1,3,5-三羟基咕吨酮

1,3,5-Trihydroxyxanthone

	产品编号	CFN92399
	CAS编号	6732-85-0
	分子式 = 分子量	C₁₃H₈O₅ = 244.2
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Xanthones
	植物来源	The herbs of Calophyllum inophyllum L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
1,3,5-三羟基咕吨酮	CFN92399	6732-85-0	1mg	QQ客服：2159513211
1,3,5-三羟基咕吨酮	CFN92399	6732-85-0	5mg	QQ客服：2159513211
1,3,5-三羟基咕吨酮	CFN92399	6732-85-0	10mg	QQ客服：2159513211
1,3,5-三羟基咕吨酮	CFN92399	6732-85-0	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universiti Putra Malaysia(UPM) (Malaysia)

Charles University in Prague (Czech Republic)

University of Illinois (USA)

Deutsches Krebsforschungszentrum (Germany)

Universitas islam negeri Jakarta (Indonesia)

National Cancer Center Research Institute (Japan)

University of Wuerzburg (Germany)

University of Wollongong (Australia)

Sant Gadge Baba Amravati University (India)

Florida A&M University (USA)

Aarhus University (Denmark)

China Medical University (Taiwan)

Indian Institute of Science (India)

Tohoku University (Japan)

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Description:

1,3,5-Trihydroxyxanthone has selective inhibitory activity on platelet aggregation induced by adenosine diphosphate.

In vitro:

Phytochemistry. 2012 Aug;80:58-63.

Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation.[Pubmed: 22640928]

METHODS AND RESULTS:
Three benzophenones, 2,6,3',5'-tetrahydroxybenzophenone (1), 3,4,5,3',5'-pentahydroxybenzophenone (3) and 3,5,3',5'-tetrahydroxy-4-methoxybenzophenone (4), as well as a xanthone, 1,3,6-trihydroxy-5-methoxy-7-(3'-methyl-2'-oxo-but-3'-enyl)xanthone (9), were isolated from the twigs of Garcinia cantleyana var. cantleyana. Eight known compounds, 3,4,5,3'-tetrahydroxy benzophenone (2), 1,3,5-Trihydroxyxanthone (5), 1,3,8-trihydroxyxanthone (6), 2,4,7-trihydroxyxanthone (7), 1,3,5,7-tetrahydroxyxanthone (8), quercetin, glutin-5-en-3β-ol and friedelin were also isolated. The structures of the compounds were elucidated by spectroscopic methods. The compounds were investigated for their ability to inhibit low-density lipoprotein (LDL) oxidation and platelet aggregation in human whole blood in vitro. Most of the compounds showed strong antioxidant activity with compound 8 showing the highest inhibition with an IC₅₀ value of 0.5 μM, comparable to that of probucol.
CONCLUSIONS:
Among the compounds tested, only compound 4 exhibited strong inhibitory activity against platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen. Compounds 3, 5 and 8 showed selective inhibitory activity on platelet aggregation induced by ADP.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
雏菊叶龙胆酮; Bellidifolin	CFN89132	2798-25-6	C₁₄H₁₀O₆ = 274.22	10mg	QQ客服：1457312923
1,3,7-三羟基-9H-氧杂蒽-9-酮; Gentisein	CFN92398	529-49-7	C₁₃H₈O₅ = 244.2	5mg	QQ客服：3257982914
1,3,5-三羟基咕吨酮; 1,3,5-Trihydroxyxanthone	CFN92399	6732-85-0	C₁₃H₈O₅ = 244.2	5mg	QQ客服：215959384
1,3,5,6-四羟基氧杂蒽酮; 1,3,5,6-Tetrahydroxyxanthone	CFN92539	5084-31-1	C₁₃H₈O₆ = 260.2	5mg	QQ客服：1457312923
1,3,6-三羟基-5-甲氧基氧杂蒽酮; 1,3,6-Trihydroxy-5-methoxyxanthone	CFN92540	41357-84-0	C₁₄H₁₀O₆ = 274.2	5mg	QQ客服：215959384
3,8-二羟基-2,4,6-三甲氧基氧杂蒽酮; 3,8-Dihydroxy-2,4,6-trimethoxyxanthone	CFN92556	65008-17-5	C₁₆H₁₄O₇ = 318.3	5mg	QQ客服：1413575084
1,6,7-三羟基氧杂蒽酮; 1,6,7-Trihydroxyxanthone	CFN98284	25577-04-2	C₁₃H₈O₅ = 244.2	5mg	QQ客服：1457312923
1,3,6,7-四羟基氧杂蒽酮; Norathyriol	CFN98468	3542-72-1	C₁₃H₈O₆ = 260.2	5mg	QQ客服：1413575084
Montixanthone; Montixanthone	CFN91903	876305-36-1	C₁₄H₁₀O₆ = 274.23	5mg	QQ客服：2056216494
3,6-二羟基-1,7-二甲氧基呫吨酮; 3,6-Dihydroxy-1,7-dimethoxyxanthone	CFN89303	262292-34-2	C₁₅H₁₂O₆ = 288.25	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.095 mL	20.475 mL	40.95 mL	81.9001 mL	102.3751 mL
5 mM	0.819 mL	4.095 mL	8.19 mL	16.38 mL	20.475 mL
10 mM	0.4095 mL	2.0475 mL	4.095 mL	8.19 mL	10.2375 mL
50 mM	0.0819 mL	0.4095 mL	0.819 mL	1.638 mL	2.0475 mL
100 mM	0.041 mL	0.2048 mL	0.4095 mL	0.819 mL	1.0238 mL