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    Annonacin

    番荔枝素
    产品编号 CFN97856
    CAS编号 111035-65-5
    分子式 = 分子量 C35H64O7 = 596.89
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lipids
    植物来源 The herbs of Annona glabra
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    番荔枝素 CFN97856 111035-65-5 1mg QQ客服:3257982914
    番荔枝素 CFN97856 111035-65-5 5mg QQ客服:3257982914
    番荔枝素 CFN97856 111035-65-5 10mg QQ客服:3257982914
    番荔枝素 CFN97856 111035-65-5 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sapienza University of Rome (Italy)
  • Universidad de La Salle (Mexico)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Wisconsin-Madison (USA)
  • Universidade de Franca (Brazil)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Universitas Airlangga (Indonesia)
  • Charles University in Prague (Czech Republic)
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  • Centrum Menselijke Erfelijkheid (Belgium)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Korea Institute of Oriental Medicine (Korea)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytother Res.2015, 29(7):1088-96
  • University of Limpopo2016, 1777
  • Nat Prod Sci.2016, 22(2)
  • J Ethnopharmacol.2017, 197:157-164
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Molecules.2017, 22(6)
  • Food Chem.2017, 228:301-314
  • Journal of Life Science2017, 233-240
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Drug Test Anal.2018, 10(10):1579-1589
  • Nutrients.2018, 10(12)
  • Int J Biol Macromol.2018, 112:1093-1103
  • PLoS One.2018, 13(3):e0193386
  • Int J Mol Sci.2018, 19(9):E2528
  • European Journal of Integrative Medicine2018, 20:165-172
  • Oncology Letters2018, 4690-4696
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Nutrients.2019, 12(1)
  • Int J Mol Sci.2019, 20(16):E4015
  • The Korea Journal of Herbology2019, 34(2):25-32
  • New Journal of Chemistry2019, 43:12538-12547
  • Biomolecules.2019, 9(11):E696
  • ...
  • 生物活性
    Description: Annonacin is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons; can cause significant cell death in various cancer cell lines. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases.
    Targets: CDK | P21 | ERK | JNK | STAT | Bcl-2/Bax | Caspase | Estrogen receptor | Progestogen receptor
    In vitro:
    Neurotoxicology. 2012 Jan;33(1):53-8.
    Annonacin in Asimina triloba fruit: implication for neurotoxicity.[Pubmed: 22130466]
    The acetogenin, Annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina triloba (pawpaw) is native to the Eastern United States and products are available online. This study determined whether Annonacin is in the pawpaw fruit pulp and whether it or the crude ethyl acetate extract is toxic to cortical neurons.
    METHODS AND RESULTS:
    Pawpaw extract was prepared by pulp extraction with methanol and liquid-liquid partitioning with ethyl acetate (EtOAc). Annonacin was isolated from the crude EtOAc extract via column chromatography using a gradient solvent system of increasing polarity. Mass spectroscopy, nuclear magnetic resonance and infrared spectroscopy were used to compare isolated material with synthetic Annonacin data and a natural Annonacin sample. Toxicity of isolated Annonacin and the total EtOAc extract was determined in primary rat cortical neurons using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The average concentration of Annonacin in the fruit pulp was 0.0701±0.0305mg/g. Purified Annonacin (30.07μg/ml) and crude EtOAc extract (47.96μg/ml) induced 50% death of cortical neurons 48h post treatment. Annonacin toxicity was enhanced in the presence of crude extract.
    CONCLUSIONS:
    Pawpaw fruit contains a high concentration of Annonacin, which is toxic to cortical neurons. Crude fruit extract also induced neurotoxicity, highlighting the need for additional studies to determine the potential risks of neurodegeneration associated with chronic exposure to pawpaw products.
    J Neurosci. 2007 Jul 18;27(29):7827-37.
    Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons.[Pubmed: 17634376]
    A neurodegenerative tauopathy endemic to the Caribbean island of Guadeloupe has been associated with the consumption of anonaceous plants that contain acetogenins, potent lipophilic inhibitors of complex I of the mitochondrial respiratory chain.
    METHODS AND RESULTS:
    To test the hypothesis that Annonacin, a prototypical acetogenin, contributes to the etiology of the disease, we investigated whether Annonacin affects the cellular distribution of the protein tau. In primary cultures of rat striatal neurons treated for 48 h with Annonacin, there was a concentration-dependent decrease in ATP levels, a redistribution of tau from the axons to the cell body, and cell death. Annonacin induced the retrograde transport of mitochondria, some of which had tau attached to their outer membrane.
    CONCLUSIONS:
    Therefore, the Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases.
    In vivo:
    Exp Neurol. 2014 Mar;253:113-25.
    Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.[Pubmed: 24389273]
    Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the tau gene have been associated with familial tauopathies, while Annonacin, a plant-derived mitochondrial inhibitor, has been implicated in an environmental form of tauopathy.
    METHODS AND RESULTS:
    We therefore determined whether there was a pathogenic synergy between Annonacin exposure and the expression of the R406W-tau mutation in transgenic mice. We found that Annonacin exposure caused an increase in the number of neurons with phosphorylated tau in the somatodendritic compartment in several brain areas in R406W(+/+) mice as opposed to mice that had only the endogenous mouse tau (R406W(-/-)). Western blot analysis demonstrated a concomitant increase in total tau protein without increase in tau mRNA, but reduced proteasomal proteolytic activity in R406W(+/+), but not R406W(-/-) mice, upon Annonacin-treatment. Phosphorylated tau levels exceeded the increase in total tau protein, along with increased levels of different tau kinases, foremost a striking increase in the p25/p35 ratio, known to activate the tau kinase Cdk5.
    CONCLUSIONS:
    In summary, we observed a synergistic interaction between Annonacin exposure and the presence of the R406W-tau mutation, which resulted in reduced degradation, increased phosphorylation and redistribution of neuronal tau.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6754 mL 8.3768 mL 16.7535 mL 33.507 mL 41.8838 mL
    5 mM 0.3351 mL 1.6754 mL 3.3507 mL 6.7014 mL 8.3768 mL
    10 mM 0.1675 mL 0.8377 mL 1.6754 mL 3.3507 mL 4.1884 mL
    50 mM 0.0335 mL 0.1675 mL 0.3351 mL 0.6701 mL 0.8377 mL
    100 mM 0.0168 mL 0.0838 mL 0.1675 mL 0.3351 mL 0.4188 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式-橙花叔醇; Nerolidol CFN98638 7212-44-4 C15H26O = 222.4 20mg QQ客服:2159513211
    9-氧代橙花叔醇; 9-Oxonerolidol CFN98997 58865-88-6 C15H24O2 = 236.4 5mg QQ客服:1148253675
    四羟基鲨稀; Tetrahydroxysqualene CFN99062 1043629-23-7 C30H50O4 = 474.7 5mg QQ客服:1413575084
    角鲨烯; Squalene CFN99208 111-02-4 C30H50 = 410.7 20mg QQ客服:3257982914
    三十碳六烯-2,3-二醇; Squalene-2,3-diol CFN99456 14031-37-9 C30H52O2 = 444.7 5mg QQ客服:3257982914
    番荔枝素; Annonacin CFN97856 111035-65-5 C35H64O7 = 596.89 5mg QQ客服:1148253675

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