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  • 瑞香素-7-甲醚

    Daphnetin 7-methyl ether

    瑞香素-7-甲醚
    产品编号 CFN90593
    CAS编号 19492-03-6
    分子式 = 分子量 C10H8O4 = 192.17
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Coumarins
    植物来源 The roots of Wikstroemia indica (Linn.) C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    瑞香素-7-甲醚 CFN90593 19492-03-6 10mg QQ客服:2159513211
    瑞香素-7-甲醚 CFN90593 19492-03-6 20mg QQ客服:2159513211
    瑞香素-7-甲醚 CFN90593 19492-03-6 50mg QQ客服:2159513211
    瑞香素-7-甲醚 CFN90593 19492-03-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Scientific World Journal.2014, 2014:654193
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  • Exp Ther Med.2019, 18(6):4388-4396
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  • Molecules.2019, 24(10):E1926
  • Anal Biochem.2019, 569:10-15
  • Nutrients2020, 12(2):488
  • ...
  • 生物活性
    Description: Daphnetin 7-methyl ether has anti-inflammatory activity.
    Targets: Immunology & Inflammation related
    In vitro:
    Article first published online: 17 JUN 2015
    In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis[Reference: WebLink]
    The C-8 phenol group is essential to exert the bioactivities of daphnetin, but it is readily conjugated with glucuronic acid prior to excretion.
    METHODS AND RESULTS:
    In this study, Daphnetin 7-methyl ether (7M-DNP) was used to investigate the effect of 7-methyl substitution on daphnetin glucuronidation in human/rat liver (HLM/RLM) and intestine (HIM/RIM) microsomes, and recombinant UDP-glucuronosyltransferases (UGTs). Compared with daphnetin, the Vmax/Km values of 7M-DNP via 8-O-glucuronidation were 2.1-fold lower in HLM, 1.7-fold lower in HIM, and 2.4-fold lower in RLM, suggesting an improvement in metabolic stability. Different from daphnetin 8-O-glucuronidation exclusively catalyzed by UGT1A6 and UGT1A9, UGT1A1, -1A3, -1A7, -1A8, and -1A9 showed glucuronidation activity toward Daphnetin 7-methyl ether . Kinetics studies, chemical inhibition, and the relative activity factor approach were used to demonstrate that UGT1A9 was mainly responsible for the reaction in HLM, whereas UGT1A1 was a primary contributor in HIM. The Vmax/Km values of Daphnetin 7-methyl ether glucuronidation in HLM and HIM were 0.61–0.74-fold lower than those of rat, suggesting the differences between the two species.
    CONCLUSIONS:
    The bioactivity analysis demonstrated that Daphnetin 7-methyl ether had an anti-inflammatory activity comparable to that of daphnetin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.2037 mL 26.0186 mL 52.0373 mL 104.0745 mL 130.0931 mL
    5 mM 1.0407 mL 5.2037 mL 10.4075 mL 20.8149 mL 26.0186 mL
    10 mM 0.5204 mL 2.6019 mL 5.2037 mL 10.4075 mL 13.0093 mL
    50 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.0815 mL 2.6019 mL
    100 mM 0.052 mL 0.2602 mL 0.5204 mL 1.0407 mL 1.3009 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    瑞香苷; Daphnin CFN80132 486-55-5 C15H16O9 = 340.3 5mg QQ客服:1148253675
    瑞香素-7-甲醚; Daphnetin 7-methyl ether CFN90593 19492-03-6 C10H8O4 = 192.17 20mg QQ客服:2159513211
    7-羟基-8-甲氧基香豆素; Hydrangetin CFN89148 485-90-5 C10H8O4 = 192.17 5mg QQ客服:3257982914
    瑞香素二甲醚; Daphnetin dimethyl ether CFN90594 2445-80-9 C11H10O4 = 206.19 10mg QQ客服:2159513211
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服:2932563308
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服:1413575084
    6,7-二羟基香豆素; 6,7-Dihydroxycoumarin CFN99115 305-01-1 C9H6O4 = 178.14 20mg QQ客服:1148253675
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服:215959384
    秦皮甲素; Esculin CFN99114 531-75-9 C15H16O9 = 340.28 20mg QQ客服:2159513211
    异莨菪亭; Isoscopoletin CFN97684 776-86-3 C10H8O4 = 192.17 20mg QQ客服:2159513211

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