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  • 1beta-羟基土木香内酯

    1beta-Hydroxyalantolactone

    1beta-羟基土木香内酯
    产品编号 CFN92600
    CAS编号 68776-47-6
    分子式 = 分子量 C15H20O3 = 248.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Inula japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1beta-羟基土木香内酯 CFN92600 68776-47-6 1mg QQ客服:2056216494
    1beta-羟基土木香内酯 CFN92600 68776-47-6 5mg QQ客服:2056216494
    1beta-羟基土木香内酯 CFN92600 68776-47-6 10mg QQ客服:2056216494
    1beta-羟基土木香内酯 CFN92600 68776-47-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Tokyo Woman's Christian University (Japan)
  • University of Minnesota (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Colorado State University (USA)
  • MTT Agrifood Research Finland (Finland)
  • Texas A&M University (USA)
  • University of Illinois at Chicago (USA)
  • Universidade da Beira Interior (Germany)
  • Srinakharinwirot University (Thailand)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Illinois (USA)
  • University of Hertfordshire (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomed Sci Letters.2020, 26:319-326
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • University of Limpopo2016, 1-237
  • Mediators Inflamm.2016, 2016:7216912
  • Plant Pathology2022, 10.1111:ppa.13651.
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Int J Mol Sci.2021, 22(19):10220.
  • Eur J Pharmacol.2020, 889:173589.
  • Foods.2021, 10(11):2754.
  • Nutraceuticals2022, 2(3),150-161
  • J Breast Cancer.2015, 18(2):112-118
  • Eur J Pharmacol.2018, 832:96-103
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • J Nat Med.2021, doi: 10.1007.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Int J Mol Sci.2022, 23(21):12816.
  • Sci Rep.2019, 9:19059
  • Agriculture2022, 12(12), 2173.
  • Biol Pharm Bull.2018, 41(1):65-72
  • Front Pharmacol.2021, 12:690113.
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Natural Product Communications2020, doi: 10.1177.
  • ...
  • 生物活性
    Description: 1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
    Targets: IL Receptor | TNF-α | NF-kB
    In vivo:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:40-5.
    Simultaneous determination of three sesquiterpene lactones from Herba Inula extract in rat plasma by LC/MS/MS and its application to pharmacokinetic study.[Pubmed: 22819204]

    METHODS AND RESULTS:
    A rapid and sensitive liquid chromatography-tandem mass spectrometry method has been developed and validated for the determination of 1-acetoxy-6α-hydroxyeriolanolide, 1beta-Hydroxyalantolactone and ivangustin from Herba Inula extract in rat plasma. Calibration curves were linear over the concentration range of 4-800 ng/mL for 1-acetoxy-6α-hydroxyeriolanolide, 8-500 ng/mL for 1beta-Hydroxyalantolactone and ivangustin. The limit of detection (LOD) was 1 ng/mL for 1-acetoxy-6α-hydroxyeriolanolide, 1.6 ng/mL for 1beta-Hydroxyalantolactone and ivangustin (S/N=3).
    CONCLUSIONS:
    The method was successfully applied to pharmacokinetic studies of the three sesquiterpene lactones after oral administration of 300 mg/kg Herba Inula extract to rats, the t(½) of 1-acetoxy-6α-hydroxyeriolanolide, 1beta-Hydroxyalantolactone and ivangustin was 9.65±1.43, 14.88±0.82 and 13.93±2.74 (h). The AUC((0-t)) of 1-acetoxy-6α-hydroxyeriolanolide, 1beta-Hydroxyalantolactone and ivangustin was 1102.46±247.04, 808.92±117.53 and 990.35±275.49 (ng h/mL), respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0274 mL 20.1369 mL 40.2739 mL 80.5477 mL 100.6847 mL
    5 mM 0.8055 mL 4.0274 mL 8.0548 mL 16.1095 mL 20.1369 mL
    10 mM 0.4027 mL 2.0137 mL 4.0274 mL 8.0548 mL 10.0685 mL
    50 mM 0.0805 mL 0.4027 mL 0.8055 mL 1.611 mL 2.0137 mL
    100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8055 mL 1.0068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    别土木香内酯; Alloalantolactone CFN91880 64340-41-6 C15H20O2 = 232.32 10mg QQ客服:2159513211
    狭叶依瓦菊素; Ivangustin CFN92599 14164-59-1 C15H20O3 = 248.3 10mg QQ客服:1457312923
    土木香内酯; Alantolactone CFN99934 546-43-0 C15H20O2 = 232.32 20mg QQ客服:215959384
    1beta-羟基土木香内酯; 1beta-Hydroxyalantolactone CFN92600 68776-47-6 C15H20O3 = 248.3 10mg QQ客服:1457312923
    异土木香内酯; Isoalantolactone CFN98107 470-17-7 C16H20O2 = 232.32 20mg QQ客服:2159513211
    11,13-二氢依瓦菊林; 11,13-Dihydroivalin CFN97819 150150-61-1 C15H22O3 = 250.34 5mg QQ客服:2159513211

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