2-甲氧基-6-乙酰基-7-甲基胡桃酮

2-Methoxystypandrone

	产品编号	CFN97412
	CAS编号	85122-21-0
	分子式 = 分子量	C₁₄H₁₂O₅ = 260.2
	产品纯度	>=98%
	物理属性	Red powder
	化合物类型	Quinones
	植物来源	The roots of Polygonum cuspidatum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	1mg	QQ客服：1457312923
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	5mg	QQ客服：1457312923
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	10mg	QQ客服：1457312923
2-甲氧基-6-乙酰基-7-甲基胡桃酮	CFN97412	85122-21-0	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

Targets:

JAK | IkB | NF-kB | TNF-α | STAT | NOS | COX | p65 | GSK-3 | Bcl-2/Bax | Wnt/β-catenin | MMP(e.g.TIMP) | IKK

In vivo:

Biochem Pharmacol. 2014 Feb 1;87(3):502-14.

2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke.[Pubmed: 24342702 ]

2-Methoxystypandrone (2-MS), a naphthoquinone, has been shown to display an immunomodulatory effect in a cellular model.
METHODS AND RESULTS:
To explore whether 2-Methoxystypandrone could protect mice against cerebral ischemic/reperfusion (I/R)-induced brain injury, we evaluated 2-Methoxystypandrone's protective effects on an acute ischemic stroke by inducing a middle cerebral artery occlusion/reperfusion (MCAO) injury in murine model. Treatment of mice that have undergone I/R injury with 2-Methoxystypandrone (10-100 μg/kg, i.v.) at 2 h after MCAO enhanced survival rate and ameliorated neurological deficits, brain infarction, neural dysfunction and massive oxidative stress, due to an enormous production of free radicals and breakdown of blood-brain barrier (BBB) by I/R injury; this primarily occurred with extensive infiltration of CD11b-positive inflammatory cells and upexpression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 and p65 nuclear factor-kappa B (NF-κB). All of these pathological changes were diminished by 2-Methoxystypandrone; 2-Methoxystypandrone also intensively limited cortical infarction and promoted upexpression of neurodevelopmental genes near peri-infarct cortex and endogenous neurogenesis near subgranular zone of hippocampal dentate gyrus and the subventricular zone, most possibly by inactivation of GSK3β which in turn upregulating β-catenin, Bcl-2 adam11 and adamts20.
CONCLUSIONS:
We conclude that 2-Methoxystypandrone blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity; 2-Methoxystypandrone also concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Prerubialatin; Prerubialatin	CFN96585	1667718-89-9	C₂₇H₂₀O₇ = 456.45	5mg	QQ客服：2159513211
2,6-二甲氧基-1-乙酰甲基氢醌; 2,6-Dimethoxy-1-acetonylquinol	CFN98207	2215-96-5	C₁₁H₁₄O₅ = 226.2	5mg	QQ客服：3257982914
(1-羟基-4-氧代-2,5-环己二烯-1-基)乙酸乙酯; Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate	CFN97022	60263-06-1	C₁₀H₁₂O₄ = 196.2	5mg	QQ客服：215959384
叶点霉素; Phyllostine	CFN97901	27270-89-9	C₇H₆O₄ = 154.1	5mg	QQ客服：2056216494
(4R)-3,4-二氢-4,8-二羟基-1(2H)-萘酮; Regiolone	CFN96886	137494-04-3	C₁₀H₁₀O₃ = 178.18	5mg	QQ客服：1457312923
2-羟基-1,4萘醌; 2-Hydroxy-1,4-naphoquinone	CFN91715	83-72-7	C₁₀H₆O₃ = 174.15	20mg	QQ客服：215959384
胡桃酮，5-羟基对萘醌; Juglone	CFN90497	481-39-0	C₁₀H₆O₃ = 174.16	20mg	QQ客服：215959384
2-甲氧基-1,4-萘并醌; 2-Methoxy-1,4-naphthoquinone	CFN95269	2348-82-5	C₁₁H₈O₃ = 188.2	20mg	QQ客服：2056216494
兰雪醌; Plumbagin	CFN90444	481-42-5	C₁₁H₈O₃ = 188.17	20mg	QQ客服：215959384
梅笠草素; Chimaphilin	CFN95676	482-70-2	C₁₂H₁₀O₂ = 186.2	20mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8432 mL	19.216 mL	38.432 mL	76.864 mL	96.0799 mL
5 mM	0.7686 mL	3.8432 mL	7.6864 mL	15.3728 mL	19.216 mL
10 mM	0.3843 mL	1.9216 mL	3.8432 mL	7.6864 mL	9.608 mL
50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.5373 mL	1.9216 mL
100 mM	0.0384 mL	0.1922 mL	0.3843 mL	0.7686 mL	0.9608 mL

2-甲氧基-6-乙酰基-7-甲基胡桃酮

2-Methoxystypandrone

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