11-O-没食子酰岩白菜素

11-O-Galloylbergenin

	产品编号	CFN96345
	CAS编号	82958-44-9
	分子式 = 分子量	C₂₁H₂₀O₁₃ = 480.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The aerial parts of Bergenia ligulata.
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产品名称	产品编号	CAS编号	包装	QQ客服
11-O-没食子酰岩白菜素	CFN96345	82958-44-9	1mg	QQ客服：2159513211
11-O-没食子酰岩白菜素	CFN96345	82958-44-9	5mg	QQ客服：2159513211
11-O-没食子酰岩白菜素	CFN96345	82958-44-9	10mg	QQ客服：2159513211
11-O-没食子酰岩白菜素	CFN96345	82958-44-9	20mg	QQ客服：2159513211

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Description:

11-O-Galloylbergenin shows good antioxidant and antiplasmodial activities, it shows significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats, and it exhibits significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.11-O-Galloylbergenin shows significant urease inhibitory potential with IC50 value of 38.6±1.5 uM.

Targets:

Immunology & Inflammation related

In vitro:

Trop Biomed. 2014 Mar;31(1):143-8.

Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata.[Pubmed: 24862054]

In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-Galloylbergenin for the first time.
METHODS AND RESULTS:
Both compounds were isolated from Bergenia ligulata. 11-O-Galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-Galloylbergenin were 7.45±0.2 μg/mL and 5.39±0.28 μg/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay of both compounds were less than 2.5 μM. Interestingly, in the total antioxidant phosphomolybdate assay, 11-O-Galloylbergenin was found more potent (CAHT: 940.04±115.30) as compared to α-tocopherol (CAHT: 552.4±27.91).

Nat Prod Res. 2015;29(24):2291-4.

Structure activity relationship of bergenin, p-hydroxybenzoyl bergenin, 11-O-galloylbergenin as potent antioxidant and urease inhibitor isolated from Bergenia ligulata.[Pubmed: 25674661]

METHODS AND RESULTS:
Ethanol extract of the aerial parts of Bergenia ligulata was subjected to solvent-solvent separation followed by various chromatographic techniques that lead to isolation of bergenine (1), p-hydroxybenzoyl bergenin (2), 11-O-Galloylbergenin (3) and methyl gallate (4) as major constituents. Ethyl acetate fraction showed a dose-dependent urease inhibitory pattern with IC50 value of 54μg/mL. Structures of compounds 1 and 3 were established by XRD and 2, 4 by NMR.
CONCLUSIONS:
All these compounds were subjected to DPPH scavenging activity, reducing power assay and urease inhibitory activity. The EC50 7.45 ± 0.2 μg/mL and 5.39 ± 0.28 μg/mL values in terms of antioxidant and reducing power, respectively, were less for 3. Compounds 1-3 showed moderate to significant urease inhibitory potential with IC50 57.1 ± 0.7, IC50 48.4 ± 0.3 and 38.6 ± 1.5. Antioxidant activities and urease inhibitory potential were investigated and compound 3 was found to be the most active.

In vivo:

J Ethnopharmacol. 2010 Sep 15;131(2):502-4.

Analgesic and anti-inflammatory activities of 11-O-galloylbergenin.[Pubmed: 20603209 ]

Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use.
METHODS AND RESULTS:
11-O-Galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.11-O-Galloylbergenin showed significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats. Similarly, 11-O-Galloylbergenin exhibited significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.
CONCLUSIONS:
11-O-galloylbergenin has demonstrated its significant potential to be further investigated for its discovery as a new lead compound for management of pain and inflammation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
去甲岩白菜素; Norbergenin	CFN95611	79595-97-4	C₁₃H₁₄O₉ = 314.3	20mg	QQ客服：2159513211
岩白菜素; Bergenin	CFN98724	477-90-7	C₁₄H₁₆O₉ = 328.3	20mg	QQ客服：1457312923
11-O-没食子酰岩白菜素; 11-O-Galloylbergenin	CFN96345	82958-44-9	C₂₁H₂₀O₁₃ = 480.4	5mg	QQ客服：3257982914
五乙酸岩白菜素酯; Bergenin pentaacetate	CFN99499	14531-47-6	C₂₄H₂₆O₁₄ = 538.5	5mg	QQ客服：2159513211
4-O-没食子酰岩白菜素; 4-O-Galloylbergenin	CFN96351	82958-45-0	C₂₁H₂₀O₁₃ = 480.4	5mg	QQ客服：2056216494
二-O-甲基岩白菜素; Di-O-methylbergenin	CFN98435	33815-57-5	C₁₆H₂₀O₉ = 356.3	5mg	QQ客服：3257982914
水仙环素; Narciclasine	CFN97854	29477-83-6	C₁₄H₁₃NO₇ = 307.25	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0816 mL	10.408 mL	20.816 mL	41.632 mL	52.04 mL
5 mM	0.4163 mL	2.0816 mL	4.1632 mL	8.3264 mL	10.408 mL
10 mM	0.2082 mL	1.0408 mL	2.0816 mL	4.1632 mL	5.204 mL
50 mM	0.0416 mL	0.2082 mL	0.4163 mL	0.8326 mL	1.0408 mL
100 mM	0.0208 mL	0.1041 mL	0.2082 mL	0.4163 mL	0.5204 mL

11-O-没食子酰岩白菜素

11-O-Galloylbergenin

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