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  • 3-表齐墩果酸

    • 3-表齐墩果酸

    3-Epioleanolic acid

    3-表齐墩果酸
    		产品编号 CFN92068
    CAS编号 25499-90-5
    分子式 = 分子量 C30H48O3 = 456.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Stauntonia hexaphylla
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-表齐墩果酸 CFN92068 25499-90-5 1mg QQ客服：2056216494
    3-表齐墩果酸 CFN92068 25499-90-5 5mg QQ客服：2056216494
    3-表齐墩果酸 CFN92068 25499-90-5 10mg QQ客服：2056216494
    3-表齐墩果酸 CFN92068 25499-90-5 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Eur J Pharmacol.2018, 832:96-103
  • Food Chem.2019, 279:80-87
  • J. ISSAAS2023, 29(2):36-51.
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  • Chem Biodivers.2023, 20(10):e202300741.
  • Nutr Res Pract2019, 13:e45
  • The Catharanthus Genome2022,35-83.
  • Research Square2021, March 3rd.
  • Agronomy2022, 12(10), 2426.
  • J Ethnopharmacol.2024, 318(Pt B):116961.
  • Int J Mol Sci.2018, 19(2)
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Phytomedicine.2024, 129:155645.
  • Molecules.2021, 26(16):4722.
  • Molecules.2020, 25(23):5609.
  • Molecules.2021, 26(4):816.
  • Cell Chem Biol.2019, 26(1):27-34
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Front Pharmacol.2022, 13:806869.
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  • Int J Biol Sci.2023, 19(10):3077-3098.
  • ...
    • 生物活性
    Description: 3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.
    Targets: AChR
    In vitro:
    J Pharm Biomed Anal. 2000 Dec;24(1):133-45.
    The uterotonic activity of compounds isolated from the supercritical fluid extract of Ekebergia capensis.[Pubmed: 11108547]
    The wood of Ekebergia capensis Sparrm. is used by the local Zulu community in KwaZulu-Natal Province, South Africa to facilitate childbirth.
    METHODS AND RESULTS:
    In this investigation, the uterotonic properties of extracts from this tree were evaluated using both pregnant and non-pregnant guinea pig uterine smooth muscle in vitro. The extracts were prepared using water modified supercritical carbon dioxide at 400 atm and 80 degrees C. As samples of these extracts displayed positive results when screened for uterotonic activity, gravity column chromatography followed by NMR spectroscopy was performed in an attempt to isolate and elucidate the structures of the compounds that were present in the extract. The extract yielded five known compounds of which only two, viz. oleanonic acid and 3-Epioleanolic acid, displayed uterotonic activity. Receptor binding assays were subsequently performed with 3-Epioleanolic acid to ascertain its mode of action. Bradykinin (30 ng/100 microl) and acetylcholine (1 microg/100 microl) were used as the B2 and cholinergic receptor agonists respectively with icatibant (HOE 140) (30 ng/100 microl) and atropine (60 micro/100 microl) as their corresponding antagonists. 3-Epioleanolic acid was observed to mediate its effect through the cholinergic receptor.
    CONCLUSIONS:
    The results of this study show that two compounds from the extract of this tree possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.
    In vivo:
    Phytother Res. 2000 Sep;14(6):463-5.
    Antiinflammatory activity and chemical composition of extracts of Verbena officinalis.[Pubmed: 10960904]

    METHODS AND RESULTS:
    In an attempt to locate the biologically active fraction(s) of the plant Verbena officinalis Linn. (Verbenaceae), a preliminary screening of successive petroleum ether, chloroform and methanol extracts of aerial parts for antiinflammatory activity using carrageenan paw oedema model was carried out. All three extracts were found to exhibit antiinflammatory activity with the chloroform extract being the most active. Chemical investigations of petroleum ether and chloroform extracts led to the isolation of beta-sitosterol, ursolic acid, oleanolic acid, 3-epiursolic acid, 3-Epioleanolic acid, and minor triterpenoids of derivatives of ursolic acid and oleanolic acids.
    CONCLUSIONS:
    Chromatographic purification of the methanol extract yielded two iridoid glucosides, verbenalin and hastatoside, a phenylpropanoid glycoside, verbascoside and beta-sitosterol-D-glucoside.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1896 mL 10.9481 mL 21.8962 mL 43.7924 mL 54.7405 mL
    5 mM 0.4379 mL 2.1896 mL 4.3792 mL 8.7585 mL 10.9481 mL
    10 mM 0.219 mL 1.0948 mL 2.1896 mL 4.3792 mL 5.4741 mL
    50 mM 0.0438 mL 0.219 mL 0.4379 mL 0.8758 mL 1.0948 mL
    100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4379 mL 0.5474 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid CFN96050 97534-10-6 C39H54O6 = 618.9 5mg QQ客服：2159513211
    3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid; 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid CFN95710 469895-08-7 C32H50O5 = 514.8 5mg QQ客服：1413575084
    3-氧代-12-烯-28-齐墩果酸; 3-oxo-Olean-12-en-28-oic acid CFN92194 17990-42-0 C30H46O3 = 454.7 20mg QQ客服：2159513211
    3-Keto-齐墩果酸-28-甲酯; 3-Oxo-olean-12-en-28-oic acid methyl ester CFN91814 1721-58-0 C31H48O3 = 468.7 5mg QQ客服：2056216494
    Virgatic acid; Virgatic acid CFN96451 14356-51-5 C30H46O4 = 470.70 5mg QQ客服：2159513211
    刺囊酸; Echinocystic acid CFN98812 510-30-5 C30H48O4 = 472.7 20mg QQ客服：1457312923
    3alpha-木通萜酸; 3alpha-Akebonoic acid CFN99067 104777-61-9 C29H44O3 = 440.7 5mg QQ客服：3257982914
    Sebiferenic acid; Sebiferenic acid CFN97523 94390-09-7 C30H48O4 = 472.7 5mg QQ客服：2159513211
    3,4-开环-齐墩果-12-烯-4-醇-3,28-二酸; 3,4-seco-Olean-12-en-4-ol-3,28-dioic acid CFN96849 182249-69-0 C30H48O5 = 488.70 5mg QQ客服：3257982914
    3-氧代-24-去甲齐墩果-12-烯-28-酸 ; Hedragonic acid CFN96602 466-02-4 C29H44O3 = 440.66 5mg QQ客服：215959384

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