14-苯甲酰基尼奥林
14-Benzoylneoline
|
|
产品编号 |
CFN96225 |
| CAS编号 |
99633-05-3 |
| 分子式 = 分子量 |
C31H43NO7 = 541.7 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Alkaloids |
| 植物来源 |
The roots of Aconitum carmichaeli |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 14-苯甲酰基尼奥林 |
CFN96225 |
99633-05-3 |
1mg |
QQ客服：1413575084 |
| 14-苯甲酰基尼奥林 |
CFN96225 |
99633-05-3 |
5mg |
QQ客服：1413575084 |
| 14-苯甲酰基尼奥林 |
CFN96225 |
99633-05-3 |
10mg |
QQ客服：1413575084 |
| 14-苯甲酰基尼奥林 |
CFN96225 |
99633-05-3 |
20mg |
QQ客服：1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
University of Hull (United Kingdom)
University of Zurich (Switzerland)
Uniwersytet Medyczny w ?odzi (Poland)
University of Bordeaux (France)
Deutsches Krebsforschungszentrum (Germany)
Sanford Burnham Prebys Medical Discovery Institute (USA)
Korea Intitute of Science and Technology (KIST) (Korea)
University of Indonesia (Indonesia)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Technical University of Denmark (Denmark)
FORTH-IMBB (Greece)
Univerzita Karlova v Praze (Czech Republic)
Monash University Malaysia (Malaysia)
University of Ioannina (Greece)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
14-Benzoylneoline is a natural product from Aconitum carmichaeli. |
| In vitro: |
| Anal Chem. 2014 May 20;86(10):4748-57. | | Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli.[Pubmed: 24731167 ] | Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on specific diseases from complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no pathological tissue-derived CMC models that have ever been developed, as well as no visualized affinity comparison of potential active components between normal and pathological CMC columns.
METHODS AND RESULTS:
In this study, a novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional (2D) chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, as well as rapid screening of the specific therapeutic agents that counteract doxorubicin (DOX)-induced heart failure from Acontium carmichaeli (Fuzi). In total, 16 potential active alkaloid components with similar structures in Fuzi were retained on both normal and failing myocardium CMC models. Most of them had obvious decreases of affinities on failing myocardium CMC compared with normal CMC model except for four components, talatizamine (TALA), 14-acetyl-TALA, hetisine, and 14-benzoylneoline. One compound TALA with the highest affinity was isolated for further in vitro pharmacodynamic validation and target identification to validate the screen results.
CONCLUSIONS:
Voltage-dependent K(+) channel was confirmed as a binding target of TALA and 14-acetyl-TALA with high affinities. The online high throughput comparative CMC analysis method is suitable for screening specific active components from herbal medicines by increasing the specificity of screened results and can also be applied to other biological chromatography models. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.846 mL |
9.2302 mL |
18.4604 mL |
36.9208 mL |
46.151 mL |
| 5 mM |
0.3692 mL |
1.846 mL |
3.6921 mL |
7.3842 mL |
9.2302 mL |
| 10 mM |
0.1846 mL |
0.923 mL |
1.846 mL |
3.6921 mL |
4.6151 mL |
| 50 mM |
0.0369 mL |
0.1846 mL |
0.3692 mL |
0.7384 mL |
0.923 mL |
| 100 mM |
0.0185 mL |
0.0923 mL |
0.1846 mL |
0.3692 mL |
0.4615 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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