
2-甲氧基-6-乙酰基-7-甲基胡桃酮
2-Methoxystypandrone
|
产品编号 |
CFN97412 |
CAS编号 |
85122-21-0 |
分子式 = 分子量 |
C14H12O5 = 260.2 |
产品纯度 |
>=98% |
物理属性 |
Red powder |
化合物类型 |
Quinones |
植物来源 |
The roots of Polygonum cuspidatum |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
2-甲氧基-6-乙酰基-7-甲基胡桃酮 |
CFN97412 |
85122-21-0 |
1mg |
QQ客服:3257982914 |
2-甲氧基-6-乙酰基-7-甲基胡桃酮 |
CFN97412 |
85122-21-0 |
5mg |
QQ客服:3257982914 |
2-甲氧基-6-乙酰基-7-甲基胡桃酮 |
CFN97412 |
85122-21-0 |
10mg |
QQ客服:3257982914 |
2-甲氧基-6-乙酰基-7-甲基胡桃酮 |
CFN97412 |
85122-21-0 |
20mg |
QQ客服:3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
Universidade Federal de Pernambuco (UFPE) (Brazil)
The Institute of Cancer Research (United Kingdom)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
Center for protein Engineering (CIP) (Belgium)
China Medical University (Taiwan)
Macau University of Science and Technology (China)
Shanghai Institute of Organic Chemistry (China)
Institute of Chinese Materia Medica (China)
University of Helsinki (Finland)
Regional Crop Research Institute (Korea)
University of Malaya (Malaysia)
Melbourne University (Australia)
Institute of Pathophysiology Medical University of Vienna (Austria)
Max Rubner-Institut (MRI) (Germany)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption. |
Targets: |
JAK | IkB | NF-kB | TNF-α | STAT | NOS | COX | p65 | GSK-3 | Bcl-2/Bax | Wnt/β-catenin | MMP(e.g.TIMP) | IKK |
In vivo: |
Biochem Pharmacol. 2014 Feb 1;87(3):502-14. | 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke.[Pubmed: 24342702 ] | 2-Methoxystypandrone (2-MS), a naphthoquinone, has been shown to display an immunomodulatory effect in a cellular model.
METHODS AND RESULTS:
To explore whether 2-Methoxystypandrone could protect mice against cerebral ischemic/reperfusion (I/R)-induced brain injury, we evaluated 2-Methoxystypandrone's protective effects on an acute ischemic stroke by inducing a middle cerebral artery occlusion/reperfusion (MCAO) injury in murine model. Treatment of mice that have undergone I/R injury with 2-Methoxystypandrone (10-100 μg/kg, i.v.) at 2 h after MCAO enhanced survival rate and ameliorated neurological deficits, brain infarction, neural dysfunction and massive oxidative stress, due to an enormous production of free radicals and breakdown of blood-brain barrier (BBB) by I/R injury; this primarily occurred with extensive infiltration of CD11b-positive inflammatory cells and upexpression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 and p65 nuclear factor-kappa B (NF-κB). All of these pathological changes were diminished by 2-Methoxystypandrone; 2-Methoxystypandrone also intensively limited cortical infarction and promoted upexpression of neurodevelopmental genes near peri-infarct cortex and endogenous neurogenesis near subgranular zone of hippocampal dentate gyrus and the subventricular zone, most possibly by inactivation of GSK3β which in turn upregulating β-catenin, Bcl-2 adam11 and adamts20.
CONCLUSIONS:
We conclude that 2-Methoxystypandrone blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity; 2-Methoxystypandrone also concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
3.8432 mL |
19.216 mL |
38.432 mL |
76.864 mL |
96.0799 mL |
5 mM |
0.7686 mL |
3.8432 mL |
7.6864 mL |
15.3728 mL |
19.216 mL |
10 mM |
0.3843 mL |
1.9216 mL |
3.8432 mL |
7.6864 mL |
9.608 mL |
50 mM |
0.0769 mL |
0.3843 mL |
0.7686 mL |
1.5373 mL |
1.9216 mL |
100 mM |
0.0384 mL |
0.1922 mL |
0.3843 mL |
0.7686 mL |
0.9608 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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