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  • 穗花杉双黄酮; 阿曼托黄酮

    Amentoflavone

    穗花杉双黄酮; 阿曼托黄酮
    产品编号 CFN99526
    CAS编号 1617-53-4
    分子式 = 分子量 C30H18O10 = 538.46
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    穗花杉双黄酮; 阿曼托黄酮 CFN99526 1617-53-4 10mg QQ客服:215959384
    穗花杉双黄酮; 阿曼托黄酮 CFN99526 1617-53-4 20mg QQ客服:215959384
    穗花杉双黄酮; 阿曼托黄酮 CFN99526 1617-53-4 50mg QQ客服:215959384
    穗花杉双黄酮; 阿曼托黄酮 CFN99526 1617-53-4 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Universidad Miguel Hernández (Spain)
  • University of Zurich (Switzerland)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Donald Danforth Plant Science Center (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Universidad Veracuzana (Mexico)
  • University of Ioannina (Greece)
  • University of Illinois at Chicago (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Colorado State University (USA)
  • Universidad de Buenos Aires (Argentina)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Sci. Rep.2015, 14-23
  • J Breast Cancer.2015, 18(2):112-118
  • Acta Agriculturae Scandinavica2015, 381-383
  • J Ethnopharmacol.2016, 192:370-381
  • Int J Mol Med.2016, 37(2):501-8
  • Biochem Systematics and Ecology2017, 11-18
  • Tea Res. Ins. Of China2017, 1-12
  • Current Pharmaceutical Analysis2017, 13(5)
  • Phytochemistry.2017, 141:162-170
  • Sci Rep. 2017, 8207(7)
  • Drug Test Anal.2018, 10(10):1579-1589
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Mol Cells.2018, 41(8):771-780
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Clin Transl Oncol.2019, 10.1007
  • Biomol Ther (Seoul).2019, 10.4062
  • Int J Mol Sci.2019, 20(21):E5488
  • Cell Chem Biol.2019, 26(1):27-34
  • Chem Biol Interact.2019, 315:108910
  • Phytomedicine.2019, 55:229-237
  • Biomed Chromatogr.2019, 8:e4774
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Amentoflavone is a novel natural inhibitor of human Cathepsin B(CatB), which has antifungal , antioxidant, antiviral, antidiabetic, and neuroprotective activities, it stimulates apoptosis in HSFBs and inhibits angiogenesis of endothelial cells, it is a promising molecule that can be used in hypertrophic scar treatment. Amentoflavone regulated β-catenin and caspase-3 expressions, and inhibited NF-κB signal transduction pathways.
    Targets: NO | TNF-α | NOS | COX | NF-kB | Akt | mTOR | JNK | Caspase | VEGFR | IL Receptor
    In vitro:
    Phytother Res. 2013 May;27(5):713-20.
    Fatty acid synthase inhibition by amentoflavone suppresses HER2/neu (erbB2) oncogene in SKBR3 human breast cancer cells.[Pubmed: 22767439 ]
    Fatty acid synthase (FASN) is a potential therapeutic target for treatment of cancer and obesity, and is highly elevated in 30% of HER2-overexpressing breast cancers. Considerable interest has developed in searching for novel FASN inhibitors as therapeutic agents in treatment of HER2-overexpressing breast cancers.
    METHODS AND RESULTS:
    Amentoflavone was found to be effective in suppressing FASN expression in HER2-positive SKBR3 cells. Pharmacological inhibition of FASN by amentoflavone specifically down-regulated HER2 protein and mRNA, and caused an up-regulation of PEA3, a transcriptional repressor of HER2. In addition, pharmacological blockade of FASN by amentoflavone preferentially decreased cell viability and induced cell death in SKBR3 cells. Palmitate reduced the cytotoxic effect of amentoflavone, as the percentage of viable cells was increased after the addition of exogenous palmitate. Amentoflavone-induced FASN inhibition inhibited the translocation of SREBP-1 in SKBR3 cells. Amentoflavone inhibited phosphorylation of AKT, mTOR, and JNK. The use of pharmacological inhibitors revealed that the modulation of AKT, mTOR, and JNK phosphorylation required synergistic amentoflavone-induced FASN inhibition and HER2 activation in SKBR3 cells.
    CONCLUSIONS:
    These results suggest that amentoflavone modulated FASN expression by regulation of HER2-pathways, and induced cell death to enhance chemopreventive or chemotherapeutic activity in HER2-positive breast cancers.
    Burns. 2014 Aug;40(5):922-9.
    Amentoflavone inhibits angiogenesis of endothelial cells and stimulates apoptosis in hypertrophic scar fibroblasts.[Pubmed: 24280521]
    Amentoflavone (8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl) chromen-4-one; AF) is a biflavonoid derived from the extracts of Selaginella tamariscina. It has been shown that AF has diverse biological effects such as antitumour, etc. It is well known that high cell proliferation, viability, angiogenesis and low apoptosis are key factors in hypertrophic scar formation.
    METHODS AND RESULTS:
    In this study, we report that AF inhibited viability and stimulated apoptosis in hypertrophic scar fibroblasts (HSFBs). Incubation of HSFBs with AF showed its inhibitory effect on cell viability and the exhibition of a series of cellular changes that were consistent with apoptosis. By Western-blot analysis, our data indicated significant increases in the amounts of cleaved caspases 3, 8, 9 and Bax, several apoptotic promoters and a significant decrease in translationally controlled tumour protein (TCTP), an apoptotic inhibitor, in HSFBs treated with AF. Furthermore, AF showed significant inhibitions on the viability, migration and tube formation of endothelial cells, which are associated with angiogenesis. In conclusion, this study suggests that AF stimulates apoptosis in HSFBs and inhibits angiogenesis of endothelial cells.
    CONCLUSIONS:
    Therefore, AF is a promising molecule that can be used in hypertrophic scar treatment.
    Arch Pharm Res. 2006 Sep;29(9):746-51.
    Antifungal effect of amentoflavone derived from Selaginella tamariscina.[Pubmed: 17024847]
    Amentoflavone is a plant bif avonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure.
    METHODS AND RESULTS:
    Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis.
    CONCLUSIONS:
    In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.
    In vivo:
    Int Immunopharmacol. 2013 Nov;17(3):907-16.
    Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis.[Pubmed: 24126114]
    Ulcerative colitis is a chronic inflammatory disorder characterized by oxidative stress, leucocyte infiltration and upregulation of pro-inflammatory cytokines.
    METHODS AND RESULTS:
    The aim of the present study was to examine the effect of amentoflavone on a murine model of ulcerative colitis (UC). UC was induced by intracolonic injection of 3% acetic acid in male Wistar rats. amentoflavone (10 mg/kg·b.wt) or reference drug sulfasalazine (100 mg/kg·b.wt) was administrated intra-peritoneally for 5 consecutive days before induction of colitis with acetic acid. Administration of amentoflavone was found to reduce the extent of inflammatory colonic injury. This was manifested by a decrease in the score of mucosal injury, by lowered colonic wet weight as well as vascular permeability and diminished lactate dehydrogenase (LDH) and myeloperoxidase (MPO) activity reflecting reduced leukocyte infiltration. Furthermore, the mucosal content of lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD), nitric oxide (NO) activity confirms that amentoflavone could significantly inhibit colitis. The treatment also reduced significantly the colonic tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and IL-6 levels as well as the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) compared to colitis control group. The histopathological studies also confirm the foregoing findings. amentoflavone was also able to inhibit the activation and translocation of transcription factors, nuclear factor (NF)-κB subunits (p65/p50).
    CONCLUSIONS:
    These results suggest that amentoflavone exhibits protective effect in acetic acid-induced ulcerative colitis which might be due to its modulation of oxidant/anti-oxidant balance, down-regulation of productions and expressions of pro-inflammatory cytokines, inflammatory mediators and inhibition of NF-κB signal transduction pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8571 mL 9.2857 mL 18.5715 mL 37.143 mL 46.4287 mL
    5 mM 0.3714 mL 1.8571 mL 3.7143 mL 7.4286 mL 9.2857 mL
    10 mM 0.1857 mL 0.9286 mL 1.8571 mL 3.7143 mL 4.6429 mL
    50 mM 0.0371 mL 0.1857 mL 0.3714 mL 0.7429 mL 0.9286 mL
    100 mM 0.0186 mL 0.0929 mL 0.1857 mL 0.3714 mL 0.4643 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服:1413575084
    金松双黄酮; Sciadopitysin CFN98847 521-34-6 C33H24O10 = 580.6 20mg QQ客服:3257982914
    7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin CFN96118 3778-25-4 C34H26O10 = 594.6 5mg QQ客服:215959384
    台湾高黄酮 A; Taiwanhomoflavone A CFN96541 265120-00-1 C33H24O10 = 580.55 5mg QQ客服:215959384
    3,8''-联芹菜甙元; 3,8'-Biapigenin CFN99025 101140-06-1 C30H18O10 = 538.5 5mg QQ客服:2159513211
    GB 1a; GB 1a CFN96934 220611-41-6 C30H22O10 = 542.49 5mg QQ客服:3257982914
    GB 1b; GB 1b CFN89091 19360-72-6 C30H22O10 = 542.49 5mg QQ客服:2159513211
    GB 2a; GB 2a CFN89133 18412-96-9 C30H22O11 = 558.49 5mg QQ客服:1148253675
    荛花醇A; Wikstrol A CFN92960 159736-35-3 C30H22O10 = 542.49 5mg QQ客服:2932563308
    柏木双黄酮; Cupressuflavone CFN70356 3952-18-9 C30H18O10 = 538.5 5mg QQ客服:2159513211

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