• 中药标准品生产商,产品定制服务
  • 非洲防己碱

    Columbamine

    非洲防己碱
    产品编号 CFN90581
    CAS编号 3621-36-1
    分子式 = 分子量 C20H20NO4 = 338.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Coptis chinensis Franch
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    非洲防己碱 CFN90581 3621-36-1 10mg QQ客服:1148253675
    非洲防己碱 CFN90581 3621-36-1 20mg QQ客服:1148253675
    非洲防己碱 CFN90581 3621-36-1 50mg QQ客服:1148253675
    非洲防己碱 CFN90581 3621-36-1 100mg QQ客服:1148253675
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Antioquia (Colombia)
  • VIT University (India)
  • Heidelberg University (Germany)
  • University of Melbourne (Australia)
  • Imperial College London (United Kingdom)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Amsterdam (Netherlands)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Cincinnati (USA)
  • Chinese University of Hong Kong (China)
  • Florida International University (USA)
  • Srinakharinwirot University (Thailand)
  • Worcester Polytechnic Institute (USA)
  • University of Toronto (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2013, 24(5):493-503
  • PLoS One.2015, 10(5):e0127060
  • Mol Med Rep.2015, 12(5):7789-95
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Phytother Res.2016, 30(12):2020-2026
  • Acta horticulturae2017, 1158:257-268
  • Research on Crops.2017, 18(2)
  • Pharm Biol.2017, 55(1):360-366
  • Integr Med Res.2017, 6(4):395-403
  • Sci Rep.2017, 7:40345
  • Food Res Int.2017, 96:40-45
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Arch Biochem Biophys.2018, 644:93-99
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Chemistry of Plant Materials.2019, 215-222
  • Life Sci.2019, 216:259-270
  • Nat Prod Sci.2019, 25(3):238
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Planta Med.2019, 85(3):217-224
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. It shows strong acetylcholinesterase (AChE) inhibitory activity with IC50 48.1 µM.
    Targets: AChR | STAT | CDK | MMP(e.g.TIMP)
    In vitro:
    Toxicol Lett. 2012 Dec 17;215(3):174-80.
    Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity.[Pubmed: 23124089]
    Columbamine (COL), an active component of the herb Coptis chinensis, inhibited the proliferation and neovascularization of metastatic osteosarcoma U2OS cells.
    METHODS AND RESULTS:
    Columbamine effectively suppressed U2OS cell proliferation in vitro with an IC(50) of 21.31±0.38μM, with low cytotoxicity. Mechanistic studies revealed that Columbamine induces cell cycle arrest at the G2/M transition, which is associated with attenuating CDK6 gene expression and diminishing STAT3 phosphorylation. Columbamine did not significantly promote U2OS cell apoptosis at any of the dosages tested. Additionally, Columbamine inhibited U2OS cell-mediated neovascularization, which was accompanied by the down-regulation of matrix metalloproteinase (MMP) 2 expression and reduction of cell migration, adhesion, and invasion. Taken together, our data show that Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.
    CONCLUSIONS:
    These results warrant further investigation of Columbamine as a potential anti-osteosarcoma and anti-cancer drug.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9553 mL 14.7763 mL 29.5526 mL 59.1051 mL 73.8814 mL
    5 mM 0.5911 mL 2.9553 mL 5.9105 mL 11.821 mL 14.7763 mL
    10 mM 0.2955 mL 1.4776 mL 2.9553 mL 5.9105 mL 7.3881 mL
    50 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.1821 mL 1.4776 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.5911 mL 0.7388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    盐酸巴马汀; Palmatine hydrochloride CFN99124 10605-02-4 C21H22ClNO4 = 387.86 20mg QQ客服:2932563308
    1-Methoxyberberine; 1-Methoxyberberine CFN89079 29133-52-6 C21H20NO5 = 352.38 5mg QQ客服:2932563308
    假巴马汀碱; Pseudopalmatine CFN98001 19716-66-6 C21H22NO4 = 352.4 5mg QQ客服:3257982914
    二氢黄藤素; Dihydropalmatine CFN93083 26067-60-7 C21H23NO4 = 353.41 5mg QQ客服:1148253675
    去亚甲基小檗碱; Demethyleneberberine CFN90696 25459-91-0 C19H18NO4 = 324.35 10mg QQ客服:2932563308
    巴马亭红碱; Palmatrubine CFN90505 16176-68-4 C20H20NO4 = 338.38 20mg QQ客服:2159513211
    药根碱; Jatrorrhizine CFN98493 3621-38-3 C20H20NO4 = 338.4 20mg QQ客服:2932563308
    格兰地新; Groenlandicine CFN80375 38691-95-1 C19H16NO4 = 322.10 5mg QQ客服:1148253675
    盐酸药根碱; Jatrorrhizine Hydrochloride CFN98108 6681-15-8 C20H20ClNO4 = 373.83 20mg QQ客服:1148253675
    非洲防己碱; Columbamine CFN90581 3621-36-1 C20H20NO4 = 338.38 20mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 215959384
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产