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  • 10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭

    10-Deacetylbaccatin III

    10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭
    产品编号 CFN98421
    CAS编号 32981-86-5
    分子式 = 分子量 C29H36O10 = 544.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The barks of Taxus yunnanensis Cheng et L. K. Fu
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭 CFN98421 32981-86-5 10mg QQ客服:2056216494
    10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭 CFN98421 32981-86-5 20mg QQ客服:2056216494
    10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭 CFN98421 32981-86-5 50mg QQ客服:2056216494
    10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭 CFN98421 32981-86-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol. 2020, 83:106403.
  • Viruses.2017, 9(10)
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • J of Apicultural Research2020, 10.1080
  • Int J Biol Macromol.2020, 161:1230-1239.
  • PLoS One.2018, 13(4):e0195642
  • Appl. Sci. 2021, 11(10),4666.
  • Toxicol Appl Pharmacol.2021, 427:115668.
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  • Phytomedicine.2021, 83:153483.
  • BMC Complement Altern Med.2019, 19(1):325
  • Chin Med.2022, 17(1):66.
  • Int J Mol Sci.2018, 19(2)
  • Biol Pharm Bull.2018, 41(1):65-72
  • Nat Prod Commun.2014, 9(5):679-82
  • Applied Biological Chemistry2022, 65(12)
  • Sci Rep.2021, 11(1):14180.
  • Food Chem.2017, 228:301-314
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  • Nutrients2023, 15(18), 4016.
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  • ...
  • 生物活性
    Description: 10-Deacetylbacccatin III is an antineoplastic agent and an anti-cancer intermediate, it can selectively inhibit the growth of L. donovani intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC50 value of 70 nM. The 10-Deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase.
    In vitro:
    Planta Med. 2007 Aug;73(10):1081-8.
    In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes.[Pubmed: 17691059]
    Current treatments for leishmaniasis are unsatisfactory due to their route of administration, toxicity and expense but, most importantly, to the developed resistance of Leishmania to first-line drugs. Therefore, the identification of new effective targeted drugs is an urgent need. Since many studies have shown that medicinal plants contain compounds active against protozoa we have undertaken a study aiming to determine the antileishmanial activity of the taxoid 10-deacetylbaccatin III, isolated from dried needles and small branches of the European yew tree (Taxus baccata).
    METHODS AND RESULTS:
    Interestingly, 10-deacetylbaccatin III was found to selectively inhibit the growth of L. DONOVANI intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC(50) value of 70 nM. Concentrations of 10-deacetylbaccatin III as high as 5 microM did not affect J774 murine macrophages whereas 20 nM of taxol, used as a control, was toxic to macrophages. The compound also inhibited the growth of L. donovani promastigotes but at higher concentrations with a maximum level of inhibition of 35 %. Taxol inhibited promastigote growth at micromolar concentrations. Comparison of the effect of 10-deacetylbaccatin III to that of taxol on cell cycle progression and cellular morphology showed that their mechanisms of action are different.
    METHODS AND RESULTS:
    The 10-deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase. In addition 10-deacetylbaccatin III treatment, contrary to taxol, did not affect cellular morphology.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8362 mL 9.1811 mL 18.3621 mL 36.7242 mL 45.9053 mL
    5 mM 0.3672 mL 1.8362 mL 3.6724 mL 7.3448 mL 9.1811 mL
    10 mM 0.1836 mL 0.9181 mL 1.8362 mL 3.6724 mL 4.5905 mL
    50 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.7345 mL 0.9181 mL
    100 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.3672 mL 0.4591 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    14beta-苯甲酰基氧基-2-脱乙酰基巴卡丁VI; 14beta-Benzoyloxy-2-deacetylbaccatin VI CFN97197 705973-69-9 C37H46O15 = 730.8 5mg QQ客服:2159513211
    13-乙酰基-9-羟基巴卡丁III; 9-Dihydro-13-acetylbaccatin III CFN89062 142203-65-4 C33H42O12 = 630.68 20mg QQ客服:1413575084
    浆果赤霉素 VI ; Baccatin VI CFN96925 57672-79-4 C37H46O14 = 714.76 5mg QQ客服:1413575084
    浆果赤霉素 VIII ; Baccatin VIII CFN96907 1623410-10-5 C33H42O13 = 646.68 5mg QQ客服:215959384
    巴卡丁IV; Baccatin IV CFN98976 57672-77-2 C32H44O14 = 652.7 5mg QQ客服:1413575084
    10-脱乙酰基巴卡丁 III; 10-去乙酰基巴卡亭; 10-Deacetylbaccatin III CFN98421 32981-86-5 C29H36O10 = 544.6 20mg QQ客服:2159513211
    巴卡丁III; Baccatin III CFN98331 27548-93-2 C31H38O11 = 586.6 20mg QQ客服:215959384
    19-羟基浆果赤霉素III; 19-Hydroxybaccatin III CFN97267 78432-78-7 C31H38O12 = 602.6 5mg QQ客服:215959384
    7-木糖基-10-去乙酰基巴卡亭Ⅲ; 7-Xylosyl-10-deacetylbaccatin III CFN89390 157664-03-4 C34H44O14 = 676.70 5mg QQ客服:1457312923
    浆果赤霉素 IX ; Baccatin IX CFN96908 1623410-12-7 C31H40O12 = 604.64 5mg QQ客服:2159513211

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