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  • 1,4-二咖啡酰奎宁酸

    1,4-Dicaffeoylquinic acid

    1,4-二咖啡酰奎宁酸
    产品编号 CFN99122
    CAS编号 1182-34-9
    分子式 = 分子量 C25H24O12 = 516.46
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The flowerbud of Lonicera japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,4-二咖啡酰奎宁酸 CFN99122 1182-34-9 1mg QQ客服:2056216494
    1,4-二咖啡酰奎宁酸 CFN99122 1182-34-9 5mg QQ客服:2056216494
    1,4-二咖啡酰奎宁酸 CFN99122 1182-34-9 10mg QQ客服:2056216494
    1,4-二咖啡酰奎宁酸 CFN99122 1182-34-9 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Cancer Center Research Institute (Japan)
  • Rio de Janeiro State University (Brazil)
  • Chulalongkorn University (Thailand)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • National Chung Hsing University (Taiwan)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Utah State University (USA)
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  • Heidelberg University (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Fribourg (Switzerland)
  • MTT Agrifood Research Finland (Finland)
  • Georgia Institute of Technology (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Arch Biochem Biophys.2018, 644:93-99
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Applied Biological Chemistry2023, 66:85.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Phytother Res.2022, 35844057.
  • Processes2021, 9(11),2065.
  • Nutrients.2023, 15(13):2960.
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • Exp Ther Med.2019, 18(6):4388-4396
  • Phytother Res.2022, ptr.7573.
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Appl. Sci.2020, 10(5),1713.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Preprints2021, doi:10.20944
  • Vietnam Journal of Science2022,64(2):69-75.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Cell Rep.2020, 32(11):108158.
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Nutr Cancer.2022, 1-13.
  • Phytochemistry.2017, 141:162-170
  • Natural Product Communications2021, 16(9):1-10.
  • ...
  • 生物活性
    Description: 1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentrations.1,4-Dicaffeoylquinic acid also has antioxidant activity.
    Targets: HIV
    In vitro:
    Pharmacogn Mag . 2015 Oct;11(Suppl 4):S585-91.
    Phytochemical Analysis on Quantification and the Inhibitory Effects on Inflammatory Responses from the Fruit of Xanthii fructus[Pubmed: 27013799]
    Abstract Objective: Xanthii fructus (Compositae) is a traditional herbal medicine used for treating headache, toothache, pruritus, empyema, and rhinitis. In this study of the quality control of X. fructus, we performed simultaneous analysis of nine marker compounds: Protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), 4,5-dicaffeoylquinic acid (4), ferulic acid (5), 3,5-dicaffeoylquinic acid (6), 1,3-dicaffeoylquinic acid (7), 1,4-dicaffeoylquinic acid (8), and 4,5-dicaffeoylquinic acid (9). Materials and methods: Nine components were separated using reversed-phase SunFire™ C18 analytical column and analyzed using high-performance liquid chromatography. We examined the biological effects of the nine marker compounds by determining their anti-inflammatory activities in the murine macrophage cell line RAW 264.7. Results: Among the nine marker compounds, eight significantly inhibited lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-α) production. 1, 3, 5 had significant inhibitory effects on LPS-induced prostaglandin E2 (PGE2) production in RAW 264.7 cells. None of the tested marker compounds had a significant effect on interleukin-6 production in LPS-treated RAW 264.7 cells. Our data demonstrated that each marker compound from X. fructus exerts anti-inflammatory activity by targeting different inflammation-related pathways such as the TNF-α or PGE2 pathway. Conclusion: Further experiments using in vitro and in vivo models are needed to identify the mechanisms responsible for the anti-inflammatory properties of each marker compound. Summary: Simultaneous analysis of nine phenylpropanoids in the Xanthii fructus was established using HPLC-PDA system.1,4-dicaffeoylquinic acid significantly inhibited LPS-stimulated TNF-a production.Protocatechuic acid, caffeic acid and ferulic acid had significant inhibitory effects on LPS-induced PGE2 production in RAW 264.7 cells. Keywords: Anti-inflammatory effect; RAW 264.7; Xanthii fructus; herbal medicine; high-performance liquid chromatography.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9363 mL 9.6813 mL 19.3626 mL 38.7252 mL 48.4065 mL
    5 mM 0.3873 mL 1.9363 mL 3.8725 mL 7.745 mL 9.6813 mL
    10 mM 0.1936 mL 0.9681 mL 1.9363 mL 3.8725 mL 4.8406 mL
    50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7745 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3873 mL 0.4841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate CFN91970 143051-73-4 C27H28O12 = 544.50 5mg QQ客服:1413575084
    3,4-O-二咖啡酰基奎宁酸甲酯; 3,4-Di-O-caffeoylquinic acid methyl ester CFN90856 114637-83-1 C26H26O12 = 530.5 5mg QQ客服:1413575084
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:1457312923
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:3257982914
    3,5-O-二咖啡酰基奎宁酸甲酯; 3,5-Di-O-caffeoylquinic acid methyl ester CFN90857 159934-13-1 C26H26O12 = 530.5 5mg QQ客服:215959384
    异绿原酸C; Isochlorogenic acid C CFN99120 32451-88-0 C25H24O12 = 516.45 20mg QQ客服:1413575084
    异绿原酸C 4'-O-葡萄糖; Isochlorogenic acid C 4'-O-glucoside CFN95405 N/A C31H34O17 = 678.6 5mg QQ客服:2056216494
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:2056216494
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:2056216494
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 20mg QQ客服:1413575084

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