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    朝藿定A

    Epimedin A

    朝藿定A
    产品编号 CFN99939
    CAS编号 110623-72-8
    分子式 = 分子量 C39H50O20 = 838.80
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Epimedium brevicornum Maxim
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    朝藿定A CFN99939 110623-72-8 10mg QQ客服:2932563308
    朝藿定A CFN99939 110623-72-8 20mg QQ客服:2932563308
    朝藿定A CFN99939 110623-72-8 50mg QQ客服:2932563308
    朝藿定A CFN99939 110623-72-8 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

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    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Veracuzana (Mexico)
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  • University of Fribourg (Switzerland)
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  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Wuerzburg (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • Analytical sci. & Tech2016, 186-193
  • Chem Biol Interact.2016, 258:59-68
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 197:157-164
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • LWT-Food Science and Technology2017, 75:488-496
  • J Nat Prod.2017, 80(4):854-863
  • Neuropharmacology.2018, 131:68-82
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Industrial Crops and Products2018, 353-362
  • Cell Biochem Funct.2018, 36(6):303-311
  • Biosci Rep.2018, 38(4)
  • Food and Fermentation Industries2018, 44(371)
  • Phytother Res.2019, 10.1002
  • Front Pharmacol.2019, 10:1226
  • Industrial Crops and Products2019, 140:111612
  • Int J Mol Sci.2019, 20(9):E2244
  • Molecules.2019, 24(10):E1930
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Sci Rep.2019, 9(1):18080
  • Molecules2020, 25(4):892
  • ...
  • 生物活性
    Description: Epimedin A,epimendin B, epimendin C, icariin and baohuoside are flavonoids, main active ingredient in Epimedium, have clear anti-osteoporosis effect, the accumulation of epimedins A, B, C, and icariin in a traditional medicinal plant could be suppressed by light stress.
    In vitro:
    Acta Physiol Plant, 2013, 35(11):3271-5.
    Light stress suppresses the accumulation of epimedins A, B, C, and icariin in Epimedium, a traditional medicinal plant.[Reference: WebLink]
    Epimedium is well-known in China and East Asia due to high content of flavonoid derivatives, including icariin, epimedin A, Epimedin B, and epimedin C, hereafter designated as bioactive components, which have been extensively utilized to cure many diseases. So far, the molecular mechanism of the bioactive components biosynthesis remains unclear.
    METHODS AND RESULTS:
    In the present study, the effect of light stress (24 h illumination) on the accumulation of bioactive components and the expression of flavonoid genes in Epimedium was investigated. Under light stress, the structural genes CHS1, CHI1, F3H, FLS, DFR1, DFR2, and ANS were remarkably up-regulated while CHS2 and F3′H were significantly down-regulated. For transcription factors, the expression of Epimedium MYB7 and TT8 were increased while Epimedium GL3, MYBF, and TTG1 expression were depressed. Additionally, the content of bioactive components was significantly decreased under light stress.
    CONCLUSIONS:
    Our results suggested that the decrease of bioactive compounds may be attributed to transcripts of late genes (DFRs and ANS) increased to a higher level than that of early genes (FLS and CHS1).
    In vivo:
    Yao Xue Xue Bao. 2014 Jun;49(6):932-7.
    [Two-dimensional zebrafish model combined with hyphenated chromatographic techniques for evaluation anti-osteoporosis activity of epimendin A and its metabolite baohuoside I].[Pubmed: 25212043]
    This article firstly established a new efficient method for screening anti-osteoporosis ingredients, which used two-dimensional zebrafish model combined with hyphenated chromatographic techniques to evaluate anti-osteoporosis activities of epimedin A and its metabolite baohuoside I.
    METHODS AND RESULTS:
    Adult zebrafish was used for metabolism of epimedin A in 0.5% DMSO, and LC-MS was used for analysis of the metabolite, which was captured by HPLC, and prednisolone-induced osteoporosis model of zebrafish was used to evaluate the anti-osteoporotic activities of trace amounts of epimedin A and baohuoside I. The results indicated that epimedin A and baohuoside I can prevent prednisolone-induced osteoporosis in zebrafish. The developed method in this paper enables the separation, enrichment and analysis of micro-amount metabolite of epimedin A, and anti-osteoporosis activities in vivo of epimedin A and baohuoside I was simple and efficient screening resorting to zebrafish osteoporosis mode.
    CONCLUSIONS:
    This paper would provide new ideas and methods for a rapid and early discovery of anti-osteoporosis activities of micro-ingredients and its metabolite of traditional Chinese medicine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1922 mL 5.9609 mL 11.9218 mL 23.8436 mL 29.8045 mL
    5 mM 0.2384 mL 1.1922 mL 2.3844 mL 4.7687 mL 5.9609 mL
    10 mM 0.1192 mL 0.5961 mL 1.1922 mL 2.3844 mL 2.9804 mL
    50 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.4769 mL 0.5961 mL
    100 mM 0.0119 mL 0.0596 mL 0.1192 mL 0.2384 mL 0.298 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大花淫羊藿苷F; Ikarisoside F CFN90138 113558-14-8 C31H36O14 = 632.62 5mg QQ客服:2159513211
    淫羊藿属苷A; Epimedoside A CFN90762 39012-04-9 C32H38O15 = 662.7 10mg QQ客服:3257982914
    宝藿苷V; Baohuoside V CFN90763 118544-18-6 C38H48O19 = 808.8 10mg QQ客服:3257982914
    宝藿苷I; Baohuoside I CFN98525 113558-15-9 C27H30O10 = 514.52 20mg QQ客服:215959384
    箭藿苷B; Sagittatoside B CFN90211 118525-36-3 C32H38O14 = 646.64 5mg QQ客服:1413575084
    2''-O-鼠李糖基淫羊藿次苷II; 2''-O-Rhamnosylicariside II CFN92551 135293-13-9 C33H40O14 = 660.7 10mg QQ客服:2159513211
    Sutchuenmedin A; Sutchuenmedin A CFN96542 1197194-31-2 C33H38O14 = 658.65 5mg QQ客服:3257982914
    箭藿苷A; Sagittatoside A CFN90139 118525-35-2 C33H40O15 = 676.67 5mg QQ客服:1148253675
    箭藿苷C; Sagittatoside C CFN92077 118525-37-4 C35H42O16 = 718.7 5mg QQ客服:2932563308
    异箭藿苷A; Iso-sagittatoside A CFN91155 503456-08-4 C33H40O15 = 676.7 5mg QQ客服:1148253675

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