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  • Rubrisandrin A

    Rubrisandrin A

    Rubrisandrin A
    产品编号 CFN92278
    CAS编号 919289-30-8
    分子式 = 分子量 C22H28O6 = 388.5
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Lignans
    植物来源 The herbs of Kadsura longipedunculata Finet.et Gagnep
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Rubrisandrin A CFN92278 919289-30-8 1mg QQ客服:2159513211
    Rubrisandrin A CFN92278 919289-30-8 5mg QQ客服:2159513211
    Rubrisandrin A CFN92278 919289-30-8 10mg QQ客服:2159513211
    Rubrisandrin A CFN92278 919289-30-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
  • Medizinische Universit?t Wien (Austria)
  • University of Sao Paulo (Brazil)
  • Worcester Polytechnic Institute (USA)
  • Universidad de Antioquia (Colombia)
  • University of Vigo (Spain)
  • Semmelweis Unicersity (Hungary)
  • Indian Institute of Science (India)
  • Kyushu University (Japan)
  • Lund University (Sweden)
  • University of East Anglia (United Kingdom)
  • Stanford University (USA)
  • University of Perugia (Italy)
  • St. Jude Children Research Hospital (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Mol Med Rep.2014, 9(5):1653-9
  • Phytomedicine.2015, 22(11):1027-36
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • J Pharm Biomed Anal2016, 118:183-194
  • Phytother Res.2016, 30(12):2020-2026
  • Molecules.2017, 22(2)
  • Oncotarget.2017, 9(3):4161-4172
  • Lab Chip.2018, 18(6):971-978
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Exp Neurobiol.2018, 27(3):200-209
  • Front Cell Infect Microbiol.2018, 8:292
  • Nat Commun.2019, 10(1):5169
  • Journal of Ginseng Research2019, 10.1016
  • Front Pharmacol.2019, 10:1226
  • Nutrients.2019, 11(6):E1380
  • Industrial Crops and Products2019, 140:111612
  • Neuropharmacology2019, 151437
  • Exp Ther Med.2019, 18(6):4388-4396
  • BMC Complement Altern Med.2019, 19(1):367
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Food and Chemical Toxicology2020, 111221
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Rubrisandrin A is an anti-HIV agent.
    Targets: HIV
    In vitro:
    J Nat Prod. 2006 Dec;69(12):1697-701.
    Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.[Pubmed: 17190445 ]

    METHODS AND RESULTS:
    Bioactivity-directed fractionation of an ethanolic extract of the fruits of Schisandra rubriflora led to the isolation and identification of dibenzocyclooctadiene lignans including the new lignans Rubrisandrin A (1a + 1b) and B (2) and the known lignans gomisin J (3), (+/-)-gomisin M1 (4), (+)-gomisin M2 (5), schisanhenol (6), deoxyschisandrin, schisantherin B, schisandrin, tigloylgomisin P, gomisin O, angeloylgomisin P, and epigomisin O. Their structure and stereochemistry were determined by spectroscopic methods, including 2D-NMR techniques.
    CONCLUSIONS:
    Compounds 1 and 3-6 were active as anti-HIV agents. (+/-)-Gomisin M1 (4) exhibited the most potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.
    Planta Med. 2010 Oct;76(15):1672-7.
    Evaluation of cytotoxic activity of Schisandra chinensis lignans.[Pubmed: 20458670 ]

    METHODS AND RESULTS:
    Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, Rubrisandrin A, (-)-gomisin G, (+)-gomisin K (3) and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, (1)H- and (13)C-NMR and MS.
    CONCLUSIONS:
    The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.574 mL 12.87 mL 25.74 mL 51.4801 mL 64.3501 mL
    5 mM 0.5148 mL 2.574 mL 5.148 mL 10.296 mL 12.87 mL
    10 mM 0.2574 mL 1.287 mL 2.574 mL 5.148 mL 6.435 mL
    50 mM 0.0515 mL 0.2574 mL 0.5148 mL 1.0296 mL 1.287 mL
    100 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.5148 mL 0.6435 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    戈米辛N; Gomisin N CFN90125 69176-52-9 C23H28O6 = 400.46 20mg QQ客服:2159513211
    五味子乙素; Schizandrin B CFN99923 61281-37-6 C23H28O6 = 400.47 20mg QQ客服:1148253675
    戈米辛A; Gomisin A CFN98990 58546-54-6 C23H28O7 = 416.5 20mg QQ客服:1413575084
    R(+)-戈米辛M1; R(+)-Gomisin M1 CFN97309 82467-50-3 C22H26O6 = 386.4 5mg QQ客服:2159513211
    五味子酚; Schisanhenol CFN90364 69363-14-0 C23H30O6 = 402.48 20mg QQ客服:2159513211
    戈米辛 K1; Gomisin K1 CFN96724 75629-20-8 C23H30O6 = 402.48 5mg QQ客服:1148253675
    戈米辛M2; Gomisin M2 CFN97306 82425-45-4 C22H26O6 = 386.4 5mg QQ客服:215959384
    戈米辛 L1; Gomisin L1 CFN96734 82425-43-2 C22H26O6 = 386.44 5mg QQ客服:215959384
    戈米辛 L2; Gomisin L2 CFN96726 82425-44-3 C22H26O6 = 386.44 5mg QQ客服:1148253675
    异南五味子木脂宁; Isokadsuranin CFN90912 82467-52-5 C23H28O6 = 400.46 5mg QQ客服:2932563308

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