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    大花淫羊藿苷F

    Ikarisoside F

    大花淫羊藿苷F
    产品编号 CFN90138
    CAS编号 113558-14-8
    分子式 = 分子量 C31H36O14 = 632.62
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Epimedium brevicornu Maxim
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大花淫羊藿苷F CFN90138 113558-14-8 1mg QQ客服:215959384
    大花淫羊藿苷F CFN90138 113558-14-8 5mg QQ客服:215959384
    大花淫羊藿苷F CFN90138 113558-14-8 10mg QQ客服:215959384
    大花淫羊藿苷F CFN90138 113558-14-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
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  • Molecules.2016, 21(6)
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  • Biomol Ther (Seoul).2019, 10.4062
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  • Food and Agriculture Org. Of the UN2019, 151-160
  • Molecules.2019, 24(4):E744
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Phytomedicine.2019, 65:153089
  • J Mol Recognit.2020, 33(2):e2819
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.
    In vitro:
    Life Sci. 2005 Nov 26;78(2):180-6.
    Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation.[Pubmed: 16125732]
    In the present paper, the inhibitory effect of Epimedium extract on the activity of S-adenosyl-L-homocysteine (AdoHcy) Hydrolase was studied.
    METHODS AND RESULTS:
    The results showed that Epimedium extract inhibited the activity of recombinant human AdoHcy hydrolase in a dose-dependent manner. This inhibitory effect was also observed in hepatic cell line 7701 and hepatoma HepG2, however, the effect in 7701 cells was more potent than in HepG2 cells. The extract could significantly reduce AdoMet/AdoHcy ratio in 7701 cells in a dose-dependent manner, suggesting reduced biomethylation level in 7701 cells. In contrast, it resulted in elevated AdoMet/AdoHcy ratio in the HepG2 cells. The result of MALDI-MS assay indicated that epimedin A and Ikarisoside F from the extract could bind to AdoHcy hydrolase. The present data suggested that Epimedium extract could inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.
    CONCLUSIONS:
    These results will provide new clues to the mechanisms of Epimedium in curing of cardiovascular disease and regulating tumor cell growth.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5807 mL 7.9036 mL 15.8073 mL 31.6146 mL 39.5182 mL
    5 mM 0.3161 mL 1.5807 mL 3.1615 mL 6.3229 mL 7.9036 mL
    10 mM 0.1581 mL 0.7904 mL 1.5807 mL 3.1615 mL 3.9518 mL
    50 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.6323 mL 0.7904 mL
    100 mM 0.0158 mL 0.079 mL 0.1581 mL 0.3161 mL 0.3952 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    朝藿定K; Epimedin K CFN95019 174286-13-6 C45H56O23 = 964.9 5mg QQ客服:1413575084
    淫羊藿次苷; Icariside I CFN92550 56725-99-6 C27H30O11 = 530.5 20mg QQ客服:1148253675
    茂藿苷A; Maohuoside A CFN98523 128988-55-6 C27H32O12 = 548.5 5mg QQ客服:3257982914
    大花淫羊藿苷F; Ikarisoside F CFN90138 113558-14-8 C31H36O14 = 632.62 5mg QQ客服:3257982914
    淫羊藿属苷A; Epimedoside A CFN90762 39012-04-9 C32H38O15 = 662.7 10mg QQ客服:1413575084
    宝藿苷V; Baohuoside V CFN90763 118544-18-6 C38H48O19 = 808.8 10mg QQ客服:2159513211
    宝藿苷I; Baohuoside I CFN98525 113558-15-9 C27H30O10 = 514.52 20mg QQ客服:2159513211
    箭藿苷B; Sagittatoside B CFN90211 118525-36-3 C32H38O14 = 646.64 5mg QQ客服:1413575084
    2''-O-鼠李糖基淫羊藿次苷II; 2''-O-Rhamnosylicariside II CFN92551 135293-13-9 C33H40O14 = 660.7 10mg QQ客服:1148253675
    Sutchuenmedin A; Sutchuenmedin A CFN96542 1197194-31-2 C33H38O14 = 658.65 5mg QQ客服:1413575084

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