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  • 三叶橡胶黄酮

    Heveaflavone

    三叶橡胶黄酮
    产品编号 CFN98236
    CAS编号 23132-13-0
    分子式 = 分子量 C33H24O10 = 580.6
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Selaginella tamariscina (P. Beauv.) Spring
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三叶橡胶黄酮 CFN98236 23132-13-0 1mg QQ客服:3257982914
    三叶橡胶黄酮 CFN98236 23132-13-0 5mg QQ客服:3257982914
    三叶橡胶黄酮 CFN98236 23132-13-0 10mg QQ客服:3257982914
    三叶橡胶黄酮 CFN98236 23132-13-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Donald Danforth Plant Science Center (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Oslo (Norway)
  • University of Wuerzburg (Germany)
  • Anna University (India)
  • Universiti Malaysia Pahang (Malaysia)
  • National Hellenic Research Foundation (Greece)
  • Almansora University (Egypt)
  • University of Pretoria (South Africa)
  • Universidade do Porto (Portugal)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Sapienza University of Rome (Italy)
  • University of Dicle (Turkey)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Research International2020, 108987
  • Institute of Food Science & Technology2021, 18 December.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • Earth Environ. Sci. 2021, 905:012080.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Int J Mol Sci.2021, 22(19):10405.
  • Pharmaceutics.2022, 14(5):945.
  • Nutrients.2019, 11(4):E936
  • J Sep Sci.2020, 43(22):4148-4161.
  • Int J Mol Sci.2020, 21(9):3239.
  • J Separation Science & Technology2016, 51:1579-1588
  • Anticancer Res.2014, 34(7):3505-9
  • Anal Chim Acta.2018, 1039:162-171
  • ACS Omega2020, 5,33,20825-20830
  • Molecules.2015, 20(10):19172-88
  • Separations2023, 10(11), 567;
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Food Chem.2019, 278:683-691
  • Int J Cosmet Sci.2019, 41(1):12-20
  • J Appl Biol Chem2023, 66:455−461
  • Nutrients.2022, 14(16):3393.
  • Cancers (Basel).2021, 13(17):4327.
  • ...
  • 生物活性
    Description: Heveaflavone has anti-proliferation effects, it shows moderate Topoisomerase I inhibitory activity. It also possesses a good antioxidant activity via its DPPH free radical scavenging.
    Targets: Topoisomerase
    In vitro:
    Phytochem Anal. 2014 Mar-Apr;25(2):127-33.
    Preparative isolation of six anti-tumour biflavonoids from Selaginella doederleinii Hieron by high-speed counter-current chromatography.[Pubmed: 24115163]
    Biflavonoids are the primary constituents of Selaginella doederleinii Hieron, to which different bioactivities have been attributed, including anti-cancer, anti-inflammatory, anti-oxidant, anti-fungal and anti-virus activity. However, effective methods for separation of these compounds are not currently available. To develop a high performance and bioassay-guided method for preparative isolation of biflavonoids from S. doederleini via high-speed counter-current chromatography (HSCCC).
    METHODS AND RESULTS:
    The anti-proliferation effects of four fractions (70% ethanol, petroleum ether, dichloromethane and acetic ether extracts) of S. doederleinii on five human cancer cells were monitored. The dichloromethane and acetic ether extracts showed good cytotoxicities to the studied cancer cell lines, guiding the subsequent separation. Two solvent systems composed of n-hexane:ethyl acetate:methanol:water (1:2:1.5:1.5, v/v) and n-hexane:ethyl acetate:methanol:water (3:2:3:2, v/v) were developed for separation of the active fractions, respectively. Identification of the biflavonoids was performed by EI-MS(n) , (1) H- and (13) C-NMR. Under the optimised conditions, 12.6 mg amentoflavone (91.4%), 6.6 mg robustaflavone (90.4%), 7.5 mg 2'', 3''-dihydro-3', 3'''-biapigenin (98.2%) and 7.3 mg 3', 3'''-binaringenin (90.3%) from acetic ether extract (500 mg) and 6.3 mg heveaflavone (93.5%) and 5.3 mg 7, 4', 7'', 4'''-tetra-O-methyl-amentoflavone (94.5%) from dichloromethane extract (200 mg) were obtained, respectively. The anti-proliferation effects of the six biflavonoids on the five human cancer cells were further verified.
    CONCLUSIONS:
    The study provides methodological references for simultaneously preparative isolation of several bioactive biflavones from the herbal family of Selaginella. It is the first report discovering 2'', 3''-dihydro-3', 3'''-biapigenin and 3', 3'''-binaringenin from this herb and describing their cytotoxicities to human cancer cell lines.
    J Tradit Complement Med. 2012 Jul;2(3):220-6.
    Naturally Occurring Cytotoxic [3'→8″]-Biflavonoids from Podocarpus nakaii.[Pubmed: 24716136]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3'→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values.
    CONCLUSIONS:
    Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7224 mL 8.6118 mL 17.2236 mL 34.4471 mL 43.0589 mL
    5 mM 0.3445 mL 1.7224 mL 3.4447 mL 6.8894 mL 8.6118 mL
    10 mM 0.1722 mL 0.8612 mL 1.7224 mL 3.4447 mL 4.3059 mL
    50 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.6889 mL 0.8612 mL
    100 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3',3'''-二柚皮素; 3',3'''-Binaringenin CFN95558 145399-99-1 C30H22O10 = 542.5 5mg QQ客服:1457312923
    穗花杉双黄酮; 阿曼托黄酮; Amentoflavone CFN99526 1617-53-4 C30H18O10 = 538.46 20mg QQ客服:3257982914
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:2159513211
    红杉双黄酮; Sequoiaflavone CFN95642 21763-71-3 C31H20O10 = 552.5 5mg QQ客服:3257982914
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:2159513211
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:215959384
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:1413575084
    竹柏双黄酮B; Putraflavone CFN98246 23624-21-7 C32H22O10 = 566.5 5mg QQ客服:1457312923
    三叶橡胶黄酮; Heveaflavone CFN98236 23132-13-0 C33H24O10 = 580.6 5mg QQ客服:1413575084
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服:215959384

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