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  • 甘草苷

    Liquiritin

    甘草苷
    产品编号 CFN99154
    CAS编号 551-15-5
    分子式 = 分子量 C21H22O9 = 418.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza glabra L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草苷 CFN99154 551-15-5 10mg QQ客服:2159513211
    甘草苷 CFN99154 551-15-5 20mg QQ客服:2159513211
    甘草苷 CFN99154 551-15-5 50mg QQ客服:2159513211
    甘草苷 CFN99154 551-15-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Calcutta University (India)
  • Korea Institute of Oriental Medicine (Korea)
  • Chiang Mai University (Thailand)
  • University of Ioannina (Greece)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Amity University (India)
  • Mendel University in Brno (Czech Republic)
  • University of Virginia (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Universiti Sains Malaysia (Malaysia)
  • University of Bordeaux (France)
  • Heidelberg University (Germany)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Almansora University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Phytomedicine.2015, 22(14):1262-8
  • Phytochemistry Letters2015, 243-247
  • J Agric Food Chem.2015, 63(44):9869-78
  • Molecules.2016, 21(6)
  • US20170000760 A12016, 42740
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Nat Prod Commun.2017, 12(5):771-778
  • Plant Methods.2017, 13:108
  • J Ethnopharmacol.2017, 198:205-213
  • Sci Rep. 2017, 8207(7)
  • Nutrients.2018, 10(12):E1998
  • Microchemical Journal2018, 137:168-173
  • Phytother Res.2018, 32(12):2551-2559
  • Oncology Letters2018, 4690-4696
  • Phytomedicine.2018, 47:48-57
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Sci Rep.2018, 8:15059
  • Front Pharmacol.2019, 10:1355
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Molecules.2019, 24(11):E2102
  • New Journal of Chemistry2019, 43:12538-12547
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • ...
  • 生物活性
    Description: Liquiritin possesses antidepressant-like, neuroprotective , antioxidant, antiapoptosis, anti-inflammatory and anti-cancer abilities. Liquiritin can attenuate advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells, it may be a promising agent for the treatment of vasculopathy in diabetic patients.
    Targets: GSK-3 | ERK | Akt | NF-kB | 5-HT Receptor | RAGE
    In vitro:
    Biomed Chromatogr. 2014 Sep;28(9):1271-7.
    Effect of liquiritin on human intestinal bacteria growth: metabolism and modulation.[Pubmed: 24616071]
    Licorice is one of the oldest and most frequently used prescribed traditional Chimese medicines. However, the route and metabolites of liquiritin by human intestinal microflora are not well understood and its metabolites may accumulate to exert physiological effects.
    METHODS AND RESULTS:
    Therefore, our objective was to screen the ability of the bacteria to metabolize liquiritin and assess the effect of this compound on the intestinal bacteria. Finally, six strains, comprising Bacteroides sp. 22 and sp.57, Veillonella sp. 31 and sp.48, Bacillus sp. 46 and Clostridium sp. 51, were isolated and their abilities to convert liquiritin studied. A total of five metabolites were identified using ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry in human incubated solution. The results indicated that hydrolysis, hydrogenation, methylation, deoxygenation and acetylation were the major routes of metabolism of liquiritin. On the other hand, effect of liquiritin on different strains of intestinal bacteria growth was detected using an Emax precision microplate reader. Growth of certain pathogenic bacteria, such as Enterobacter, Enterococcus, Clostridium and Bacteroides, was significantly repressed by liquiritin, while growth of commensal probiotics such as Lactobacillus and Bifidobacterium was less severely affected.
    CONCLUSIONS:
    Our observation provided further evidence for the importance of intestinal bacteria in the metabolism, and the potential activity of liquiritin in human health and disease.
    Mol Cell Biochem. 2013 Feb;374(1-2):191-201.
    Liquiritin attenuates advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells.[Pubmed: 23229233]
    Advanced glycation end products (AGEs)-induced vasculopathy, including oxidative stress, inflammation and apoptosis responses, contributes to the high morbidity and mortality of coronary artery diseases in diabetic patients.
    METHODS AND RESULTS:
    The present study was conducted to evaluate the protective activity of liquiritin (Liq) on AGEs-induced endothelial dysfunction and explore its underlying mechanisms. After pretreatment with Liq, a significant reduction in AGEs-induced apoptosis, as well as reactive oxygen species generation and malondialdehyde level in human umbilical vein endothelial cells (HUVECs) were observed via acridine orange/ethidium bromide fluorescence staining test. Notably, Liq also significantly increased AGEs-reduced superoxide dismutase activity. Furthermore, the pretreatment with receptor for advanced glycation end products (RAGE)-antibody or Liq remarkably down-regulated TGF-beta1 and RAGE protein expressions and significantly blocked NF-κB activation which were proved by immunocytochemistry or immunofluorescence assays.
    CONCLUSIONS:
    These results indicated that Liq held potential for the protection on AGEs-induced endothelial dysfunction via RAGE/NF-κB pathway in HUVECs and might be a promising agent for the treatment of vasculopathy in diabetic patients.
    In vivo:
    Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1179-84.
    Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice.[Pubmed: 18289754]

    METHODS AND RESULTS:
    Two classic animal behavior despair tests--the Forced Swimming Test (FST) and the Tail Suspension Test (TST) were used to evaluate the antidepressant activity of liquiritin and isoliquiritin from Glycyrrhiza uralensis in mice. It was observed that both liquiritin and isoliquiritin at doses of 10, 20 and 40 mg/kg significantly reduced the immobility time in the FST and TST in mice 30 min after treatment. Measurement of locomotor activity indicated that liquiritin and isoliquiritin had no central nervous system (CNS)-stimulating effects. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. It was found that these two compounds significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus and cortex. Liquiritin and isoliquiritin also significantly reduced the ratio of 5-HIAA/5-HT in the hippocampus, hypothalamus and cortex, slowing down 5-HT metabolism compared with mice treated with vehicle+stress.
    CONCLUSIONS:
    In conclusion, liquiritin and isoliquiritin produced significant antidepressant-like effects, and their mechanism of action may be due to increased 5-HT and NE in the mouse hippocampus, hypothalamus and cortex.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3901 mL 11.9506 mL 23.9011 mL 47.8023 mL 59.7529 mL
    5 mM 0.478 mL 2.3901 mL 4.7802 mL 9.5605 mL 11.9506 mL
    10 mM 0.239 mL 1.1951 mL 2.3901 mL 4.7802 mL 5.9753 mL
    50 mM 0.0478 mL 0.239 mL 0.478 mL 0.956 mL 1.1951 mL
    100 mM 0.0239 mL 0.1195 mL 0.239 mL 0.478 mL 0.5975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    葡萄糖基甘草苷; Glucoliquiritin CFN95011 93446-18-5 C27H32O14 = 580.5 10mg QQ客服:2932563308
    樱桃甙; 洋李甙; Prunin CFN98878 529-55-5 C21H22O10 = 434.4 10mg QQ客服:1413575084
    柚皮苷; Naringin CFN99555 10236-47-2 C27H32O14 = 580.53 20mg QQ客服:2159513211
    柚皮苷 4'-葡萄糖苷; Naringin 4'-glucoside CFN95014 17257-21-5 C33H42O19 = 742.7 5mg QQ客服:2159513211
    柚皮芸香苷; Narirutin CFN99543 14259-46-2 C27H32O14 = 580.53 20mg QQ客服:1148253675
    Pyrroside B; Pyrroside B CFN96142 116271-35-3 C26H30O14 = 566.5 5mg QQ客服:2932563308
    5,6,7,4'-四羟基黄酮 6,7-二葡萄糖苷; 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside CFN92520 501434-65-7 C27H32O16 = 612.5 5mg QQ客服:1413575084
    异樱花苷; Isosakuranin CFN92809 491-69-0 C22H24O10 = 448.1 10mg QQ客服:215959384
    枸橘苷; Poncirin CFN90448 14941-08-3 C28H34O14 = 594.56 20mg QQ客服:2159513211
    香风草甙; Didymin CFN92363 14259-47-3 C28H34O14 = 594.6 20mg QQ客服:2932563308

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