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  • 竹叶椒碱

    Xanthoplanine

    竹叶椒碱
    产品编号 CFN97169
    CAS编号 6872-88-4
    分子式 = 分子量 C21H26NO4 = 356.4
    产品纯度 >=98%
    物理属性 Brown powder
    化合物类型 Alkaloids
    植物来源 The roots of Zanthoxylum armatum DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    竹叶椒碱 CFN97169 6872-88-4 1mg QQ客服:215959384
    竹叶椒碱 CFN97169 6872-88-4 5mg QQ客服:215959384
    竹叶椒碱 CFN97169 6872-88-4 10mg QQ客服:215959384
    竹叶椒碱 CFN97169 6872-88-4 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Liège (Belgium)
  • Korea Food Research Institute(KFRI) (Korea)
  • The Australian National University (Australia)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Hawaii Cancer Center (USA)
  • Charles University in Prague (Czech Republic)
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  • University of Mysore (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • John Innes Centre (United Kingdom)
  • University of Maryland (USA)
  • University of Brasilia (Brazil)
  • VIT University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Korea Society of Pha.2014, 300-314
  • Industrial Food Engineering2015, 19(4):408-413
  • Molecules.2015, 20(11):20014-30
  • Phytother Res.2015, 29(7):1088-96
  • Inflammation.2015, 38(4):1502-16
  • J Pharm Biomed Anal.2016, 129:50-59
  • Chemistr of plant2016, 2016021195
  • Braz J Med Biol Res. 2016, 49(7)
  • Nat Prod Sci.2018, 24(2):109-114
  • Anat Rec2018, 24264
  • South African J of Plant&Soil2018, 29-32
  • Sci Adv.2018, 4(10)
  • Food and Fermentation Industries2018, 44(371)
  • Cell Death Dis.2019, 10(12):882
  • Drug Invention Today2019, 12(6):1303-1306
  • Chemistry of Plant Materials.2019, 129-136
  • Plant Physiol Biochem.2019, 144:355-364
  • BMC Complement Altern Med.2019, 19(1):367
  • Molecules.2019, 24(4):E744
  • J Ethnopharmacol.2019, 244:112074
  • Molecules.2019, 25(1):E103
  • Phytother Res.2019, 33(5):1490-1500
  • Korean J of Crop Science2019, 452-458
  • ...
  • 生物活性
    Description: Xanthoplanine fully inhibits the EC(50) ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC(50) values of 9+/-3 microM (alpha7) and 5+/-0.8 microM (alpha4beta2).
    Targets: AChR
    In vitro:
    Bioorg Med Chem. 2007 May 15;15(10):3368-72.
    Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.[Pubmed: 17391965]

    METHODS AND RESULTS:
    (S)-Aporphine metho salts with the 1,2,9,10 oxygenation pattern displaced radioligands from recombinant human alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors (nAChR) at low micromolar concentrations. The affinity of the nonphenolic glaucine methiodide (4) (vs [(3)H]cytisine) was the lowest at alpha4beta2 nAChR (K(i)=10 microM), and predicentrine methiodide (2) and Xanthoplanine iodide (3), with free hydroxyl groups at C-2 or C-9, respectively, had the highest affinity at these receptors (K(i) approximately 1 microM), while the affinity of the diphenolic boldine methiodide (1) was intermediate between these values. At homomeric alpha7 nAChR, Xanthoplanine had the highest affinity (K(i)=10 microM) vs [(125)I]alpha-bungarotoxin while the other three compounds displaced the radioligand with K(i) values between 15 and 21 microM. At 100 microM, all four compounds inhibited the responses of these receptors to EC(50) concentrations of ACh.
    CONCLUSIONS:
    The effects of Xanthoplanine iodide (3) were studied in more detail. Xanthoplanine fully inhibited the EC(50) ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC(50) values of 9+/-3 microM (alpha7) and 5+/-0.8 microM (alpha4beta2).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8058 mL 14.0292 mL 28.0584 mL 56.1167 mL 70.1459 mL
    5 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
    10 mM 0.2806 mL 1.4029 mL 2.8058 mL 5.6117 mL 7.0146 mL
    50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.5612 mL 0.7015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化木兰花碱; Magnoflorine chloride CFN90259 6681-18-1 C20H24NO4Cl = 377.87 20mg QQ客服:1413575084
    竹叶椒碱; Xanthoplanine CFN97169 6872-88-4 C21H26NO4 = 356.4 5mg QQ客服:215959384
    樟叶木防己碱; Laurifoline CFN97205 7224-61-5 C20H24NO4 = 342.4 5mg QQ客服:2159513211
    木兰花碱; Magnoflorine CFN98071 2141-09-5 C20H24NO4 = 342.4 20mg QQ客服:215959384
    N-Methylcorydinium iodide; N-Methylcorydinium iodide CFN92891 4668-64-6 C21H26NO4 = 356.43 5mg QQ客服:1413575084
    木防己宁碱; Trilobinine CFN92948 126595-92-4 C20H24NO4+ = 342.41 5mg QQ客服:215959384

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