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  • 木防己宁碱

    Trilobinine

    木防己宁碱
    产品编号 CFN92948
    CAS编号 126595-92-4
    分子式 = 分子量 C20H24NO4+ = 342.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Cocculus orbiculatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    木防己宁碱 CFN92948 126595-92-4 1mg QQ客服:3257982914
    木防己宁碱 CFN92948 126595-92-4 5mg QQ客服:3257982914
    木防己宁碱 CFN92948 126595-92-4 10mg QQ客服:3257982914
    木防己宁碱 CFN92948 126595-92-4 20mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    IF=22.415(2019)

    PMID: 32004475

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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
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  • J Pharm Biomed Anal2016, 118:183-194
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  • J Ethnopharmacol.2017, 198:87-90
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  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Anticancer Res.2018, 38(4):2127-2135
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  • Clin Transl Oncol.2019, 10.1007
  • Biomed Pharmacother.2019, 116:108987
  • Neuropharmacology2019, 151437
  • Food Chem.2019, 279:80-87
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  • Int J Oncol.2019, 55(1):320-330
  • Biomed Chromatogr.2019, 8:e4774
  • Sci Rep.2019, 9(1):18080
  • ...
  • 生物活性
    Description: (+)-Trilobinine has relaxant effects via the activation of beta 2-adrenoceptors, it can reduce the spontaneous tone and inhibit the contractions induced by carbachol and histamine.
    Targets: Adrenergic Receptor
    In vivo:
    Planta Med. 1999 Jun;65(5):462-4.
    Tracheal relaxant activity of cissaglaberrimine and trilobinine, two aporphinic alkaloids from Cissampelos glaberrima.[Pubmed: 10418339]
    In the present work we studied the relaxant effect of two aporphinic alkaloids isolated from the roots barks of Cissampelos glaberrima St. Hil. (Menispermaceae), (+)-cissaglaberrimine (CGE; a tertiary alkaloid) and (+)-Trilobinine (TBE; a quaternary alkaloid).
    METHODS AND RESULTS:
    In guinea-pig tracheal preparations, CGE and TBE reduced the spontaneous tone and inhibited the contractions induced by carbachol and histamine. TBE was 6 times more potent than CGE in reducing the spontaneous tone and it was also 1.5 times more potent in antagonising the effects of carbachol and histamine. The inhibitory effect of CGE in contractions induced by histamine was not attenuated in the presence of timolol (10 microM). However, in the same experimental conditions, timolol almost completely abolished the inhibitory effect of TBE.
    CONCLUSIONS:
    These results showed that the relaxations induced by TBE were dependent on the activation of beta 2-adrenoceptors, while the mechanism involved in relaxations induced by CGE remains to be determined.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9205 mL 14.6024 mL 29.2048 mL 58.4095 mL 73.0119 mL
    5 mM 0.5841 mL 2.9205 mL 5.841 mL 11.6819 mL 14.6024 mL
    10 mM 0.292 mL 1.4602 mL 2.9205 mL 5.841 mL 7.3012 mL
    50 mM 0.0584 mL 0.292 mL 0.5841 mL 1.1682 mL 1.4602 mL
    100 mM 0.0292 mL 0.146 mL 0.292 mL 0.5841 mL 0.7301 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化木兰花碱; Magnoflorine chloride CFN90259 6681-18-1 C20H24NO4Cl = 377.87 20mg QQ客服:2932563308
    竹叶椒碱; Xanthoplanine CFN97169 6872-88-4 C21H26NO4 = 356.4 5mg QQ客服:2932563308
    樟叶木防己碱; Laurifoline CFN97205 7224-61-5 C20H24NO4 = 342.4 5mg QQ客服:1413575084
    木兰花碱; Magnoflorine CFN98071 2141-09-5 C20H24NO4 = 342.4 20mg QQ客服:2932563308
    N-Methylcorydinium iodide; N-Methylcorydinium iodide CFN92891 4668-64-6 C21H26NO4 = 356.43 5mg QQ客服:1413575084
    木防己宁碱; Trilobinine CFN92948 126595-92-4 C20H24NO4+ = 342.41 5mg QQ客服:2932563308

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