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  • 4,4'-O-二甲基鞣花酸

    • 4,4'-O-二甲基鞣花酸

    4,4'-Di-O-methylellagic acid

    4,4'-O-二甲基鞣花酸
    		产品编号 CFN92805
    CAS编号 3374-77-4
    分子式 = 分子量 C16H10O8 = 330.0
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The peels of Punica granatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,4'-O-二甲基鞣花酸 CFN92805 3374-77-4 1mg QQ客服：1413575084
    4,4'-O-二甲基鞣花酸 CFN92805 3374-77-4 5mg QQ客服：1413575084
    4,4'-O-二甲基鞣花酸 CFN92805 3374-77-4 10mg QQ客服：1413575084
    4,4'-O-二甲基鞣花酸 CFN92805 3374-77-4 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Planta Med.2016, 82(13):1208-16
  • Biomed Pharmacother.2023, 163:114785.
  • Molecules.2017, 22(2)
  • Braz J Med Biol Res. 2016, 49(7)
  • Mol Biol Rep.2023, 50(5):4029-4038.
  • Antioxidants (Basel).2022, 11(10):1929.
  • Chung Shan Medical University2020, US20200323790A1
  • GENENCELL2023, 25:4356740
  • Cancers (Basel).2021, 13(6):1432.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • University of Central Lancashire2017, 20472
  • Separations2021, 8(7),90.
  • Front Pharmacol.2021, 12:764297.
  • Int J Mol Med.2016, 37(2):501-8
  • Journal of functional foods2018, 171-182
  • Planta Med.2023, 2192-2281
  • Food Science and Human Wellness2022, 11(4):965-974
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Jurnal Ilmu Pertanian Indonesia2023, 28(4):525-533.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Pharmacia2024, 71:1-9.
  • Chem. of Vegetable Raw Materials2020, 97-105
  • FEBS Lett.2021, 595(20):2608-2615.
  • ...
    • 生物活性
    Description: 4,4'-di-O-methylellagic acid is the most effective compound in the inhibition of colon cancer cell proliferation.
    Targets: Wnt/β-catenin
    In vitro:
    J Pharmacol Exp Ther. 2015 May;353(2):433-44.
    The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.[Pubmed: 25758919]
    Ellagic acid (EA) and some derivatives have been reported to inhibit cancer cell proliferation, induce cell cycle arrest, and modulate some important cellular processes related to cancer. This study aimed to identify possible structure-activity relationships of EA and some in vivo derivatives in their antiproliferative effect on both human colon cancer and normal cells, and to compare this activity with that of other polyphenols.
    METHODS AND RESULTS:
    Our results showed that 4,4'-di-O-methylellagic acid (4,4'-DiOMEA) was the most effective compound in the inhibition of colon cancer cell proliferation. 4,4'-DiOMEA was 13-fold more effective than other compounds of the same family. In addition, 4,4'-DiOMEA was very active against colon cancer cells resistant to the chemotherapeutic agent 5-fluoracil, whereas no effect was observed in nonmalignant colon cells. Moreover, no correlation between antiproliferative and antioxidant activities was found, further supporting that structure differences might result in dissimilar molecular targets involved in their differential effects. Finally, microarray analysis revealed that 4,4'-DiOMEA modulated Wnt signaling, which might be involved in the potential antitumor action of this compound.
    CONCLUSIONS:
    Our results suggest that structural-activity differences between EA and 4,4'-DiOMEA might constitute the basis for a new strategy in anticancer drug discovery based on these chemical modifications.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0303 mL 15.1515 mL 30.303 mL 60.6061 mL 75.7576 mL
    5 mM 0.6061 mL 3.0303 mL 6.0606 mL 12.1212 mL 15.1515 mL
    10 mM 0.303 mL 1.5152 mL 3.0303 mL 6.0606 mL 7.5758 mL
    50 mM 0.0606 mL 0.303 mL 0.6061 mL 1.2121 mL 1.5152 mL
    100 mM 0.0303 mL 0.1515 mL 0.303 mL 0.6061 mL 0.7576 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    石榴皮鞣素; Punicalin CFN98113 65995-64-4 C34H22O22 = 782.52 20mg QQ客服：1457312923
    安石榴甙； 安石榴苷; Punicalagin CFN99938 65995-63-3 C48H28O30 = 1084.72 20mg QQ客服：215959384
    诃子鞣质; Terchebulin CFN92297 132854-40-1 C48H28O30 = 1084.7 5mg QQ客服：1457312923
    鞣花酸-4-O-beta-D-吡喃木糖苷; Ellagic acid-4-O-beta-D-xylopyranoside CFN95618 139163-18-1 C19H14O12 = 434.3 5mg QQ客服：2159513211
    Eschweilenol C; Eschweilenol C CFN95363 211371-02-7 C20H16O12 = 448.3 10mg QQ客服：1413575084
    3-甲基鞣花酸; 3-Methyl ellagic acid CFN70390 51768-38-8 C15H8O8 = 316.2 5mg QQ客服：1413575084
    鞣花酸-4-O-alpha-L-呋喃阿拉伯糖苷; Ellagic acid 4-O-alpha-L-arabinofuranoside CFN95613 358617-39-7 C19H14O12 = 434.3 5mg QQ客服：215959384
    蛇莓苷A; Ducheside A CFN99833 176665-78-4 C20H16O12 = 448.3 5mg QQ客服：3257982914
    3-O-甲基鞣花酸-4'-O-鼠李糖苷; 3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside CFN95228 51768-39-9 C21H18O12 = 462.4 5mg QQ客服：1413575084
    3-O-甲基鞣花酸-3'-O-鼠李糖苷; 3-O-Methylellagic acid 3'-O-alpha-rhamnopyranoside CFN95375 352280-34-3 C21H18O12 = 462.4 5mg QQ客服：2159513211

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