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  • 2-去氧-4-表-天人菊灵

    2-Desoxy-4-epi-pulchellin

    2-去氧-4-表-天人菊灵
    产品编号 CFN99345
    CAS编号 122872-03-1
    分子式 = 分子量 C15H22O3 = 250.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Carpesium abrotanoides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2-去氧-4-表-天人菊灵 CFN99345 122872-03-1 10mg QQ客服:1457312923
    2-去氧-4-表-天人菊灵 CFN99345 122872-03-1 20mg QQ客服:1457312923
    2-去氧-4-表-天人菊灵 CFN99345 122872-03-1 50mg QQ客服:1457312923
    2-去氧-4-表-天人菊灵 CFN99345 122872-03-1 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:652860.
  • Antioxidants2022, 11(2),234.
  • J of Food Quality2020, 8851285.
  • Foods.2021, 10(6):1378.
  • Sci Rep. 2017, 8207(7)
  • Cell Physiol Biochem.2019, 52(6):1255-1266
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  • Mol Neurobiol.2021, 58(8):3665-3676.
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  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • University of Limpopo2016, 1-237
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Korean Journal of Pharmacognosy2014, 113-120
  • Sci Rep.2017, 7(1):3249
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Process Biochemistry2019, 85:106-115
  • Acta Agriculturae Scandinavica2015, 381-383
  • Plant Archives2020, 2(1),2929-2934
  • ...
  • 生物活性
    Description: 2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows significant antiviral (H1N1 and H3N2) activities, it also displays significant antimycobacterial activity (IC50=7.6 uM).
    Targets: Antifection
    In vitro:
    Bioorg Med Chem Lett. 2015 Oct 1;25(19):4082-4.
    Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.[Pubmed: 26316467 ]

    METHODS AND RESULTS:
    A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11(13)-dehydroivaxillin (3), and 2-Desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis, and single crystal X-ray diffraction analysis. Compound 1 possessed a dimeric sesquiterpene core featured with a cyclopentane ring connecting two sesquiterpene lactone units rarely discovered in nature.
    CONCLUSIONS:
    Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 μM, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 μM, respectively).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9952 mL 19.976 mL 39.9521 mL 79.9041 mL 99.8801 mL
    5 mM 0.799 mL 3.9952 mL 7.9904 mL 15.9808 mL 19.976 mL
    10 mM 0.3995 mL 1.9976 mL 3.9952 mL 7.9904 mL 9.988 mL
    50 mM 0.0799 mL 0.3995 mL 0.799 mL 1.5981 mL 1.9976 mL
    100 mM 0.04 mL 0.1998 mL 0.3995 mL 0.799 mL 0.9988 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on; 5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on CFN95522 114579-31-6 C15H22O3 = 250.3 5mg QQ客服:1413575084
    2-去氧-4-表-天人菊灵; 2-Desoxy-4-epi-pulchellin CFN99345 122872-03-1 C15H22O3 = 250.3 20mg QQ客服:215959384
    Carabrolactone B; Carabrolactone B CFN99287 1187925-31-0 C15H22O4 = 266.3 5mg QQ客服:3257982914
    旋覆花内酯; Britannin CFN90220 33627-28-0 C19H26O7 = 366.41 20mg QQ客服:1413575084
    麦角内酯; Ergolide CFN91552 54999-07-4 C17H22O5 = 306.4 10mg QQ客服:1413575084
    锦鸡菊素; Helenalin CFN91899 6754-13-8 C15H18O4 = 262.30 5mg QQ客服:2056216494
    山金草内酯C; Arnicolide C CFN91996 34532-67-7 C19H26O5 = 334.41 5mg QQ客服:3257982914
    山金草内酯D; Arnicolide D CFN91999 34532-68-8 C19H24O5 = 332.39 10mg QQ客服:2159513211
    小堆心菊素C; Microhelenin C CFN91997 63569-07-3 C20H26O5 = 346.42 5mg QQ客服:1457312923
    短叶老鹤草素A; Brevilin A CFN99694 16503-32-5 C20H26O5 = 346.4 20mg QQ客服:1413575084

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