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  • 麦斯明

    Myosmine

    麦斯明
    产品编号 CFN70399
    CAS编号 532-12-7
    分子式 = 分子量 C9H10N2 = 146.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Equisetum hyemale L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    麦斯明 CFN70399 532-12-7 10mg QQ客服:1457312923
    麦斯明 CFN70399 532-12-7 20mg QQ客服:1457312923
    麦斯明 CFN70399 532-12-7 50mg QQ客服:1457312923
    麦斯明 CFN70399 532-12-7 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • University of Padjajaran (Indonesia)
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  • Sri Ramachandra University (India)
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  • Shanghai Institute of Organic Chemistry (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Int J Mol Sci.2018, 19(9):E2601
  • J Ethnopharmacol.2017, 198:87-90
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  • Tumour Biol.2015, 36(12):9385-93
  • Industrial Crops and Products2021, 163:113313.
  • Molecules.2020, 25(21):5087.
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  • ...
  • 生物活性
    Description: Myosmine exerts significant genotoxic effects in esophageal cells under conditions which may prevail in GERD such as increased oxidative and nitrosative stress resulting from chronic inflammation. Myosmine shows pro-oxidant effects, which comparable with those of nicotine.
    Targets: DNA | COX-2
    In vitro:
    Toxicology, 2006, 222(1-2):71-79.
    Genotoxic effects of myosmine in a human esophageal adenocarcinoma cell line.[Reference: WebLink]
    The incidence of esophageal adenocarcinoma is rapidly rising in Western populations. Gastroesophageal reflux disease (GERD) is thought to be one of the most important risk factors. However, the mechanisms by which GERD enhances tumor formation at the gastroesophageal junction are not well understood. Myosmine is a tobacco alkaloid which has also a wide spread occurrence in human diet. It is readily activated by nitrosation and peroxidation giving rise to the same hydroxypyridylbutanone-releasing DNA adducts as the esophageal carcinogen N'-nitrosonornicotine. Therefore, the genotoxicity of myosmine was tested in a human esophageal adenocarcinoma cell line (OE33). DNA damage was assessed by single-cell gel electrophoresis (Comet assay).
    METHODS AND RESULTS:
    DNA strand breaks, alkali labile sites and incomplete excision repair were expressed using the Olive tail moment (OTM). The Fapy glycosylase (Fpg) enzyme was incorporated into the assay to reveal additional oxidative DNA damage. DNA migration was determined after incubation of the cells for 1-24h. Under neutral conditions high myosmine concentrations of 25-50mM were necessary to elicit a weak genotoxic effect. At pH 6 genotoxicity was clearly enhanced giving a significant increase of OTM values at 5mM myosmine. Lower pH values could not be tested because of massive cytotoxicity even in the absence of myosmine. Co-incubation of 25 mM myosmine with 1mM H(2)O(2) for 1h significantly enhanced the genotoxicity of H(2)O(2) but not the oxidative lesions additionally detected with the Fpg enzyme. In the presence of the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) a dose-dependent significant genotoxic effect was obtained with 1-10mM myosmine after 4h incubation. NS-398, a selective inhibitor of cyclooxygenase 2, did not affect the SIN-1 stimulated genotoxicity of myosmine. Finally, the 23 h repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA lesions was significantly inhibited in the presence of 10mM myosmine.
    CONCLUSIONS:
    In conclusion, myosmine exerts significant genotoxic effects in esophageal cells under conditions which may prevail in GERD such as increased oxidative and nitrosative stress resulting from chronic inflammation.
    Croatica Chemica Acta,2011,84(3):355-359.
    Flow Cytometric Analysis of the Influence of Myosmine on the Cell Cycle.[Reference: WebLink]
    Myosmine (3-(1-pyrrolin-2-yl)pyridine) is an alkaloid found in tobacco as well as various staple foods, fruits and vegetables. Myosmine has recently been suspected to be a tobacco-independent carcinogenic source.
    METHODS AND RESULTS:
    Using cell flow cytometry, we have examined the influence of myosmine on the cell cycle of murine erythroleukemia (MEL) cells in vitro and have compared this with its effects on murine bone marrow cells in vivo. Myosmine at low concentrations inhibited cell proliferation dose dependently; while at concentrations close to 300 mu mol dm(-3) it acted in a cytostatic fashion, that is, it increased the percentage of cells in the S and G2/M phases. At doses of 350-400 mu mol dm(-3) myosmine induced apoptosis and the hypoploid fraction. In vivo intraperitoneal injection of mice with 100 mg/kg of myosmine resulted in a statistically significant increase in the percentage of cells in S phase; i.e. from 13.75 to 18.22%. The percentage of bone marrow cells in the G2/M phase increased from 6.79 to 8.93 % in treated mice compared to controls.
    CONCLUSIONS:
    All of these results are in agreement with the hypothesis that myosmine possesses genotoxic potential.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.8399 mL 34.1997 mL 68.3995 mL 136.7989 mL 170.9986 mL
    5 mM 1.368 mL 6.8399 mL 13.6799 mL 27.3598 mL 34.1997 mL
    10 mM 0.684 mL 3.42 mL 6.8399 mL 13.6799 mL 17.0999 mL
    50 mM 0.1368 mL 0.684 mL 1.368 mL 2.736 mL 3.42 mL
    100 mM 0.0684 mL 0.342 mL 0.684 mL 1.368 mL 1.71 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
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    柴胡皂苷B4; Saikosaponin B4 CFN93258 58558-09-1 C43H72O14 = 813.03 5mg QQ客服:2056216494
    Crotaleschenine; Crotaleschenine CFN00365 120154-95-2 C16H23NO5 = 309.36 5mg QQ客服:1457312923
    赤藓红; Erythrosin B CFN91670 568-63-8 C20H6I4Na2O5 = 879.86 5mg QQ客服:1457312923
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