3-表齐墩果酸

3-Epioleanolic acid

	产品编号	CFN92068
	CAS编号	25499-90-5
	分子式 = 分子量	C₃₀H₄₈O₃ = 456.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Stauntonia hexaphylla
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
3-表齐墩果酸	CFN92068	25499-90-5	1mg	QQ客服：3257982914
3-表齐墩果酸	CFN92068	25499-90-5	5mg	QQ客服：3257982914
3-表齐墩果酸	CFN92068	25499-90-5	10mg	QQ客服：3257982914
3-表齐墩果酸	CFN92068	25499-90-5	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Monash University Sunway Campus (Malaysia)

Universidade Católica Portuguesa (Portugal)

China Medical University (Taiwan)

Research Unit Molecular Epigenetics (MEG) (Germany)

CSIRO - Agriculture Flagship (Australia)

Universidad Veracuzana (Mexico)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

Universidade do Porto (Portugal)

Imperial College London (United Kingdom)

Medical University of South Carolina (USA)

Northeast Normal University Changchun (China)

Hamdard University (India)

Cornell University (USA)

Kazusa DNA Research Institute (Japan)

More...

Description:

3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.

Targets:

AChR

In vitro:

J Pharm Biomed Anal. 2000 Dec;24(1):133-45.

The uterotonic activity of compounds isolated from the supercritical fluid extract of Ekebergia capensis.[Pubmed: 11108547]

The wood of Ekebergia capensis Sparrm. is used by the local Zulu community in KwaZulu-Natal Province, South Africa to facilitate childbirth.
METHODS AND RESULTS:
In this investigation, the uterotonic properties of extracts from this tree were evaluated using both pregnant and non-pregnant guinea pig uterine smooth muscle in vitro. The extracts were prepared using water modified supercritical carbon dioxide at 400 atm and 80 degrees C. As samples of these extracts displayed positive results when screened for uterotonic activity, gravity column chromatography followed by NMR spectroscopy was performed in an attempt to isolate and elucidate the structures of the compounds that were present in the extract. The extract yielded five known compounds of which only two, viz. oleanonic acid and 3-Epioleanolic acid, displayed uterotonic activity. Receptor binding assays were subsequently performed with 3-Epioleanolic acid to ascertain its mode of action. Bradykinin (30 ng/100 microl) and acetylcholine (1 microg/100 microl) were used as the B2 and cholinergic receptor agonists respectively with icatibant (HOE 140) (30 ng/100 microl) and atropine (60 micro/100 microl) as their corresponding antagonists. 3-Epioleanolic acid was observed to mediate its effect through the cholinergic receptor.
CONCLUSIONS:
The results of this study show that two compounds from the extract of this tree possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.

In vivo:

Phytother Res. 2000 Sep;14(6):463-5.

Antiinflammatory activity and chemical composition of extracts of Verbena officinalis.[Pubmed: 10960904]

METHODS AND RESULTS:
In an attempt to locate the biologically active fraction(s) of the plant Verbena officinalis Linn. (Verbenaceae), a preliminary screening of successive petroleum ether, chloroform and methanol extracts of aerial parts for antiinflammatory activity using carrageenan paw oedema model was carried out. All three extracts were found to exhibit antiinflammatory activity with the chloroform extract being the most active. Chemical investigations of petroleum ether and chloroform extracts led to the isolation of beta-sitosterol, ursolic acid, oleanolic acid, 3-epiursolic acid, 3-Epioleanolic acid, and minor triterpenoids of derivatives of ursolic acid and oleanolic acids.
CONCLUSIONS:
Chromatographic purification of the methanol extract yielded two iridoid glucosides, verbenalin and hastatoside, a phenylpropanoid glycoside, verbascoside and beta-sitosterol-D-glucoside.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid	CFN96050	97534-10-6	C₃₉H₅₄O₆ = 618.9	5mg	QQ客服：2159513211
3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid; 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid	CFN95710	469895-08-7	C₃₂H₅₀O₅ = 514.8	5mg	QQ客服：2159513211
3-氧代-12-烯-28-齐墩果酸; 3-oxo-Olean-12-en-28-oic acid	CFN92194	17990-42-0	C₃₀H₄₆O₃ = 454.7	20mg	QQ客服：3257982914
3-Keto-齐墩果酸-28-甲酯; 3-Oxo-olean-12-en-28-oic acid methyl ester	CFN91814	1721-58-0	C₃₁H₄₈O₃ = 468.7	5mg	QQ客服：1413575084
Virgatic acid; Virgatic acid	CFN96451	14356-51-5	C₃₀H₄₆O₄ = 470.70	5mg	QQ客服：1413575084
刺囊酸; Echinocystic acid	CFN98812	510-30-5	C₃₀H₄₈O₄ = 472.7	20mg	QQ客服：1457312923
3alpha-木通萜酸; 3alpha-Akebonoic acid	CFN99067	104777-61-9	C₂₉H₄₄O₃ = 440.7	5mg	QQ客服：1413575084
Sebiferenic acid; Sebiferenic acid	CFN97523	94390-09-7	C₃₀H₄₈O₄ = 472.7	5mg	QQ客服：1413575084
3,4-开环-齐墩果-12-烯-4-醇-3,28-二酸; 3,4-seco-Olean-12-en-4-ol-3,28-dioic acid	CFN96849	182249-69-0	C₃₀H₄₈O₅ = 488.70	5mg	QQ客服：1413575084
3-氧代-24-去甲齐墩果-12-烯-28-酸 ; Hedragonic acid	CFN96602	466-02-4	C₂₉H₄₄O₃ = 440.66	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	43.7924 mL	54.7405 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	8.7585 mL	10.9481 mL
10 mM	0.219 mL	1.0948 mL	2.1896 mL	4.3792 mL	5.4741 mL
50 mM	0.0438 mL	0.219 mL	0.4379 mL	0.8758 mL	1.0948 mL
100 mM	0.0219 mL	0.1095 mL	0.219 mL	0.4379 mL	0.5474 mL

3-表齐墩果酸

3-Epioleanolic acid

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