| In vivo: |
| Records of Natural Products, 2007 , 1 (1) :1-16. | | Biological activity of diterpenoids isolated from Anatolian Lamiaceae Plants[Reference: WebLink] |
METHODS AND RESULTS:
Since Salvia species, especially Chinese sage S. milthiorrhiza has been used in the treatment of coronary heart diseases, Prof. Ulubelen group also investigated cardiovascular properties of several Salvia extracts (S. amplexicaulis, S. eriophora and S. syriaca) and their constituents in vivo, on Wistar Albino rats [5, 40-42]. The crude extract of S. eriophora and isolated eleven diterpenoids ferruginol (11), aethiopinone (56), 4,12-dihydroxysapriparaquinone (63), 6,7-didehydroroyleanone (64) and 4,14-dihydroxysaprorthoquinone (65), horminone, acetylhorminone, salvipisone, 12-Hydroxysapriparaquinone, 3,12-dihydroxysapri-paraquinone-1-ene, salvilimbinol, were tested [40] for cardiovascular activity.
CONCLUSIONS:
Among the tested abietanes, compounds 65, 56, 11, 63 and 64 as well as the crude extract showed antihypertensive activity, especially ferruginol, aethiopinone and 4,12- dihydroxysapriparaquinone by significantly reducing arterial blood pressure, and this activity is considered probably due to the vasorelaxation activity [5]. |
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