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    柚皮芸香苷

    Narirutin

    柚皮芸香苷
    产品编号 CFN99543
    CAS编号 14259-46-2
    分子式 = 分子量 C27H32O14 = 580.53
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The young fruits of Citrus grandis (L.) Osbeck.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柚皮芸香苷 CFN99543 14259-46-2 10mg QQ客服:1413575084
    柚皮芸香苷 CFN99543 14259-46-2 20mg QQ客服:1413575084
    柚皮芸香苷 CFN99543 14259-46-2 50mg QQ客服:1413575084
    柚皮芸香苷 CFN99543 14259-46-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Cincinnati (USA)
  • Ateneo de Manila University (Philippines)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Center for protein Engineering (CIP) (Belgium)
  • Universidade Católica Portuguesa (Portugal)
  • Chungnam National University (Korea)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Queensland (Australia)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Anna University (India)
  • Gyeongsang National University (Korea)
  • Subang Jaya Medical Centre (Malaysia)
  • John Innes Centre (United Kingdom)
  • Mahidol University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Med Food.2016, 19(12):1155-1165
  • HortTechnology2016, 26(6):816-819
  • Oncol Rep.2016, 35(3):1356-64
  • Int J Mol Sci.2017, 18(5)
  • Integr Med Res.2017, 6(4):395-403
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Neurochem Int.2018, 121:114-124
  • PLoS One.2018, 13(3):e0193386
  • Neuropharmacology.2018, 131:68-82
  • World J Mens Health.2019, 10.5534
  • Pharmacognosy Journal2019, 11(2): 369-373
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Genes Genomics.2020, 10.1007
  • Molecules.2020, 25(3):734
  • Antioxidants (Basel).2020, 9(2): E119
  • Dent Mater J.2020, 39(4):690-695
  • Plant Archives2020, 2(1),2929-2934
  • J Vet Sci.2020, 21(3):e39.
  • Bioorg Med Chem.2020, 28(12):115553.
  • Biosci Rep.2020, 40(8):BSR20201219.
  • J Ginseng Res.2020, 44(4):611-618.
  • J Nat Med.2020, 74(3):550-560.
  • Biology (Basel).2020, 9(11):363.
  • ...
  • 生物活性
    Description: Citrus narirutin fraction (CNF), contained 75% of narirutin, co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines. Narirutin has anti-inflammatory effect in a murine model of allergic eosinophilic airway inflammation, the mechanism is likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE.
    Targets: NO | NOS | PGE | COX | TNF-α | NF-kB | MAPK | IL Receptor
    In vitro:
    Food Chem Toxicol. 2012 Oct;50(10):3498-504.
    Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation.[Pubmed: 22813871]

    METHODS AND RESULTS:
    In this study, we examined the regulatory activity of narirutin fraction from citrus peels on the production of inflammatory mediators managing acute or chronic inflammatory diseases in macrophages. Narirutin fraction inhibited the release, by lipopolysaccharide (LPS)-stimulated macrophages, of nitric oxide (NO) and prostaglandin E2 (PGE2) through suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively. The release, by LPS stimulated macrophages, of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) was also reduced by narirutin fraction in a dose-dependent manner. Furthermore, narirutin fraction inhibited the LPS-mediated activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs), which are signaling molecules involved in production of pro-inflammatory factors.
    CONCLUSIONS:
    As a result of these properties, narirutin fraction has the potential to be used as a functional dietary supplement and effective anti-inflammatory agent.
    In vivo:
    Food Chem Toxicol. 2013 May;55:637-44.
    Narirutin fraction from citrus peels attenuates alcoholic liver disease in mice.[Pubmed: 23416143]

    METHODS AND RESULTS:
    This study aimed to demonstrate protective activities of the narirutin fraction from peels of Citrus unshiu against ethanol-induced hepatic damage through an animal study. Citrus narirutin fraction (CNF), contained 75% of narirutin, was obtained by an ultra-sonicated extraction and further purification. ICR mice were divided into four groups; normaldiet control, ethanol control (6.5g ethanol/kg), low-CNF (ethanol+150mg CNF/kg) and high-CNF (ethanol+300mg CNF/kg) groups. Consumption of alcohol for 8weeks induced severe liver damage with increases in prognostic indicators such as aspartate transaminase, alanine transaminase in serum whereas co-administration of CNF suppressed their increases. Excessive accumulations in liver TG and TC in ethanol control group were also suppressed by co-administration of CNF. Co-administration of CNF maintained SOD activity, GSH and malondialdehyde levels close to those of the normal diet group. Chronic consumption of alcohol also stimulated abrupt increases in pro-inflammatory cytokines such as nuclear factor (NF)-κB, tumor necrosis factor (TNF)-α and interleukin (IL)-1β in liver otherwise co-administration of CNF effectively suppressed production of these cytokines dose-dependently.
    CONCLUSIONS:
    These results indicate that co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7226 mL 8.6128 mL 17.2256 mL 34.4513 mL 43.0641 mL
    5 mM 0.3445 mL 1.7226 mL 3.4451 mL 6.8903 mL 8.6128 mL
    10 mM 0.1723 mL 0.8613 mL 1.7226 mL 3.4451 mL 4.3064 mL
    50 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.689 mL 0.8613 mL
    100 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Pyrroside B; Pyrroside B CFN96142 116271-35-3 C26H30O14 = 566.5 5mg QQ客服:2932563308
    5,6,7,4'-四羟基黄酮 6,7-二葡萄糖苷; 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside CFN92520 501434-65-7 C27H32O16 = 612.5 5mg QQ客服:2159513211
    异樱花苷; Isosakuranin CFN92809 491-69-0 C22H24O10 = 448.1 10mg QQ客服:2056216494
    枸橘苷; Poncirin CFN90448 14941-08-3 C28H34O14 = 594.56 20mg QQ客服:2056216494
    香风草甙; Didymin CFN92363 14259-47-3 C28H34O14 = 594.6 20mg QQ客服:2159513211
    异柚葡糖苷; Isohemiphloin CFN98602 3682-02-8 C21H22O10 = 434.4 5mg QQ客服:2159513211
    杜鹃素 7-O-葡萄糖苷; Farrerol 7-O-glucoside CFN96281 885044-12-2 C23H26O10 = 462.5 5mg QQ客服:2056216494
    Flavaprin; Flavaprin CFN98900 53846-49-4 C26H30O10 = 502.5 5mg QQ客服:1457312923
    甘草苷; Liquiritin CFN99154 551-15-5 C21H22O9 = 418.39 20mg QQ客服:2056216494
    芹糖甘草苷; Liquiritin apioside CFN90707 199796-12-8 C26H30O13 = 550.5 20mg QQ客服:1413575084

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