Info: Read More
  • 中药标准品生产商,产品定制服务
  • 乙酰基-11-羟基-beta-乳香酸

    3-O-Acetyl-11-hydroxy-beta-boswellic acid

    乙酰基-11-羟基-beta-乳香酸
    产品编号 CFN91039
    CAS编号 146019-25-2
    分子式 = 分子量 C32H50O5 = 514.74
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Boswellia carterii Birdw.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰基-11-羟基-beta-乳香酸 CFN91039 146019-25-2 1mg QQ客服:2159513211
    乙酰基-11-羟基-beta-乳香酸 CFN91039 146019-25-2 5mg QQ客服:2159513211
    乙酰基-11-羟基-beta-乳香酸 CFN91039 146019-25-2 10mg QQ客服:2159513211
    乙酰基-11-羟基-beta-乳香酸 CFN91039 146019-25-2 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Celltrion Chemical Research Institute (Korea)
  • Monash University (Australia)
  • University of Cincinnati (USA)
  • Texas A&M University (USA)
  • Washington State University (USA)
  • University of Perugia (Italy)
  • Heidelberg University (Germany)
  • Florida International University (USA)
  • Anna University (India)
  • Michigan State University (USA)
  • Kyung Hee University (Korea)
  • Universidade Católica Portuguesa (Portugal)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • MTT Agrifood Research Finland (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JMSACL2023, 09.002
  • J Ethnopharmacol.2017, 196:75-83
  • Bioorg Chem.2024, 145:107184.
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Hortic Res.2023, 10(4):uhad039.
  • Trop J Nat Prod Res, February2023, 7(2):2371-2381
  • LWT2021, 147:111620.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • BMC Cancer. 2021, 21(1):91.
  • J. Traditional Thai Medical Res. 2022,8(1):1-14.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • Biomol Ther (Seoul).2024, 32(2):214-223.
  • Food Chem.2020, 332:127412
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Appl. Sci.2021, 11(19),9343.
  • Molecules.2022, 27(7):2116.
  • Foods.2023, 12(12):2412.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • Toxicol Mech Methods.2021, 1-12.
  • Applied Biological Chemistry2022, 65(12)
  • J Cell Mol Med.2023, jcmm.18071.
  • ...
  • 生物活性
    Description: 3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
    Targets: LOX
    In vitro:
    Daru. 2013 Jan 2;21(1):2.
    Urease inhibitory activities of β-boswellic acid derivatives.[Pubmed: 23351363 ]
    Boswellia carterii have been used in traditional medicine for many years for management different gastrointestinal disorders. In this study, we wish to report urease inhibitory activity of four isolated compound of boswellic acid derivative.
    METHODS AND RESULTS:
    4 pentacyclic triterpenoid acids were isolated from Boswellia carterii and identified by NMR and Mass spectroscopic analysis (compounds 1, 3-O-acetyl-9,11-dehydro-β-boswellic acid; 2, 3-O-Acetyl-11-hydroxy-beta-boswellic acid ; 3. 3-O- acetyl-11-keto-β-boswellic acid and 4, 11-keto-β-boswellic acid. Their inhibitory activity on Jack bean urease were evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between isolated compounds and urease enzyme. It was found that compound 1 has the strongest inhibitory activity against Jack bean urease (IC50 = 6.27 ± 0.03 μM), compared with thiourea as a standard inhibitor (IC50 = 21.1 ± 0.3 μM).
    CONCLUSIONS:
    The inhibition potency is probably due to the formation of appropriate hydrogen bonds and hydrophobic interactions between the investigated compounds and urease enzyme active site and confirms its traditional usage.
    J Nat Prod. 2000 Aug;63(8):1058-61.
    Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.[Pubmed: 10978197]
    Pentacyclic triterpenes from the 11-keto-boswellic acid series were identified as the active principal ingredients of Boswellia resin, inhibiting the key enzyme of leukotriene biosynthesis, 5-lipoxygenase (5-LO). Of the genuine boswellic acids hitherto characterized, 3-O-acetyl-11-keto-beta-boswellic acid, AKBA (1), proved to be the most potent inhibitor of 5-LO.
    METHODS AND RESULTS:
    In the course of purification of further boswellic acid derivatives from Boswellia resin, we observed the degradation of the natural compound 3-O-Acetyl-11-hydroxy-beta-boswellic acid (2) to the thermodynamically more stable product 3-O-acetyl-9, 11-dehydro-beta-boswellic acid (4). The metastable intermediate of this conversion, under moderate conditions of workup in methanolic solutions, was identified as 3-O-acetyl-11-methoxy-beta-boswellic acid (3). The novel artifactual boswellic acid derivatives inhibited 5-LO product formation in intact cells with different characteristics: 4 almost totally abolished 5-LO activity, with an IC(50) of 0.75 microM, whereas 3 and 9,11-dehydro-beta-boswellic acid (5), the deacetylated analogue of 4, were incomplete inhibitors.
    CONCLUSIONS:
    The data suggest that the conditions chosen for the workup of Boswellia extracts could significantly influence the potency of their biological actions and their potential therapeutic effectiveness.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9427 mL 9.7136 mL 19.4273 mL 38.8546 mL 48.5682 mL
    5 mM 0.3885 mL 1.9427 mL 3.8855 mL 7.7709 mL 9.7136 mL
    10 mM 0.1943 mL 0.9714 mL 1.9427 mL 3.8855 mL 4.8568 mL
    50 mM 0.0389 mL 0.1943 mL 0.3885 mL 0.7771 mL 0.9714 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3885 mL 0.4857 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Ethyl ganoderate J; Ethyl ganoderate J CFN92576 1189555-95-0 C32H46O7 = 542.7 5mg QQ客服:3257982914
    Isosalviamine A; Isosalviamine A CFN92645 878475-29-7 C19H13NO2 = 287.3 5mg QQ客服:1457312923
    乙酸庚酯; Heptyl acetate CFN70027 112-06-1 C9H18O2 = 158.2 20mg QQ客服:1413575084
    莫诺苷; Morroniside CFN98161 25406-64-8 C17H26O11 = 406.38 20mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产