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  • 五味子甲素

    Schizandrin A

    五味子甲素
    产品编号 CFN99922
    CAS编号 61281-38-7
    分子式 = 分子量 C24H32O6 = 416.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The seeds of Schisandra chinensis (Turcz.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子甲素 CFN99922 61281-38-7 10mg QQ客服:3257982914
    五味子甲素 CFN99922 61281-38-7 20mg QQ客服:3257982914
    五味子甲素 CFN99922 61281-38-7 50mg QQ客服:3257982914
    五味子甲素 CFN99922 61281-38-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Research Council of Canada (Canada)
  • National Cancer Center Research Institute (Japan)
  • Sri Ramachandra University (India)
  • Universidad de Buenos Aires (Argentina)
  • MTT Agrifood Research Finland (Finland)
  • University of Padjajaran (Indonesia)
  • Shanghai University of TCM (China)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Stirling (United Kingdom)
  • Griffith University (Australia)
  • Helmholtz Zentrum München (Germany)
  • Univerzita Karlova v Praze (Czech Republic)
  • Istanbul University (Turkey)
  • Universidade de Franca (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Phytomedicine.2015, 22(4):498-503
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Sci Rep.2015, 5:13194
  • Oncotarget.2015, 6(31):30831-49
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • J Ethnopharmacol.2017, 198:205-213
  • Srinagarind Medical Journal2017, 32(1)
  • J Agric Food Chem.2017, 65(13):2670-2676
  • Oncotarget.2017, 8(53):90925-90947
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Toxicol In Vitro.2018, 52:94-105
  • Biochemistry.2018, 57(40):5886-5896
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Nutrients.2019, 12(1):E40
  • Front Neurosci.2019, 13:1091
  • J of Physics Conference Series2019, 1349(1)
  • BMC Complement Altern Med.2019, 19(1):367
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2019, 24(11):E2044
  • Molecules.2019, 24(16):E2985
  • Environ Toxicol.2019, 34(12):1354-1362
  • Antioxidants (Basel).2020, 9(2):E120
  • ...
  • 生物活性
    Description: Schisandrin A , an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM, has neuroprotective, anti-inflammatory, liver-protective, antitumor, and antioxidant activities. It alleviated microglia-mediated neuroinflammation injury through inhibiting the TRAF6-IKKβ-NF-κB and Jak2-Stat3 signaling pathways. It inhibited CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively.
    Targets: ERK | JNK | p38MAPK | Caspase | NO | TNF-α | IL Receptor | NOS | COX | JAK | STAT | NF-kB | IkB | P-gp | P450 (e.g. CYP17) | IKK
    In vitro:
    J Physiol Biochem. 2014 Sep;70(3):735-47.
    Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.[Pubmed: 24986222]
    Brain ischemia appears to be associated with innate immunity. Recent reports showed that C3a and C5a, as potent targets, might protect against ischemia induced cell death. In traditional Chinese medicine, the fruit of Schizandra chinesis Baill (Fructus schizandrae) has been widely used as a tonic.
    METHODS AND RESULTS:
    In the present study, we sought to evaluate the neuroprotective effects of schizandrin A, a composition of S. chinesis Baill, against oxygen and glucose deprivation followed by reperfusion (OGD/R)-induced cell death in primary culture of rat cortical neurons, and to test whether C3a and C5a affected cortical neuron recovery from ischemic injury after schizandrin A treatment. The results showed that schizandrin A significantly reduced cell apoptosis and necrosis, increased cell survival, and decreased intracellular calcium concentration ([Ca(2+)]i) and lactate dehydrogenase (LDH) release in primary culture of rat cortical neurons after OGD/R. Mechanism studies suggested that the modulation of extracellular-regulated kinase (ERK), c-Jun NH2-terminal kinases (JNK), and p38, as well as caspase-3 activity played an important role on the progress of neuronal apoptosis. C5aR participated in the neuroprotective effect of schizandrin A in primary culture of rat cortical neurons after OGD/R.
    CONCLUSIONS:
    Our findings suggested that schizandrin A might act as a candidate therapeutic target drug used for brain ischemia and related diseases.
    Chinese Pharmacological Bulletin, 2011, 27(3): 329-34.
    Reversing mechanism of schizandrin A on multi-drug resistance of K562/ADR,HL60/ADR,MCF-7/ADR cell lines.[Reference: WebLink]
    To study the reversal effect of Schizandrin A(schA) on the K562/ADR,HL60/ADR,MCF-7/ADR,and explore its reversal mechanism.
    METHODS AND RESULTS:
    schA′s reversal effect was evaluated by MTT assay;accumulation of daunorubicin(DNR)and rhodamine-123(Rh123)and the expression of P-glycoprotein and multidrug resistance associated protein 1(MRP1)were evaluated by flow cytometry(FCM);the expression of intracellular mdr1 mRNA and mrp1 mRNA was detected with Real-time PCR;the changes of GSH content were detected by biochemical tests.Results The result of reversion of multidrug resistance showed schA had different reversal effects on different mechanisms of chemotherapeutic agents;the experiments of accumulation showed that the schA could significantly increase daunorubicin,rhodamine 123 contents in resistant cells,which had a good dose dependent effect;the treatment of schA could reduce remarkably the expressions of the P-gp protein and mdr1,mrp1 gene after 24 h treatment;and it could reduce GSH content after 4 h treatment in K562/ADR,HL60/ADR.
    CONCLUSIONS:
    schA has the reversal effect of drug resistance in different mechanisms of the two cell lines of K562/ADR and HL60/ADR.It increases the concentration of the drug resistant cells mainly by inhibiting the function and expression of P-gp,MRP1 protein and reducing mdr1,mrp1 gene expression and GSH content,and then it enhances the sensitivity and reversal effects of resistant cell lines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4009 mL 12.0045 mL 24.009 mL 48.0181 mL 60.0226 mL
    5 mM 0.4802 mL 2.4009 mL 4.8018 mL 9.6036 mL 12.0045 mL
    10 mM 0.2401 mL 1.2005 mL 2.4009 mL 4.8018 mL 6.0023 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
    100 mM 0.024 mL 0.12 mL 0.2401 mL 0.4802 mL 0.6002 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    戈米辛N; Gomisin N CFN90125 69176-52-9 C23H28O6 = 400.46 20mg QQ客服:2932563308
    五味子乙素; Schizandrin B CFN99923 61281-37-6 C23H28O6 = 400.47 20mg QQ客服:3257982914
    戈米辛A; Gomisin A CFN98990 58546-54-6 C23H28O7 = 416.5 20mg QQ客服:2932563308
    R(+)-戈米辛M1; R(+)-Gomisin M1 CFN97309 82467-50-3 C22H26O6 = 386.4 5mg QQ客服:2159513211
    五味子酚; Schisanhenol CFN90364 69363-14-0 C23H30O6 = 402.48 20mg QQ客服:3257982914
    戈米辛 K1; Gomisin K1 CFN96724 75629-20-8 C23H30O6 = 402.48 5mg QQ客服:2159513211
    戈米辛M2; Gomisin M2 CFN97306 82425-45-4 C22H26O6 = 386.4 5mg QQ客服:3257982914
    戈米辛 L1; Gomisin L1 CFN96734 82425-43-2 C22H26O6 = 386.44 5mg QQ客服:1148253675
    戈米辛 L2; Gomisin L2 CFN96726 82425-44-3 C22H26O6 = 386.44 5mg QQ客服:1148253675
    异南五味子木脂宁; Isokadsuranin CFN90912 82467-52-5 C23H28O6 = 400.46 5mg QQ客服:215959384

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