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  • 苏铁双黄酮

    Sotetsuflavone

    苏铁双黄酮
    产品编号 CFN93257
    CAS编号 2608-21-1
    分子式 = 分子量 C31H20O10 = 552.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Selaginella tamariscina
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苏铁双黄酮 CFN93257 2608-21-1 1mg QQ客服:2932563308
    苏铁双黄酮 CFN93257 2608-21-1 5mg QQ客服:2932563308
    苏铁双黄酮 CFN93257 2608-21-1 10mg QQ客服:2932563308
    苏铁双黄酮 CFN93257 2608-21-1 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Griffith University (Australia)
  • Anna University (India)
  • Charles Sturt University (Denmark)
  • Technical University of Denmark (Denmark)
  • University of Wuerzburg (Germany)
  • Julius Kühn-Institut (Germany)
  • University of Hertfordshire (United Kingdom)
  • Chulalongkorn University (Thailand)
  • Sant Gadge Baba Amravati University (India)
  • Florida International University (USA)
  • Aveiro University (Portugal)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • National Hellenic Research Foundation (Greece)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • Korean Journal of Pharmacognosy2014, 113-120
  • Braz J Med Biol Res. 2016, 49(7)
  • Planta Med.2016, 82(13):1208-16
  • Phytochemistry.2017, 141:162-170
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Journal of Life Science2017, 233-240
  • Food Res Int.2018, 106:909-919
  • Molecules.2018, 23(9):E2121
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Virulence.2018, 9(1):588-603
  • Wageningen University & Research2018, January 2018
  • Saf Health Work.2019, 10(2):196-204
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Food and Agriculture Org. Of the UN2019, 151-160
  • BMC Complement Altern Med.2019, 19(1):367
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • J Ethnopharmacol.2019, 235:406-414
  • Molecules.2019, 24(11):E2044
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Ann Transl Med.2019, 7(23):731
  • Br J Pharmacol.2020, 10.1111
  • Industrial Crops and Products2020, 146:112186
  • ...
  • 生物活性
    Description: Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 uM, is the most active compound of this series.
    Targets: DENV-NS5 RdRp
    In vitro:
    Planta Med. 2013 Sep;79(14):1313-8.
    Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.[Pubmed: 23929244 ]
    Dengue virus is the world's most prevalent human pathogenic arbovirus. There is currently no treatment or vaccine, and solutions are urgently needed. We previously demonstrated that biflavonoids from Dacrydium balansae, an endemic gymnosperm from New Caledonia, are potent inhibitors of the Dengue virus NS5 RNA-dependent RNA polymerase.
    METHODS AND RESULTS:
    Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl-amentoflavone (11), cupressuflavone (12), and apigenin derivatives (13-23). We conclude that 1) over the four different biflavonoid skeletons tested, amentoflavone (1) and robustaflavone (5) are the most promising ones for antidengue drug development, 2) the number and position of methyl groups on the biflavonoid moiety modulate their inhibition of Dengue virus NS5 RNA-dependent RNA polymerase, and 3) the degree of oxygenation of flavonoid monomers influences their antidengue potential.
    CONCLUSIONS:
    Sotetsuflavone (8), with an IC50 = 0.16 μM, is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase described in the literature.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.81 mL 9.0498 mL 18.0995 mL 36.1991 mL 45.2489 mL
    5 mM 0.362 mL 1.81 mL 3.6199 mL 7.2398 mL 9.0498 mL
    10 mM 0.181 mL 0.905 mL 1.81 mL 3.6199 mL 4.5249 mL
    50 mM 0.0362 mL 0.181 mL 0.362 mL 0.724 mL 0.905 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.362 mL 0.4525 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',4'''-双-O-甲基姜黄素; 4',4'''-Di-O-methylcupressuflavone CFN97224 74336-91-7 C32H22O10 = 566.5 5mg QQ客服:2159513211
    8,8''-二黄芩素; 8,8''-Bibaicalein CFN95007 135309-02-3 C30H18O10 = 538.5 5mg QQ客服:1413575084
    Acuminatanol; Acuminatanol CFN96555 948884-38-6 C30H22O16 = 638.49 5mg QQ客服:2159513211
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether; 2,3-Dihydroamentoflavone 7,4'-dimethyl ether CFN96163 873999-88-3 C32H24O10 = 568.5 5mg QQ客服:1413575084
    2,3-二羟基三叶橡胶黄酮; 2,3-Dihydroheveaflavone CFN96119 110382-42-8 C33H26O10 = 582.6 5mg QQ客服:1413575084
    2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin CFN96134 34421-19-7 C33H26O10 = 582.6 5mg QQ客服:215959384
    2,3-二氢罗汉松黄酮A; 2,3-Dihydropodocarpusflavone A CFN96378 852875-96-8 C31H22O10 = 554.5 5mg QQ客服:2932563308
    四氢阿曼托黄素; Tetrahydroamentoflavone CFN98755 48236-96-0 C30H22O10 = 542.5 5mg QQ客服:215959384
    穗花杉双黄酮; 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服:1148253675
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:1148253675

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