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  • 3-表科罗索酸

    3-Epicorosolic acid

    3-表科罗索酸
    产品编号 CFN98851
    CAS编号 52213-27-1
    分子式 = 分子量 C30H48O4 = 472.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The dried fruit of Ziziphus jujuba.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-表科罗索酸 CFN98851 52213-27-1 1mg QQ客服:1413575084
    3-表科罗索酸 CFN98851 52213-27-1 5mg QQ客服:1413575084
    3-表科罗索酸 CFN98851 52213-27-1 10mg QQ客服:1413575084
    3-表科罗索酸 CFN98851 52213-27-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Northeast Normal University Changchun (China)
  • Gyeongsang National University (Korea)
  • University of Beira Interior (Portugal)
  • Charles Sturt University (Denmark)
  • Kitasato University (Japan)
  • University of Helsinki (Finland)
  • University of Dicle (Turkey)
  • Universitas Airlangga (Indonesia)
  • University of Auckland (New Zealand)
  • Wroclaw Medical University (Poland)
  • Charles University in Prague (Czech Republic)
  • Texas A&M University (USA)
  • University Medical Center Mainz (Germany)
  • Universidad de La Salle (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • ACS Omega2020, 5,33,20825-20830
  • Food Analytical Methods2017, 10:3225-3234
  • Foods.2021, 10(6):1378.
  • Front Pharmacol.2020, 11:683.
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Planta Med.2019, 85(9-10):766-773
  • Sci Rep. 2017, 12953(7)
  • J Insect Sci.2020, 20(5):18.
  • SBRAS2016, 12
  • Planta Med.2023, 2192-2281
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Biomed Pharmacother.2022, 145:112474.
  • China Pharmacy2015, 26(27)
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • Environ Toxicol.2019, 34(12):1354-1362
  • Journal of Functional Foods2022, 99: 105331.
  • Cells.2022, 11(8), 1311.
  • J. Food Composition and Analysis2022, 114:104731
  • Molecules.2018, 23(12):E3103
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Front Immunol.2018, 9:2091
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • Toxicol In Vitro.2019, 59:161-178
  • ...
  • 生物活性
    Description: 3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 30.18 and 4.08 μg/ml respectively.
    Targets: Immunology & Inflammation related
    In vivo:
    Biosci Biotechnol Biochem. 2004 Jan;68(1):85-90.
    Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.[Pubmed: 14745168]

    METHODS AND RESULTS:
    Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4-9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice.
    CONCLUSIONS:
    All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09-0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1-3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91-93% inhibition at 1x10(3) mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.
    Bioorg Med Chem Lett. 2015 Oct 1;25(19):4342-6.
    Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties.[Pubmed: 26259803]

    METHODS AND RESULTS:
    The scalable syntheses of four oxygenated triterpenes have been implemented to access substantial quantities of maslinic acid, 3-epimaslinic acid, corosolic acid, and 3-Epicorosolic acid. Semi-syntheses proceed starting from the natural products oleanolic acid and ursolic acid. Proceeding over five steps, each of the four compounds can be synthesized on the gram scale. Divergent diastereoselective reductions of α-hydroxy ketones provided access to the four targeted diol containing compounds from two precursors of the oleanane or ursane lineage. These compounds were subsequently evaluated for their ability to inhibit inflammatory gene expression in a mouse model of chemically induced skin inflammation.
    CONCLUSIONS:
    All compounds possessed the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, however, three of the compounds, corosolic acid, 3-Epicorosolic acid and maslinic acid were more effective than the others. The availability of gram quantities will allow further testing of these compounds for potential anti-inflammatory activities as well as cancer chemopreventive activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1155 mL 10.5775 mL 21.1551 mL 42.3101 mL 52.8877 mL
    5 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
    10 mM 0.2116 mL 1.0578 mL 2.1155 mL 4.231 mL 5.2888 mL
    50 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
    100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4231 mL 0.5289 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    高加蓝花楹三萜酸; Jacoumaric acid CFN92274 63303-42-4 C39H54O6 = 618.9 5mg QQ客服:2159513211
    3-表熊果酸; 3-Epiursolic acid CFN92196 989-30-0 C30H48O3 = 456.7 20mg QQ客服:215959384
    熊果酸; Ursolic acid CFN97259 77-52-1 C30H48O3 = 456.7 20mg QQ客服:1457312923
    熊果酸乙酸酯; Acetylursolic acid CFN97219 7372-30-7 C32H50O4 = 498.8 10mg QQ客服:3257982914
    3-氧代-12-烯-28-乌苏酸; Ursonic acid CFN97078 6246-46-4 C30H46O3 = 454.7 20mg QQ客服:1457312923
    Randialic acid B; Randialic acid B CFN91138 14021-14-8 C30H46O3 = 454.7 5mg QQ客服:2159513211
    地榆皂苷元; Sanguisorbigenin CFN91139 6812-98-2 C30H46O3 = 454.7 5mg QQ客服:1457312923
    Obtusilin; Obtusilin CFN90556 105870-59-5 C30H46O4 = 470.69 5mg QQ客服:215959384
    全草含茜草萜酸; Rubifolic acid CFN97281 80489-65-2 C30H48O4 = 472.7 5mg QQ客服:1413575084
    3beta-羟基乌苏-30-对羟基肉桂酰基-12-烯-28-酸; Zamanic acid CFN98292 260393-05-3 C39H54O6 = 618.9 5mg QQ客服:215959384

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