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    箭藿苷A

    Sagittatoside A

    箭藿苷A
    产品编号 CFN90139
    CAS编号 118525-35-2
    分子式 = 分子量 C33H40O15 = 676.67
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Epimedium brevicornu Maxim
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    箭藿苷A CFN90139 118525-35-2 1mg QQ客服:2932563308
    箭藿苷A CFN90139 118525-35-2 5mg QQ客服:2932563308
    箭藿苷A CFN90139 118525-35-2 10mg QQ客服:2932563308
    箭藿苷A CFN90139 118525-35-2 20mg QQ客服:2932563308
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    IF=12.804(2019)

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  • Evid Based Complement Alternat Med.2016, 2016:1739760
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  • ...
  • 生物活性
    Description: Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα, and sagittatoside A and icariin induces ERα phosphorylation at serine 118 residue.
    Targets: NF-kB | Estrogen receptor | Progestogen receptor
    In vitro:
    J Steroid Biochem Mol Biol. 2014 Sep;143:141-51.
    Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERα) and stimulate ER-dependent osteoblastic functions in UMR-106 cells.[Pubmed: 24607839]
    Total flavonoids in Herba epimedii (HEP) have been demonstrated to protect against bone loss and bone deterioration associated with estrogen deficiency without exerting any uterotrophic effects. However, it is unclear how flavonoids in HEP exert their protective effects on bone and if different flavonoids exert estrogenic actions in bone cells via similar mechanism of actions.
    METHODS AND RESULTS:
    The present study aims to investigate the bone anabolic effects of four major flavonoids isolated from HEP, namely icariin, baohuoside-I, epimedin B and sagittatoside A as well as the mechanism involved in mediating their estrogenic actions in rat osteoblastic-like UMR-106 cells. All tested compounds significantly stimulated the cell proliferation rate, alkaline phosphate (ALP) activity and osteoprotegerin (OPG)/receptor activator of nuclear factor κ-B ligand (RANKL) mRNA expression in UMR-106 cells and their effects could be abolished by co-incubation with 10(-6)M ICI 182,780. None of the flavonoids exhibited binding affinities toward ERα and ERβ. However, sagittatoside A selectively activated estrogen response element (ERE)-luciferase activity via ERα. In addition, icariin and sagittatoside A induced ERα phosphorylation at serine 118 residue.
    CONCLUSIONS:
    Taken together, our results indicated that all four flavonoids from HEP stimulated ER-dependent osteoblastic functions in UMR-106 cells, but only two of them appeared to exert their actions by ligand-independent activation of ERα. Our study provides evidence to support the hypothesis that the estrogen-like protective effects on bone by flavonoids are mediated via mechanisms that are distinct from the classical actions of estrogen.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4778 mL 7.3891 mL 14.7783 mL 29.5565 mL 36.9456 mL
    5 mM 0.2956 mL 1.4778 mL 2.9557 mL 5.9113 mL 7.3891 mL
    10 mM 0.1478 mL 0.7389 mL 1.4778 mL 2.9557 mL 3.6946 mL
    50 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.5911 mL 0.7389 mL
    100 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.2956 mL 0.3695 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    朝藿苷E; Caohuoside E CFN95016 174286-23-8 C43H54O22 = 922.9 5mg QQ客服:2932563308
    朝藿定K; Epimedin K CFN95019 174286-13-6 C45H56O23 = 964.9 5mg QQ客服:3257982914
    淫羊藿次苷; Icariside I CFN92550 56725-99-6 C27H30O11 = 530.5 20mg QQ客服:2056216494
    茂藿苷A; Maohuoside A CFN98523 128988-55-6 C27H32O12 = 548.5 5mg QQ客服:3257982914
    大花淫羊藿苷F; Ikarisoside F CFN90138 113558-14-8 C31H36O14 = 632.62 5mg QQ客服:1413575084
    淫羊藿属苷A; Epimedoside A CFN90762 39012-04-9 C32H38O15 = 662.7 10mg QQ客服:2159513211
    宝藿苷V; Baohuoside V CFN90763 118544-18-6 C38H48O19 = 808.8 10mg QQ客服:2159513211
    宝藿苷I; Baohuoside I CFN98525 113558-15-9 C27H30O10 = 514.52 20mg QQ客服:3257982914
    箭藿苷B; Sagittatoside B CFN90211 118525-36-3 C32H38O14 = 646.64 5mg QQ客服:2056216494
    2''-O-鼠李糖基淫羊藿次苷II; 2''-O-Rhamnosylicariside II CFN92551 135293-13-9 C33H40O14 = 660.7 10mg QQ客服:3257982914

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