322.4 5mg QQ客服:1413575084
    Dehydroglyasperin C; Dehydroglyasperin C CFN96483 199331-35-6 C21H22O5 = 354.4 5mg QQ客服:1413575084

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