箭藿苷A
Sagittatoside A
|
|
产品编号 |
CFN90139 |
| CAS编号 |
118525-35-2 |
| 分子式 = 分子量 |
C33H40O15 = 676.67 |
| 产品纯度 |
>=98% |
| 物理属性 |
Yellow powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The roots of Epimedium brevicornu Maxim |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 箭藿苷A |
CFN90139 |
118525-35-2 |
1mg |
QQ客服：3257982914 |
| 箭藿苷A |
CFN90139 |
118525-35-2 |
5mg |
QQ客服：3257982914 |
| 箭藿苷A |
CFN90139 |
118525-35-2 |
10mg |
QQ客服：3257982914 |
| 箭藿苷A |
CFN90139 |
118525-35-2 |
20mg |
QQ客服：3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
University Medical Center Mainz (Germany)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Kamphaengphet Rajabhat University (Thailand)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
University of Illinois at Chicago (USA)
Heidelberg University (Germany)
National Hellenic Research Foundation (Greece)
Helmholtz Zentrum München (Germany)
University of Canterbury (New Zealand)
The University of Newcastle (Australia)
Chinese University of Hong Kong (China)
Sri Ramachandra University (India)
University of East Anglia (United Kingdom)
Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα, and sagittatoside A and icariin induces ERα phosphorylation at serine 118 residue.
|
| Targets: |
NF-kB | Estrogen receptor | Progestogen receptor |
| In vitro: |
| J Steroid Biochem Mol Biol. 2014 Sep;143:141-51. | | Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERα) and stimulate ER-dependent osteoblastic functions in UMR-106 cells.[Pubmed: 24607839] | Total flavonoids in Herba epimedii (HEP) have been demonstrated to protect against bone loss and bone deterioration associated with estrogen deficiency without exerting any uterotrophic effects. However, it is unclear how flavonoids in HEP exert their protective effects on bone and if different flavonoids exert estrogenic actions in bone cells via similar mechanism of actions.
METHODS AND RESULTS:
The present study aims to investigate the bone anabolic effects of four major flavonoids isolated from HEP, namely icariin, baohuoside-I, epimedin B and sagittatoside A as well as the mechanism involved in mediating their estrogenic actions in rat osteoblastic-like UMR-106 cells. All tested compounds significantly stimulated the cell proliferation rate, alkaline phosphate (ALP) activity and osteoprotegerin (OPG)/receptor activator of nuclear factor κ-B ligand (RANKL) mRNA expression in UMR-106 cells and their effects could be abolished by co-incubation with 10(-6)M ICI 182,780. None of the flavonoids exhibited binding affinities toward ERα and ERβ. However, sagittatoside A selectively activated estrogen response element (ERE)-luciferase activity via ERα. In addition, icariin and sagittatoside A induced ERα phosphorylation at serine 118 residue.
CONCLUSIONS:
Taken together, our results indicated that all four flavonoids from HEP stimulated ER-dependent osteoblastic functions in UMR-106 cells, but only two of them appeared to exert their actions by ligand-independent activation of ERα. Our study provides evidence to support the hypothesis that the estrogen-like protective effects on bone by flavonoids are mediated via mechanisms that are distinct from the classical actions of estrogen. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.4778 mL |
7.3891 mL |
14.7783 mL |
29.5565 mL |
36.9456 mL |
| 5 mM |
0.2956 mL |
1.4778 mL |
2.9557 mL |
5.9113 mL |
7.3891 mL |
| 10 mM |
0.1478 mL |
0.7389 mL |
1.4778 mL |
2.9557 mL |
3.6946 mL |
| 50 mM |
0.0296 mL |
0.1478 mL |
0.2956 mL |
0.5911 mL |
0.7389 mL |
| 100 mM |
0.0148 mL |
0.0739 mL |
0.1478 mL |
0.2956 mL |
0.3695 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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