2-甲氧基-6-乙酰基-7-甲基胡桃酮

2-Methoxystypandrone

	产品编号	CFN97412
	CAS编号	85122-21-0
	分子式 = 分子量	C₁₄H₁₂O₅ = 260.2
	产品纯度	>=98%
	物理属性	Red powder
	化合物类型	Quinones
	植物来源	The roots of Polygonum cuspidatum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	1mg	QQ客服：1457312923
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	5mg	QQ客服：1457312923
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	10mg	QQ客服：1457312923
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	20mg	QQ客服：1457312923

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Agricultural Research Organization (ARO) (Israel)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Mendel University in Brno (Czech Republic)

University of Melbourne (Australia)

Copenhagen University (Denmark)

Funda??o Universitária de Desenvolvimento (Brazil)

Instituto de Investigaciones Agropecuarias (Chile)

Nicolaus Copernicus Uniwersity (Poland)

Utah State University (USA)

University of Helsinki (Finland)

Heidelberg University (Germany)

Institute of Chinese Materia Medica (China)

Sapienza University of Rome (Italy)

Chinese University of Hong Kong (China)

More...

Description:

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

Targets:

JAK | IkB | NF-kB | TNF-α | STAT | NOS | COX | p65 | GSK-3 | Bcl-2/Bax | Wnt/β-catenin | MMP(e.g.TIMP) | IKK

In vivo:

Biochem Pharmacol. 2014 Feb 1;87(3):502-14.

2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke.[Pubmed: 24342702 ]

2-Methoxystypandrone (2-MS), a naphthoquinone, has been shown to display an immunomodulatory effect in a cellular model.
METHODS AND RESULTS:
To explore whether 2-Methoxystypandrone could protect mice against cerebral ischemic/reperfusion (I/R)-induced brain injury, we evaluated 2-Methoxystypandrone's protective effects on an acute ischemic stroke by inducing a middle cerebral artery occlusion/reperfusion (MCAO) injury in murine model. Treatment of mice that have undergone I/R injury with 2-Methoxystypandrone (10-100 μg/kg, i.v.) at 2 h after MCAO enhanced survival rate and ameliorated neurological deficits, brain infarction, neural dysfunction and massive oxidative stress, due to an enormous production of free radicals and breakdown of blood-brain barrier (BBB) by I/R injury; this primarily occurred with extensive infiltration of CD11b-positive inflammatory cells and upexpression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 and p65 nuclear factor-kappa B (NF-κB). All of these pathological changes were diminished by 2-Methoxystypandrone; 2-Methoxystypandrone also intensively limited cortical infarction and promoted upexpression of neurodevelopmental genes near peri-infarct cortex and endogenous neurogenesis near subgranular zone of hippocampal dentate gyrus and the subventricular zone, most possibly by inactivation of GSK3β which in turn upregulating β-catenin, Bcl-2 adam11 and adamts20.
CONCLUSIONS:
We conclude that 2-Methoxystypandrone blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity; 2-Methoxystypandrone also concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2,6-二甲氧基-1-乙酰甲基氢醌; 2,6-Dimethoxy-1-acetonylquinol	CFN98207	2215-96-5	C₁₁H₁₄O₅ = 226.2	5mg	QQ客服：2159513211
(1-羟基-4-氧代-2,5-环己二烯-1-基)乙酸乙酯; Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate	CFN97022	60263-06-1	C₁₀H₁₂O₄ = 196.2	5mg	QQ客服：215959384
叶点霉素; Phyllostine	CFN97901	27270-89-9	C₇H₆O₄ = 154.1	5mg	QQ客服：215959384
(4R)-3,4-二氢-4,8-二羟基-1(2H)-萘酮; Regiolone	CFN96886	137494-04-3	C₁₀H₁₀O₃ = 178.18	5mg	QQ客服：1413575084
2-羟基-1,4萘醌; 2-Hydroxy-1,4-naphoquinone	CFN91715	83-72-7	C₁₀H₆O₃ = 174.15	20mg	QQ客服：2159513211
胡桃酮，5-羟基对萘醌; Juglone	CFN90497	481-39-0	C₁₀H₆O₃ = 174.16	20mg	QQ客服：2159513211
2-甲氧基-1,4-萘并醌; 2-Methoxy-1,4-naphthoquinone	CFN95269	2348-82-5	C₁₁H₈O₃ = 188.2	20mg	QQ客服：1413575084
兰雪醌; Plumbagin	CFN90444	481-42-5	C₁₁H₈O₃ = 188.17	20mg	QQ客服：1457312923
梅笠草素; Chimaphilin	CFN95676	482-70-2	C₁₂H₁₀O₂ = 186.2	20mg	QQ客服：3257982914
7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione; 7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione	CFN95672	145626-36-4	C₁₂H₁₀O₃ = 202.2	10mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8432 mL	19.216 mL	38.432 mL	76.864 mL	96.0799 mL
5 mM	0.7686 mL	3.8432 mL	7.6864 mL	15.3728 mL	19.216 mL
10 mM	0.3843 mL	1.9216 mL	3.8432 mL	7.6864 mL	9.608 mL
50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.5373 mL	1.9216 mL
100 mM	0.0384 mL	0.1922 mL	0.3843 mL	0.7686 mL	0.9608 mL

2-甲氧基-6-乙酰基-7-甲基胡桃酮

2-Methoxystypandrone

信息支持

联系方式