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  • 10-羟基-2-癸烯酸

    10-Hydroxy-2-decenoic acid

    10-羟基-2-癸烯酸
    产品编号 CFN90512
    CAS编号 765-01-5
    分子式 = 分子量 C10H18O3 = 186.24
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Monoterpenoids
    植物来源 From Royal jelly.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    10-羟基-2-癸烯酸 CFN90512 765-01-5 10mg QQ客服:2056216494
    10-羟基-2-癸烯酸 CFN90512 765-01-5 20mg QQ客服:2056216494
    10-羟基-2-癸烯酸 CFN90512 765-01-5 50mg QQ客服:2056216494
    10-羟基-2-癸烯酸 CFN90512 765-01-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Tohoku University (Japan)
  • University of Madras (India)
  • Universidad Veracuzana (Mexico)
  • Hamdard University (India)
  • Universiti Malaysia Pahang (Malaysia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Liège (Belgium)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Bordeaux (France)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Vigo (Spain)
  • Anna University (India)
  • University of Lodz (Poland)
  • Stanford University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Foods.2021, 10(6):1378.
  • Molecules.2022, 27(19):6681.
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Pak J Pharm Sci.2018, 31:311-315
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • J Mass Spectrom.2022, 57(2):e4810.
  • Phytochemistry.2021, 181:112539.
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Molecules.2019, 24(16):E2985
  • Antibiotics.2022, 11(4), 510.
  • J Ethnopharmacol.2024, 318:116863.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Nutrients2020, 12(3):811.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Biochem Systematics and Ecology2017, 11-18
  • Phytomedicine.2022, 100:154058.
  • Rev. Chim.2020, 71(3),558-564
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Molecules.2016, 21(6)
  • University of Stuttgart2021, 11682.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • ...
  • 生物活性
    Description: 10-Hydroxy-2-decenoic acid is a potential HDACI which inhibits the proliferation of FLS cells by PI3K-AKT pathway; it exerts an inhibitory effect on VEGF-induced angiogenesis, partly by inhibiting both cell proliferation and migration. 10-Hydroxy-2-decenoic acid activates AMPK, and insulin independently enhances glucose uptake following translocation of Glut4 to PM; it also can prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions.
    Targets: AMPK | GLUT | Calcium Channel | ROS | MMP(e.g.TIMP) | JNK | p38MAPK | HDAC | PI3K | Akt | VEGFR
    In vitro:
    J Eur Acad Dermatol Venereol. 2013 Oct;27(10):1269-77.
    10-Hydroxy-2-decenoic acid prevents ultraviolet A-induced damage and matrix metalloproteinases expression in human dermal fibroblasts.[Pubmed: 23030720]
    10-Hydroxy-2-decenoic acid (10-HDA) is a major fatty acid component of royal jelly, which has been reported to have a variety of beneficial pharmacological characteristics. However, the effects of 10-HDA on skin photoageing and its potential mechanism of action are unclear. We investigated the protective effects of 10-HDA on ultraviolet (UV) A-induced damage in human dermal fibroblasts (HDFs). We then explored the inhibitory effects of 10-HDA on UVA-induced matrix metalloproteinases (MMPs) expression and elucidated the signalling pathways controlling MMPs inhibition.
    METHODS AND RESULTS:
    Primary human dermal fibroblasts were exposed to UVA. Cell proliferation, cellular senescent state and collagen content were analysed using CCK-8, senescence-associated β-galactosidase staining and Sircol collagen assay, respectively. Fluorometric assays were performed to detect the formation of reactive oxygen species (ROS) in the cells. The mRNA levels of MMP-1, MMP-3 and type I (α1) collagen were determined by quantitative real-time PCR. Western blot was applied to detect the expression of MMP-1, MMP-3, JNK and p38 MAPK. HDFs treated with 10-HDA were significantly protected from UVA-induced cytotoxicity, ROS, cellular senescence and stimulated collagen production. Moreover, 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels. Treatment with 10-HDA also reduced the UVA-induced activation of the JNK and p38 MAPK pathways.
    CONCLUSIONS:
    The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions. Therefore, 10-HDA may be a potential agent for the prevention and treatment of skin photoageing.
    Evid Based Complement Alternat Med. 2009 Dec;6(4):489-94.
    10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.[Pubmed: 18955252]
    10-Hydroxy-2-decenoic acid (10HDA), a major fatty acid component of RJ, is known to have various pharmacological effects; its antitumor activity being especially noteworthy. However, the mechanism underlying this effect is unclear.
    METHODS AND RESULTS:
    We examined the effect of 10-Hydroxy-2-decenoic acid on VEGF-induced proliferation, migration and tube formation in human umbilical vein endothelial cells (HUVECs). Our findings showed that, 10-Hydroxy-2-decenoic acid at 20 microM or more significantly inhibited such proliferation, migration and tube formation. Similarly, 10 microM GM6001, a matrix metalloprotease inhibitor, prevented VEGF-induced migration and tube formation.
    CONCLUSIONS:
    These findings indicate that 10-Hydroxy-2-decenoic acid exerts an inhibitory effect on VEGF-induced angiogenesis, partly by inhibiting both cell proliferation and migration.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.3694 mL 26.8471 mL 53.6942 mL 107.3883 mL 134.2354 mL
    5 mM 1.0739 mL 5.3694 mL 10.7388 mL 21.4777 mL 26.8471 mL
    10 mM 0.5369 mL 2.6847 mL 5.3694 mL 10.7388 mL 13.4235 mL
    50 mM 0.1074 mL 0.5369 mL 1.0739 mL 2.1478 mL 2.6847 mL
    100 mM 0.0537 mL 0.2685 mL 0.5369 mL 1.0739 mL 1.3424 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-羟基-2,6-二甲基-2,7-辛二烯酸; 6-Hydroxy-2,6-dimethyl-2,7-octadienoic acid CFN98346 28420-25-9 C10H16O3 = 184.2 5mg QQ客服:1457312923
    2,6-二甲基-7-辛烯-2,3,6-三醇; 2,6-Dimethyl-7-octene-2,3,6-triol CFN97221 73815-21-1 C10H20O3 = 188.3 5mg QQ客服:2159513211
    Betulalbuside A; Betulalbuside A CFN97110 64776-96-1 C16H28O7 = 332.4 5mg QQ客服:1413575084
    香叶醇; (E)-3,7-二甲基-2,6-辛二烯-1-醇; Geraniol CFN90489 106-24-1 C10H18O = 154.24 20mg QQ客服:1413575084
    络塞定; Rosiridin CFN99181 100462-37-1 C16H28O7 = 332.39 20mg QQ客服:1457312923
    乙酸橙花酯; Nerylacetate CFN93088 141-12-8 C12H20O2 = 196.3 20mg QQ客服:215959384
    Foliamenthoic acid; Foliamenthoic acid CFN98300 26187-80-4 C10H16O3 = 184.2 5mg QQ客服:1413575084
    10-羟基-2-癸烯酸; 10-Hydroxy-2-decenoic acid CFN90512 765-01-5 C10H18O3 = 186.24 20mg QQ客服:2159513211
    氧化芳樟醇; Linalool oxide CFN70162 60047-17-8 C10H18O2 = 170.2 20mg QQ客服:1457312923
    脱氢芳樟醇; Hotrienol CFN99583 20053-88-7 C10H16O = 152.23 5mg QQ客服:2159513211

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