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    反式-橙花叔醇

    Nerolidol

    反式-橙花叔醇
    产品编号 CFN98638
    CAS编号 7212-44-4
    分子式 = 分子量 C15H26O = 222.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The peels of Citrus maxima
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    反式-橙花叔醇 CFN98638 7212-44-4 10mg QQ客服:1457312923
    反式-橙花叔醇 CFN98638 7212-44-4 20mg QQ客服:1457312923
    反式-橙花叔醇 CFN98638 7212-44-4 50mg QQ客服:1457312923
    反式-橙花叔醇 CFN98638 7212-44-4 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mendel University in Brno (Czech Republic)
  • Max Rubner-Institut (MRI) (Germany)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Zurich (Switzerland)
  • Chinese University of Hong Kong (China)
  • Celltrion Chemical Research Institute (Korea)
  • Univerzita Karlova v Praze (Czech Republic)
  • Sapienza University of Rome (Italy)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Oslo (Norway)
  • Medizinische Universit?t Wien (Austria)
  • University of Helsinki (Finland)
  • University of British Columbia (Canada)
  • National Chung Hsing University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • J Ethnopharmacol.2016, 192:370-381
  • J Pharm Biomed Anal.2017, 140:274-280
  • J Ethnopharmacol.2017, 198:205-213
  • J Ethnopharmacol.2017, 209:305-316
  • J Food Compos Anal2017, 62:197-204
  • Front Pharmacol.2017, 8:205
  • Int J Mol Sci.2018, 19(2)
  • European Journal of Integrative Medicine2018, 20:165-172
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Biol Pharm Bull.2018, 41(1):65-72
  • J Nat Prod.2018, 81(4):966-975
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • The Korea Journal of Herbology2019, 34(2):25-32
  • J Mol Histol.2019, 50(4):343-354
  • Neurochem Int.2020, 133:104629
  • Journal of Chromatography A2020, 460942
  • Dent Mater J.2020, 39(4):690-695
  • Drug Chem Toxicol.2020, 1-14.
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Antioxidants (Basel).2020, 9(4):326.
  • Phytomedicine.2021, 2(82):153452
  • Food Research2021, 5(1):65-71
  • ...
  • 生物活性
    Description: Nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs. Nerolidol shows anti-cancer, sedative, antiulcer, antifungal, and antifeeding effects. Nerolidol can inhibit the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 uM, respectively.
    Targets: Antifection | ROS
    In vitro:
    Appl Microbiol Biotechnol. 2014 Nov;98(22):9447-57.
    Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus.[Pubmed: 25027570]
    The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance. Staphylococcus aureus is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm formation of S. aureus is one of the mechanisms of its drug resistance.
    METHODS AND RESULTS:
    In this study, anti-biofilm screening of 83 essential oils showed that black pepper, cananga, and myrrh oils and their common constituent cis-nerolidol at 0.01 % markedly inhibited S. aureus biofilm formation. Furthermore, the three essential oils and cis-nerolidol at below 0.005 % almost abolished the hemolytic activity of S. aureus. Transcriptional analyses showed that black pepper oil down-regulated the expressions of the α-toxin gene (hla), the nuclease genes, and the regulatory genes. In addition, black pepper, cananga, and myrrh oils and cis-nerolidol attenuated S. aureus virulence in the nematode Caenorhabditis elegans. This study is one of the most extensive on anti-virulence screening using diverse essential oils and provides comprehensive data on the subject.
    CONCLUSIONS:
    This finding implies other beneficial effects of essential oils and suggests that black pepper, cananga, and myrrh oils have potential use as anti-virulence strategies against persistent S. aureus infections.
    Antimicrob Agents Chemother. 2005 May;49(5):1679-87.
    Antileishmanial activity of the terpene nerolidol.[Pubmed: 15855481 ]
    The activity of nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs, was evaluated against Leishmania species.
    METHODS AND RESULTS:
    Nerolidol inhibited the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 microM, respectively. The treatment of L. amazonensis-infected macrophages with 100 microM nerolidol resulted in 95% reduction in infection rates. Inhibition of isoprenoid biosynthesis, as shown by reduced incorporation of [2-(14)C]mevalonic acid (MVA) or [1-(14)C]acetic acid precursors into dolichol, ergosterol, and ubiquinone, was observed in nerolidol-treated promastigotes. This drug effect can be attributed to the blockage of an early step in the mevalonate pathway, since incorporation of the precursor [1(n)-(3)H]farnesyl pyrophosphate in polyisoprenoids is not inhibited by nerolidol. L. amazonensis-infected BALB/c mice were treated with intraperitoneal doses of 100 mg/kg/day for 12 days or topically with 5 or 10% ointments for 4 weeks. Significant reduction of lesion sizes in nerolidol treated mice was observed for both treatment routes. However, long-term follow up indicated that the disease was not cured in this highly susceptible animal model.
    CONCLUSIONS:
    Nonetheless, the in vitro activity of nerolidol against these parasites may prove a useful tool for the development of new drugs for the treatment of leishmaniasis. In addition, biosynthesis of dolichols with 11 and 12 isoprene units was identified in Leishmania, as described for other trypanosomatids and Apicomplexa.
    J.Chem. Ecol., 1980, 6(4):845-51.
    Nerolidol: An antifeeding sesquiterpene alcohol for gypsy moth larvae fromMelaleuca leucadendron[Reference: WebLink]
    A systematic procedure is reported for the isolation of a feeding deterrent, (E,S)-nerolidol (I), fromMelaleuca leucadendron leaves for the gypsy moth larvae. Testing of the related alcohols, farnesol (II) and geraniol (III) showed them to be deterrent, but the simpler isoprene-related compounds, 2-methyl-3-buten-2-ol andt-amyl alcohol were inactive.
    In vivo:
    Neurochem Res. 2013 Sep;38(9):1861-70.
    Antioxidant effects of nerolidol in mice hippocampus after open field test.[Pubmed: 23765368]
    The aim of this study was to evaluate the neuroprotective effects of nerolidol in mice hippocampus against oxidative stress in neuronal cells compared to ascorbic acid (positive control) as well as evaluated the nerolidol sedative effects by open field test compared to diazepam (positive control).
    METHODS AND RESULTS:
    Thirty minutes prior to behavioral observation on open field test, mice were intraperitoneally treated with vehicle, nerolidol (25, 50 and 75 mg/kg), diazepam (1 mg/kg) or ascorbic acid (250 mg/kg). To clarify the action mechanism of of nerolidol on oxidative stress in animals subjected to the open field test, Western blot analysis of Mn-superoxide dismutase and catalase in mice hippocampus were performed. In nerolidol group, there was a significant decrease in lipid peroxidation and nitrite levels when compared to negative control (vehicle). However, a significant increase was observed in superoxide dismutase and catalase activities in this group when compared to the other groups. Vehicle, diazepam, ascorbic acid and nerolidol groups did not affected Mn-superoxide dismutase, catalase mRNA or protein levels.
    CONCLUSIONS:
    Our findings strongly support the hypothesis that oxidative stress occurs in hippocampus. Nerolidol showed sedative effects in animals subjected to the open field test. Oxidative process plays a crucial role on neuronal pathological consequence, and implies that antioxidant effects could be achieved using this sesquiterpene.
    Carcinogenesis. 1991 Jan;12(1):151-2.
    Inhibition of azoxymethane-induced neoplasia of the large bowel by 3-hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene (nerolidol).[Pubmed: 1988176]
    The inhibitory capacities of four terpenes on azoxymethane (AOM)-induced neoplasia of the large bowel and duodenum was studied in male F344 rats.
    METHODS AND RESULTS:
    A complete course of AOM administrations was given and 3 days later the rats were fed a semipurified diet containing 5 mg/g of the test compounds, i.e. 3-hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene (nerolidol), beta-citronellol, (+/-)-linalool and (1R,2S,5R)-(-)-menthol or a corresponding control diet. The experiment was terminated 22 weeks after the last dose of AOM. Under these conditions, nerolidol showed an inhibitory effect on carcinogenesis of the large bowel. The number of rats bearing large bowel neoplasms (adenomas) was reduced from 82% in the controls to 33% in rats fed nerolidol and the number of tumors/rat from 1.5 in the controls to 0.7 in the nerolidol group. A reduction in adenocarcinomas of the duodenum was found but the data are not statistically significant.
    CONCLUSIONS:
    The effects of nerolidol are of interest in terms of the identification of a new inhibitor of carcinogenesis of the large bowel. The chemical structure of nerolidol suggests the possibility that the compound might have an impact on protein prenylation or some other aspect of the mevalonate pathway, but this remains to be established.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4964 mL 22.482 mL 44.964 mL 89.9281 mL 112.4101 mL
    5 mM 0.8993 mL 4.4964 mL 8.9928 mL 17.9856 mL 22.482 mL
    10 mM 0.4496 mL 2.2482 mL 4.4964 mL 8.9928 mL 11.241 mL
    50 mM 0.0899 mL 0.4496 mL 0.8993 mL 1.7986 mL 2.2482 mL
    100 mM 0.045 mL 0.2248 mL 0.4496 mL 0.8993 mL 1.1241 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式-橙花叔醇; Nerolidol CFN98638 7212-44-4 C15H26O = 222.4 20mg QQ客服:2056216494
    9-氧代橙花叔醇; 9-Oxonerolidol CFN98997 58865-88-6 C15H24O2 = 236.4 5mg QQ客服:2056216494
    四羟基鲨稀; Tetrahydroxysqualene CFN99062 1043629-23-7 C30H50O4 = 474.7 5mg QQ客服:2056216494
    角鲨烯; Squalene CFN99208 111-02-4 C30H50 = 410.7 20mg QQ客服:1413575084
    三十碳六烯-2,3-二醇; Squalene-2,3-diol CFN99456 14031-37-9 C30H52O2 = 444.7 5mg QQ客服:2159513211
    番荔枝素; Annonacin CFN97856 111035-65-5 C35H64O7 = 596.89 5mg QQ客服:1413575084

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