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  • 五味子丙素

    Schizandrin C

    五味子丙素
    产品编号 CFN99708
    CAS编号 61301-33-5
    分子式 = 分子量 C22H24O6 = 384.42
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The seeds of Schisandra chinensis (Turcz.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子丙素 CFN99708 61301-33-5 10mg QQ客服:1148253675
    五味子丙素 CFN99708 61301-33-5 20mg QQ客服:1148253675
    五味子丙素 CFN99708 61301-33-5 50mg QQ客服:1148253675
    五味子丙素 CFN99708 61301-33-5 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Pennsylvania State University (USA)
  • Cornell University (USA)
  • University of Toronto (Canada)
  • Universidad de Buenos Aires (Argentina)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Vigo (Spain)
  • Amity University (India)
  • Monash University Malaysia (Malaysia)
  • Harvard University (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • University of British Columbia (Canada)
  • Charles University in Prague (Czech Republic)
  • Gyeongsang National University (Korea)
  • University of Amsterdam (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • Am J Chin Med.2015, 30:1-22
  • SBRAS2016, 12
  • Biochem Systematics and Ecology2017, 11-18
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Biochem Pharmacol.2017, 130:10-20
  • Semyung University2017, 149407
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 209:305-316
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Korean J of Medicinal Crop Science2018, 220-226
  • Biosci Rep.2018, 38(4)
  • Academic J of Second Military Medical University2018, 39(11)
  • Phytomedicine.2018, 40:37-47
  • Virulence.2018, 9(1):588-603
  • Front Plant Sci.2018, 9:1424
  • Int J Mol Sci.2019, 20(16):E4015
  • Molecules.2019, 24(7):E1290
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Food Sci Nutr.2019, 8(1):246-256
  • Antioxidants (Basel).2019, 8(8):E307
  • Br J Pharmacol.2020, 10.1111
  • J Ethnopharmacol.2020, 249:112396
  • ...
  • 生物活性
    Description: Schizandrin C isolated from Schisandra chinensis could be used as a natural anti-neuroinflammatory agent, inducing phase II detoxifying/antioxidant enzymes via cAMP/PKA/CREB and Nrf-2 signaling.
    Targets: HO-1 | cAMP | Nrf2 | PKA | NO | NOS | COX | PGE | ROS | MMP(e.g.TIMP) | JAK | STAT | p38MAPK | NF-kB | AP-1 | NQO-1 | CREB
    In vitro:
    Int Immunopharmacol. 2013 Oct;17(2):415-26.
    Schisandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia.[Pubmed: 23859871]
    We investigated the anti-neuroinflammatory properties of schizandrin C by focusing on its roles in the induction of phase II detoxifying/antioxidant enzymes and in the modulation of upstream signaling pathways.
    METHODS AND RESULTS:
    Schizandrin C induced expression of phase II detoxifying/antioxidant enzymes including heme oxygenase-1 (HO-1) and NADPH dehydrogenase quinone-1 (NQO-1). Activation of upstream signaling pathways, such as the cAMP/protein kinase A/cAMP response element-binding protein (cAMP/PKA/CREB) and erythroid-specific nuclear factor-regulated factor 2 (Nrf-2) pathways, significantly increased following treatment with schizandrin C. In addition, expressions of schizandrin C-mediated phase II detoxifying/antioxidant enzymes were completely attenuated by adenylyl cyclase inhibitor (ddAdo) and protein kinase A (PKA) inhibitor (H-89). In microglia, schizandrin C significantly inhibited lipoteichoic acid (LTA)-stimulated pro-inflammatory cytokines and chemokines, prostaglandin E2 (PGE2), nitric oxide (NO), and reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and matrix metallopeptidase-9 (MMP-9) protein expressions. Moreover, schizandrin C suppressed LTA-induced nuclear factor-kappa B (NF-κB), activator protein-1 (AP-1), janus-kinase/signal transducer and activator of transcription (JAK-STATs), and mitogen-activated protein kinase (MAPK) activation. Schizandrin C also effectively suppressed ROS generation and NO production, as well as iNOS promoter activity in LTA-stimulated microglia. This suppressive effect was reversed by transfection with Nrf-2 and HO-1 siRNA and co-treatment with inhibitors ddAdo and H-89.
    CONCLUSIONS:
    Our results indicate that schizandrin C isolated from Schisandra chinensis could be used as a natural anti-neuroinflammatory agent, inducing phase II detoxifying/antioxidant enzymes via cAMP/PKA/CREB and Nrf-2 signaling.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6013 mL 13.0066 mL 26.0132 mL 52.0264 mL 65.033 mL
    5 mM 0.5203 mL 2.6013 mL 5.2026 mL 10.4053 mL 13.0066 mL
    10 mM 0.2601 mL 1.3007 mL 2.6013 mL 5.2026 mL 6.5033 mL
    50 mM 0.052 mL 0.2601 mL 0.5203 mL 1.0405 mL 1.3007 mL
    100 mM 0.026 mL 0.1301 mL 0.2601 mL 0.5203 mL 0.6503 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    戈米辛 L1; Gomisin L1 CFN96734 82425-43-2 C22H26O6 = 386.44 5mg QQ客服:2159513211
    戈米辛 L2; Gomisin L2 CFN96726 82425-44-3 C22H26O6 = 386.44 5mg QQ客服:2932563308
    异南五味子木脂宁; Isokadsuranin CFN90912 82467-52-5 C23H28O6 = 400.46 5mg QQ客服:1148253675
    五脂酮C; Schisanlignone C CFN92723 144606-83-7 C23H26O7 = 414.5 5mg QQ客服:2932563308
    五味子丙素; Schizandrin C CFN99708 61301-33-5 C22H24O6 = 384.42 20mg QQ客服:1148253675
    五脂酮D; Schisanlignone D CFN92724 144606-84-8 C22H22O7 = 398.4 5mg QQ客服:2159513211
    环氧五味子丙素; Schisandrin C epoxide CFN92841 81345-36-0 C22H22O7 = 398.4 5mg QQ客服:2932563308
    Rubrisandrin A; Rubrisandrin A CFN92278 919289-30-8 C22H28O6 = 388.5 5mg QQ客服:1148253675
    五味子甲素; Schizandrin A CFN99922 61281-38-7 C24H32O6 = 416.51 20mg QQ客服:1413575084
    五味子醇甲; Schisandrol A CFN99012 7432-28-2 C24H32O7 = 432.5 20mg QQ客服:2159513211

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