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  • 黄藤素; 巴马汀

    Palmatine

    黄藤素; 巴马汀
    产品编号 CFN98459
    CAS编号 3486-67-7
    分子式 = 分子量 C21H22NO4 = 352.4
    产品纯度 >=98%
    物理属性 Yellow Powder
    化合物类型 Alkaloids
    植物来源 The rhizomes of Coptis chinensis Franch.
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    黄藤素; 巴马汀 CFN98459 3486-67-7 10mg QQ客服:1148253675
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    黄藤素; 巴马汀 CFN98459 3486-67-7 50mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Toulouse (France)
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  • Pennsylvania State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Physiologiae Plantarum2015, 37:1736
  • Arch Pharm Res.2015, 38(6):1080-9
  • J Chromatogr Sci.2015, 53(5):824-9
  • University of Limpopo2016, 1-237
  • Chem Biol Interact.2016, 258:59-68
  • University of Central Lancashire2017, 20472
  • J Ethnopharmacol.2017, 209:305-316
  • Phytomedicine.2017, 24:77-86
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • J Nat Prod.2017, 80(4):854-863
  • Anat Rec2018, 24264
  • International Food Research Journal2018, 25(6):2560-2571
  • Phytomedicine.2018, 38:12-23
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • J Nat Prod.2018, 81(4):966-975
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Molecules.2019, 24(22):E4022
  • Molecules.2019, 24(6):E1177
  • FASEB J.2019, 33(8):9685-9694
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • J Mater Chem B.2019, 7(39):5896-5919
  • ...
  • 生物活性
    Description: Palmatine shows significant antidepressant-like, anti-hyperlipidemia, hepatoprotective, and antioxidant effects, it inhibited MAO-A, I(K) and I(CRAC) activity, and activated the AhR-CYP1A pathway. Palmatine shows the strong toxic action on T. thermophila BF5 growth, it is toxic to insects and vertebrates and inhibited the multiplication of bacteria, fungi and viruses, it is active at the alpha 2-receptor ( IC50 of 956 nM).
    Targets: P450 (e.g. CYP17) | MAO | NF-kB | LDL | DNA/RNA Synthesis | 5-HT Receptor | Adrenergic Receptor | AChR | Antifection | alpha 2-receptor
    In vitro:
    Mol Carcinog. 2015 Oct;54(10):1227-34.
    Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP.[Pubmed: 25043857]
    Novel agents are desperately needed for improving the quality of life and 5-year survival to more than 30% for metastatic castrate-resistant prostate cancer. Previously we showed that Nexrutine, Phellodendron amurense bark extract, inhibits prostate tumor growth in vitro and in vivo. Subsequently using biochemical fractionation we identified butanol fraction contributes to the observed biological activities.
    METHODS AND RESULTS:
    We report here that palmatine, which is present in the butanol fraction, selectively inhibits growth of prostate cancer cells without significant effect on non-tumorigenic prostate epithelial cells. By screening receptor tyrosine kinases in a protein kinase array, we identified ribosomal protein S6, a downstream target of p70S6K and the Akt/mTOR signaling cascade as a potential target. We further show that palmatine treatment is associated with decreased activation of NFκB and its downstream target gene FLIP. These events led to inhibition of invasion. Similar results were obtained using parent extract Nexrutine (Nx) suggesting that palmatine either in the purified form or as one of the components in Nx is a potent cytotoxic agent with tumor invasion inhibitory properties. Synergistic inhibition of rpS6/NFκB/FLIP axis with palmatine may have therapeutic potential for the treatment of prostate cancer and possibly other malignancies with their constitutive activation.
    METHODS AND RESULTS:
    These data support a biological link between rpS6/NFκB/FLIP in mediating palmatine-induced inhibitory effects and warrants additional preclinical studies to test its therapeutic efficacy.
    World J Gastroenterol. 2003 Feb;9(2):329-33.
    Effects of palmatine on potassium and calcium currents in isolated rat hepatocytes.[Pubmed: 12532460]
    To study the effects of palmatine, a known inhibitor on delayed rectifier potassium current and L-type calcium current (I(Ca,L)) in guinea pig ventricular myocytes, on the potassium and calcium currents in isolated rat hepatocytes.
    METHODS AND RESULTS:
    Tight-seal whole-cell patch-clamp techniques were performed to investigate the effects of palmatine on the delayed outward potassium currents (I(K)), inward rectifier potassium current (I(K1)) and Ca(2+) release-activated Ca(2+) current (I(CRAC)) in enzymatically isolated rat hepatocytes. Palmatine 0.3-100 microM reduced I(K) in a concentration-dependent manner with EC(50) of 41.62+/-10.11 microM and n(H), 0.48+/-0.07 (n=8). The effect of the drug was poorly reversible after washout. When the bath solution was changed to tetraethylammonium (TEA) 8 mM, IK was inhibited. Palmatine 10 microM and 100 microM shifted the I-V curves of I(K) downward, and the block of I(K) was voltage-independent. Palmatine 0.3-100 microM also inhibited I(CRAC) in a concentration-dependent manner. The fitting parameters were as follows: EC(50)=51.19+/-15.18 microM, and n(H)=0.46+/-0.07 (n=8). The peak value of I(CRAC) in the I-V relationship was decreased by palmatine 10 microM and 100 microM. But the reverse potential of I(CRAC) occurred at Voltage=0 mV in all cells. Palmatine 0.3-100 microM failed to have any significant effect on either inward or outward components of I(K1) at any membrane potential examined.
    CONCLUSIONS:
    The inhibitory effects on I(K) and I(CRAC) could be one of the mechanisms that palmatine exerts protective effect on hepatocytes.
    In vivo:
    J Hazard Mater. 2009 Sep 15;168(2-3):609-13.
    Action of palmatine on Tetrahymena thermophila BF5 growth investigated by microcalorimetry.[Pubmed: 19286310 ]

    METHODS AND RESULTS:
    Using a thermal activity monitor (TAM) air isothermal microcalorimeter with ampoule mode, the thermo-genic curves of the metabolism of Tetrahymena thermophila BF(5) growth at 28 degrees C were obtained and the action of palmatine on it was investigated. Meanwhile, the biomass change during the process of T. thermophila BF(5) growth coexisted with palmatine was studied by a haemacytometer. The results showed that a low concentration (50 microg/mL) of palmatine began to inhibit the growth of T. thermophila BF(5), and when the concentration of palmatine reached 600 microg/mL, T. thermophila BF(5) could not grow at all. The relationship between the growth rate constant (k) and the concentration c was almost linear with the correlation coefficient of 0.9957, showing the strong toxic action of palmatine on T. thermophila BF(5) growth.
    CONCLUSIONS:
    The biomass during T. thermophila BF(5) growth decreased obviously by the addition of palmatine at different concentrations. The investigation of biomass agreed well with the results obtained by means of microcalorimetry.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8377 mL 14.1884 mL 28.3768 mL 56.7537 mL 70.9421 mL
    5 mM 0.5675 mL 2.8377 mL 5.6754 mL 11.3507 mL 14.1884 mL
    10 mM 0.2838 mL 1.4188 mL 2.8377 mL 5.6754 mL 7.0942 mL
    50 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.1351 mL 1.4188 mL
    100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5675 mL 0.7094 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    非洲防己碱; Columbamine CFN90581 3621-36-1 C20H20NO4 = 338.38 20mg QQ客服:1148253675
    黄藤素; 巴马汀; Palmatine CFN98459 3486-67-7 C21H22NO4 = 352.4 20mg QQ客服:2159513211
    盐酸巴马汀; Palmatine hydrochloride CFN99124 10605-02-4 C21H22ClNO4 = 387.86 20mg QQ客服:2932563308
    1-Methoxyberberine; 1-Methoxyberberine CFN89079 29133-52-6 C21H20NO5 = 352.38 5mg QQ客服:1148253675
    假巴马汀碱; Pseudopalmatine CFN98001 19716-66-6 C21H22NO4 = 352.4 5mg QQ客服:2159513211
    二氢黄藤素; Dihydropalmatine CFN93083 26067-60-7 C21H23NO4 = 353.41 5mg QQ客服:1413575084
    去亚甲基小檗碱; Demethyleneberberine CFN90696 25459-91-0 C19H18NO4 = 324.35 10mg QQ客服:2932563308
    巴马亭红碱; Palmatrubine CFN90505 16176-68-4 C20H20NO4 = 338.38 20mg QQ客服:2159513211
    药根碱; Jatrorrhizine CFN98493 3621-38-3 C20H20NO4 = 338.4 20mg QQ客服:1413575084
    格兰地新; Groenlandicine CFN80375 38691-95-1 C19H16NO4 = 322.10 5mg QQ客服:215959384

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