Info: Read More
    		•
  • 中药标准品生产商，产品定制服务
    		•
  • 首页
  • 天然产物
  • 产品文献
  • 最新产品
  • 订购流程
  • 公司新闻
  • 公司简介
  • 联系我们
  • 首页
  • /
  • 天然产物（标准品）
  • /
  • 2'-3'-dehydrosalannol

    • 2'-3'-dehydrosalannol

    2',3'-Dehydrosalannol

    2'-3'-dehydrosalannol
    		产品编号 CFN97589
    CAS编号 97411-50-2
    分子式 = 分子量 C32H42O8 = 554.68
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Azadirachta indica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2'-3'-dehydrosalannol CFN97589 97411-50-2 1mg QQ客服：1413575084
    2'-3'-dehydrosalannol CFN97589 97411-50-2 5mg QQ客服：1413575084
    2'-3'-dehydrosalannol CFN97589 97411-50-2 10mg QQ客服：1413575084
    2'-3'-dehydrosalannol CFN97589 97411-50-2 20mg QQ客服：1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

    2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话：
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到：027-84254680

    • 提供订购信息
  • 为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号（CAS No.或产品名称）
  • 2. 发货地址
  • 3. 联系方法 (联系人，电话）
  • 4. 开票抬头 (如果需要发票的客户）
  • 5. 发票地址（发货地址与发票地址不同）
    • 发货时间
    1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Sapienza University of Rome (Italy)
  • University of Hertfordshire (United Kingdom)
  • Srinakharinwirot University (Thailand)
  • Mahidol University (Thailand)
  • Weizmann Institute of Science (Israel)
  • Seoul National University of Science and Technology (Korea)
  • St. Jude Children Research Hospital (USA)
  • University of Pretoria (South Africa)
  • University of Minnesota (USA)
  • Monash University (Australia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of British Columbia (Canada)
  • Florida International University (USA)
  • Universita' Degli Studi Di Cagliari (Italy)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Pharmaceutics.2020, 12(9):882.
  • J Nat Prod.2023, 86(2):264-275.
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • Pathogens.2018, 7(3):E62
  • Chem Biol Interact.2023, 378:110487.
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • FASEB J.2019, 33(2):2026-2036
  • Lab Chip.2018, 18(6):971-978
  • Process Biochemistry2019, 85:106-115
  • Free Radic Biol Med.2021, 166:104-115.
  • Food Research2022, 6(6): 30-38.
  • J Plant Biotechnol.2023, 50:070-075.
  • Mol Pharm.2018, 15(8):3285-3296
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Anticancer Res.2018, 38(4):2127-2135
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Biomedicines.2020, 8(11):486.
  • Metabolites2023, 13(1), 3.
  • VNU J of Science: Med.&Pharm. Sci.2023, 39(1):20-29.
  • ...
    • 生物活性
    Description: 2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits cathepsin-mediated pro-survival signaling which resulted in growth arrest of TNBC cells.
    Targets: Bcl-2/Bax | Caspase | Akt
    In vitro:
    Anticancer Res. 2012 Jul;32(7):2801-6.
    The anticancer effect of 2'-3'-dehydrosalannol on triple-negative breast cancer cells.[Pubmed: 22753740]
    Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast tumors and these breast tumors are usually aggressive and highly metastatic. Unfortunately, treatment options for TNBCs are limited; we have identified a novel molecule,2',3'-Dehydrosalannol (DHS) and in this study we investigated the anticancer effect of DHS against TNBC cells.
    METHODS AND RESULTS:
    TNBC (MDA-MB 231; MDA-MB 468) cells were treated with DHS and its effect on cell viability, apoptosis and molecular mechanisms were analyzed. DHS inhibited growth and induced apoptosis in TNBC cell lines. Molecular analysis suggested that DHS inhibited cathepsin-mediated pro-survival signaling [pAKT: phosphorylated protein kinase B; BCL-2: B-cell lymphoma 2 and cyclin D1] and induced pro-apoptotic markers such as BAX [BCL-2-associated X protein] and cleaved caspase-3.
    CONCLUSIONS:
    Our results demonstrate that DHS inhibits cathepsin-mediated pro-survival signaling which resulted in growth arrest of TNBC cells. These findings suggest that DHS may be a promising agent for the prevention and treatment of TNBC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8028 mL 9.0142 mL 18.0284 mL 36.0568 mL 45.071 mL
    5 mM 0.3606 mL 1.8028 mL 3.6057 mL 7.2114 mL 9.0142 mL
    10 mM 0.1803 mL 0.9014 mL 1.8028 mL 3.6057 mL 4.5071 mL
    50 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.7211 mL 0.9014 mL
    100 mM 0.018 mL 0.0901 mL 0.1803 mL 0.3606 mL 0.4507 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    印楝沙兰林; Salannin CFN91920 992-20-1 C34H44O9 = 596.71 5mg QQ客服：2056216494
    Ohchinin; Ohchinin CFN97704 67023-80-7 C36H42O8 = 602.73 5mg QQ客服：3257982914
    Ohchinin acetate; Ohchinin acetate CFN97143 67023-81-8 C38H44O9 = 644.8 5mg QQ客服：215959384
    1-Deacetylnimbolinin B; 1-Deacetylnimbolinin B CFN97244 76689-98-0 C33H44O9 = 584.7 5mg QQ客服：3257982914
    28-去氧代印苦楝内酯; 28-Deoxonimbolide CFN97835 126005-94-5 C27H32O6 = 452.55 5mg QQ客服：215959384
    印苦楝内酯; Nimbolide CFN91919 25990-37-8 C27H30O7 = 466.52 10mg QQ客服：2159513211
    2,3-二氢-3alpha-甲氧基印苦楝内酯; 2,3-Dihydro-3alpha-methoxynimbolide CFN96791 1607828-35-2 C28H34O8 = 498.57 5mg QQ客服：3257982914
    脱乙酰基印楝素; Deacetylnimbin CFN97797 18609-16-0 C28H34O8 = 498.57 5mg QQ客服：2159513211
    印楝素; Nimbin CFN97722 5945-86-8 C30H36O9 = 540.61 5mg QQ客服：215959384
    2'-3'-dehydrosalannol; 2',3'-Dehydrosalannol CFN97589 97411-50-2 C32H42O8 = 554.68 5mg QQ客服：3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

    联系方式


    电机：027-84237783
    传真：027-84254680
    在线QQ: 1413575084
    E-Mail：manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。