| In vitro: |
| Journal of Applied Biological Chemistry, 2012,55(3):169-172. | | Antibacterial Activity of Triterpenoids from Clerodendron trichotomum.[Reference: WebLink] | The aim of this research was to investigate the antibacterial activity of Clerodendron trichotomum.
METHODS AND RESULTS:
Antibacterial activities of the n-hexane, methylene chloride (MC), ethyl acetate, and n-butanol fractions from C. trichotomum were tested against Staphylococcus aureus, Escherichia coli, and Helicobacter pylori. The n-hexane and MC fractions showed antibacterial activity against H. pylori at a concentration of 1.7 mg/mL and showed inhibition zones of 10 and 11 mm in disc assay, respectively. Further testing of 22-Dehydroclerosterol and β-amyrin (each 3.4 mg/mL) from the MC fraction of C. trichotomum revealed moderate antibacterial effects against E. coli, S. aureus, and H. pylori. In particular, β-amyrin showed clear zones of 12 and 13 mm against E. coli and H. pylori, respectively, suggesting its potential as an antibacterial agent.
CONCLUSIONS:
The active compounds from C. trichotomum might provide a promising therapeutic agent against infections by E. coli, S. aureus, and H. pylori. |
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