Info: Read More
  • 中药标准品生产商,产品定制服务
  • 角鲨烯

    Squalene

    角鲨烯
    产品编号 CFN99208
    CAS编号 111-02-4
    分子式 = 分子量 C30H50 = 410.7
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Triterpenoids
    植物来源 The herbs of Catharanthus roseus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    角鲨烯 CFN99208 111-02-4 10mg QQ客服:215959384
    角鲨烯 CFN99208 111-02-4 20mg QQ客服:215959384
    角鲨烯 CFN99208 111-02-4 50mg QQ客服:215959384
    角鲨烯 CFN99208 111-02-4 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Periyar University (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Medizinische Universit?t Wien (Austria)
  • Harvard University (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Medical University of Gdansk (Poland)
  • University of Indonesia (Indonesia)
  • Universidad Veracuzana (Mexico)
  • University of South Australia (Australia)
  • Mahidol University (Thailand)
  • St. Jude Children Research Hospital (USA)
  • University of Stirling (United Kingdom)
  • Indian Institute of Science (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Drug Chem Toxicol.2020, 1-12.
  • Appl. Sci.2021, 11(1),14.
  • RSC Advances2017, 86
  • Life Sci.2022, 298:120488.
  • J Food Biochem.2019, 43(9):e12970
  • Antioxidants (Basel).2021, 10(10):1638.
  • Nutrients.2018, 10(7)
  • Metab Eng.2022, 75:143-152.
  • Food Res Int.2022, 157:111397.
  • Plant Physiol Biochem.2019, 144:355-364
  • Front Plant Sci.2020, 10:1705
  • Korean J of Medicinal Crop Science2018, 220-226
  • Molecules.2022, 27(13):4227.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Mol Med Rep.2015, 12(5):7789-95
  • Antioxidants (Basel).2022, 11(8):1471.
  • Mol Med Rep.2022, 25(1):8.
  • Int J Mol Sci.2023, 24(3):2102.
  • RSC Adv.2023, 13(9):6317-6326.
  • iScience.2023, 26(9):107602.
  • Indian J. of Experimental Bio.2020, 9(58).
  • Food Chem.2022, 378:131975.
  • ...
  • 生物活性
    Description: Squalene, a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.Squalene shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene can significantly suppress colonic aberrant crypt foci (ACF) formation and crypt multiplicity strengthens the hypothesis that squalene possesses chemopreventive activity against colon carcinogenesis.
    Targets: COX | STAT | FOXP3 | Nrf2 | SOD | GPx
    In vivo:
    Mol Nutr Food Res. 2015 Feb;59(2):284-92.
    Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFkB signaling pathways.[Pubmed: 25387687]
    Squalene is a polyunsaturated triterpene, which has exhibited anticancer and antioxidant activities among others. We investigated dietary squalene supplementation effect on an acute colitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice.
    METHODS AND RESULTS:
    Mice were fed from weaning with squalene at 0.02% and 0.1%. After 4 weeks, mice were exposed to 3% DSS for 5 days developing acute colitis. After DSS removal (5 days), colons were histological and biochemically processed. Our results showed that dietary squalene treatment exerts anti-inflammatory action in DSS-induced acute colitis. Western blot revealed that squalene downregulated COX-2 (where COX is cyclooxygenase) and inducible nitric oxide synthase system by inhibition of mitogen-activated protein kinase p38 and the nuclear factor-kappa B signaling pathways, preventing an increase in the cytokines levels. Under our experimental conditions, STAT3 and FOXP3 (where FOXP3 is forkhead box P3) were not modified and the transcriptional regulation of antioxidant and/or detoxifying enzymes, Nrf2 (where Nrf2 is nuclear factor (erythroid-derived 2)-like 2), was reduced in DSS-induced colitis. However, any change could be observed after squalene supplementation.
    CONCLUSIONS:
    Squalene was able to improve the oxidative events and returned proinflammatory proteins expression to basal levels probably through p38 mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. However, supplementary studies are needed in order to provide a basis for developing a new dietary supplementation strategy.
    Clin Chim Acta. 2006 Feb;364(1-2):335-42.
    Effect of squalene on cyclophosphamide-induced toxicity.[Pubmed: 16150433]
    Toxicity due to drugs used for neoplastic disorders is extensively documented. Cyclophosphamide (CYP) is a widely used antineoplastic drug, which could cause toxicity of normal cells due to its toxic metabolites. We evaluated the protective role of squalene (SQ) in the toxicity induced by cyclophosphamide.
    METHODS AND RESULTS:
    The activities of serum marker enzymes, clinical chemistry parameters and histopathology studies were done according to the standard procedures in the control and experimental groups of rats. Toxicity of the organs like heart, kidney and liver was evidenced from significant (P<0.05) increases of CK, LDH, AST, ALT, ALP, urea, creatinine and total bilirubin in cyclophosphamide- (150 mg/kg for 2 days) administered rats. Abnormal activities of these enzymes in the organs and serum total protein and cholesterol were also observed. No significant changes were observed in triglycerides in serum. Squalene oral treatment exerted protection towards these organs at a dose of 0.4 ml/day/rat. Histopathological examinations also confirmed the protective efficacy of squalene.
    CONCLUSIONS:
    Squalene may be efficacious as a cytoprotectant in cyclophosphamide-induced toxicities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4349 mL 12.1743 mL 24.3487 mL 48.6973 mL 60.8717 mL
    5 mM 0.487 mL 2.4349 mL 4.8697 mL 9.7395 mL 12.1743 mL
    10 mM 0.2435 mL 1.2174 mL 2.4349 mL 4.8697 mL 6.0872 mL
    50 mM 0.0487 mL 0.2435 mL 0.487 mL 0.9739 mL 1.2174 mL
    100 mM 0.0243 mL 0.1217 mL 0.2435 mL 0.487 mL 0.6087 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式-橙花叔醇; Nerolidol CFN98638 7212-44-4 C15H26O = 222.4 20mg QQ客服:3257982914
    9-氧代橙花叔醇; 9-Oxonerolidol CFN98997 58865-88-6 C15H24O2 = 236.4 5mg QQ客服:3257982914
    (Z)-3,11-dimethy-7-methylene-9,14-epoxy-1,6,10-dodecatrien-3-ol; (Z)-3,11-dimethy-7-methylene-9,14-epoxy-1,6,10-dodecatrien-3-ol CFN95402 1392202-57-1 C15H24O2 = 236.4 10mg QQ客服:1457312923
    四羟基鲨稀; Tetrahydroxysqualene CFN99062 1043629-23-7 C30H50O4 = 474.7 5mg QQ客服:1413575084
    角鲨烯; Squalene CFN99208 111-02-4 C30H50 = 410.7 20mg QQ客服:2056216494
    三十碳六烯-2,3-二醇; Squalene-2,3-diol CFN99456 14031-37-9 C30H52O2 = 444.7 5mg QQ客服:215959384
    番荔枝素; Annonacin CFN97856 111035-65-5 C35H64O7 = 596.89 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产