14-苯甲酰基尼奥林

14-Benzoylneoline

	产品编号	CFN96225
	CAS编号	99633-05-3
	分子式 = 分子量	C₃₁H₄₃NO₇ = 541.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Aconitum carmichaeli
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
14-苯甲酰基尼奥林	CFN96225	99633-05-3	1mg	QQ客服：215959384
14-苯甲酰基尼奥林	CFN96225	99633-05-3	5mg	QQ客服：215959384
14-苯甲酰基尼奥林	CFN96225	99633-05-3	10mg	QQ客服：215959384
14-苯甲酰基尼奥林	CFN96225	99633-05-3	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Description:

14-Benzoylneoline is a natural product from Aconitum carmichaeli.

In vitro:

Anal Chem. 2014 May 20;86(10):4748-57.

Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli.[Pubmed: 24731167 ]

Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on specific diseases from complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no pathological tissue-derived CMC models that have ever been developed, as well as no visualized affinity comparison of potential active components between normal and pathological CMC columns.
METHODS AND RESULTS:
In this study, a novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional (2D) chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, as well as rapid screening of the specific therapeutic agents that counteract doxorubicin (DOX)-induced heart failure from Acontium carmichaeli (Fuzi). In total, 16 potential active alkaloid components with similar structures in Fuzi were retained on both normal and failing myocardium CMC models. Most of them had obvious decreases of affinities on failing myocardium CMC compared with normal CMC model except for four components, talatizamine (TALA), 14-acetyl-TALA, hetisine, and 14-benzoylneoline. One compound TALA with the highest affinity was isolated for further in vitro pharmacodynamic validation and target identification to validate the screen results.
CONCLUSIONS:
Voltage-dependent K(+) channel was confirmed as a binding target of TALA and 14-acetyl-TALA with high affinities. The online high throughput comparative CMC analysis method is suitable for screening specific active components from herbal medicines by increasing the specificity of screened results and can also be applied to other biological chromatography models.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Carmichaenine A; Carmichaenine A	CFN89452	2065228-59-1	C₃₁H₄₃NO₇ = 541.67	5mg	QQ客服：2056216494
Carmichaenine E; Carmichaenine E	CFN89453	2065228-63-7	C₃₁H₄₃NO₈ = 557.67	5mg	QQ客服：2159513211
附子灵; Fuziline	CFN90689	80665-72-1	C₂₄H₃₉NO₇ = 453.58	20mg	QQ客服：2159513211
塔拉乌头胺; Talatisamine	CFN98580	20501-56-8	C₂₄H₃₉NO₅ = 421.57	20mg	QQ客服：215959384
10-羟基尼奥林; 10-Hydroxyneoline	CFN96243	132362-42-6	C₂₄H₃₉NO₇ = 453.6	5mg	QQ客服：2159513211
Neolinine; Neolinine	CFN96267	112515-37-4	C₂₃H₃₇NO₆ = 423.6	5mg	QQ客服：3257982914
Carmichaenine B; Carmichaenine B	CFN89456	2065228-60-4	C₂₃H₃₇NO₇ = 439.54	5mg	QQ客服：215959384
硬飞燕草碱; Delsoline	CFN98582	509-18-2	C₂₅H₄₁NO₇ = 467.6	20mg	QQ客服：1413575084
德尔塔林; Deltaline	CFN98581	6836-11-9	C₂₇H₄₁NO₈ = 507.62	20mg	QQ客服：2056216494
查斯曼林,查斯曼宁碱; Chasmanine	CFN98587	5066-78-4	C₂₅H₄₁NO₆ = 451.6	10mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.846 mL	9.2302 mL	18.4604 mL	36.9208 mL	46.151 mL
5 mM	0.3692 mL	1.846 mL	3.6921 mL	7.3842 mL	9.2302 mL
10 mM	0.1846 mL	0.923 mL	1.846 mL	3.6921 mL	4.6151 mL
50 mM	0.0369 mL	0.1846 mL	0.3692 mL	0.7384 mL	0.923 mL
100 mM	0.0185 mL	0.0923 mL	0.1846 mL	0.3692 mL	0.4615 mL