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  • 柚皮苷

    Naringin

    柚皮苷
    产品编号 CFN99555
    CAS编号 10236-47-2
    分子式 = 分子量 C27H32O14 = 580.53
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus maxima.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柚皮苷 CFN99555 10236-47-2 10mg QQ客服:2932563308
    柚皮苷 CFN99555 10236-47-2 20mg QQ客服:2932563308
    柚皮苷 CFN99555 10236-47-2 50mg QQ客服:2932563308
    柚皮苷 CFN99555 10236-47-2 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Malaya (Malaysia)
  • University of Toulouse (France)
  • Washington State University (USA)
  • Mendel University in Brno (Czech Republic)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Wroclaw Medical University (Poland)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Pretoria (South Africa)
  • Nanjing University of Chinese Medicine (China)
  • National Research Council of Canada (Canada)
  • Mahidol University (Thailand)
  • University of Dicle (Turkey)
  • University of Virginia (USA)
  • University of Medicine and Pharmacy (Romania)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2014, 9(5):679-82
  • Pharmacogn Mag.2015, 11:S585-91
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • J Nat Prod.2015, 78(6):1339-4
  • Phytomedicine.2016, 23(4):331-9
  • Int J Mol Sci.2017, 18(5)
  • Int J Anal Chem.2017, 2017:1254721
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Universidade Estadual Paulista2017, 42785
  • The Japan Society for Analytical Chemistry2017, 613-617
  • PLoS One.2018, 13(3):e0193386
  • Int J Mol Sci.2018, 19(2)
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Chemistry of Natural Compounds2018, 204–206
  • Nat Prod Sci.2018, 24(3):206
  • Food Chem.2018, 262:78-85
  • Biol Pharm Bull.2018, 41(1):65-72
  • Pathogens.2018, 7(3):E62
  • Wageningen University & Research2018, January 2018
  • J Funct Foods2019, 54:449-456
  • J Pharmaceut Biomed2020, 178:112894
  • J Ethnopharmacol.2020, 249:112381
  • Food Chem.2020, 313:126079
  • ...
  • 生物活性
    Description: Naringin exhibits antioxidant, anti-atherogenic, antiulcer, anti-hypocholesterolemic, anti-lipoperoxidative, and anti-hyperglycemia effects. Naringin reduces Ara-C-induced oxidative stress through both an inhibition of the generation of ROS production and an increase in antioxidant enzyme activities, it blocks apoptosis caused by Ara-C-induced oxidative stress, resulting in the inhibition of the cytotoxicity of Ara-C. Naringin attenuates epidermal growth factor (EGF)-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways.
    Targets: p21 | Wnt/β-catenin | p38MAPK | JNK | NF-kB | p65 | AP-1 | IkB | EGFR | IKK
    In vitro:
    J Pharmacol Sci. 2003 Jun;92(2):166-70.
    Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells.[Pubmed: 12832847]
    Flavonoids are widely recognized as naturally occurring antioxidants. Naringin (NG) is one of the flavonoid components in citrus fruits such as grapefruit. Hydrogen peroxide (H2O2) causes cytotoxicity through oxidative stress and apoptosis.
    METHODS AND RESULTS:
    In this paper, we examined the effects of NG on H2O2-induced cytotoxicity and apoptosis in mouse leukemia P388 cells. Cytotoxicity was determined by mitochondrial activity (MTT assay). Apoptosis and DNA damage were analyzed by measuring chromatin condensation and Comet assay (alkaline single cell gel electrophoresis), respectively. H2O2-induced cytotoxicity was significantly attenuated by NG or the reduced form of glutathione (GSH), a typical intracellular antioxidant. NG suppressed chromatin condensation and DNA damage induced by H2O2.
    CONCLUSIONS:
    These results indicate that NG from natural products is a useful drug having antioxidant and anti-apoptopic properties.
    In vivo:
    J Pharm Bioallied Sci. 2015 Apr-Jun;7(2):121-7.
    Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats.[Pubmed: 25883516]
    Renal artery occlusion (RAO) induced hypertension is a major health problem associated with structural and functional variations of the renal and cardiac vasculature. Naringin a flavanone glycoside derived possesses metal-chelating, antioxidant and free radical scavenging properties. The objective of this study was to investigate the antihypertensive activity of Naringin in RAO induced hypertension in rats.
    METHODS AND RESULTS:
    Male Wistar rats (180-200 g) were divided into five groups Sham, RAO, Naringin (20, 40 and 80 mg/kg). Animals were pretreated with Naringin (20, 40 and 80 mg/kg p.o) for 4 weeks. On the last day of the experiment, left renal artery was occluded with renal bulldog clamp for 4 h. After assessment of hemodynamic and left ventricular function various biochemical (superoxide dismutase [SOD], glutathione [GSH] and malondialdehyde [MDA]) and histological parameters were determined in the kidney. RESULTS: RAO group significantly (P < 0.001) increased hemodynamic parameters at 15, 30 and 45 min of clamp removal. Naringin (40 and 80 mg/kg) treated groups showed a significant decrease in hemodynamic parameters at 15 min. after clamp removal that remained sustained for 60 min. Naringin (40 and 80 mg/kg) treated groups showed significant improvement in left ventricular function at 15, 30 and 45 min after clamp removal. Alteration in level of SOD, GSH and MDA was significantly restored by Naringin (40 and 80 mg/kg) treatment. It also reduced histological aberration induced in kidney by RAO.
    CONCLUSIONS:
    It is concluded that the antihypertensive activity of naringin may result through inhibition of oxidative stress.
    Life Sci. 2010 Jun 19;86(25-26):928-35.
    Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice.[Pubmed: 20433854 ]
    The present study has been designed to explore the nitric oxide mechanism in the protective effect of naringin against I/R induced neurobehavioral alterations, oxidative damage and mitochondrial dysfunction in mice.
    METHODS AND RESULTS:
    Laca mice (25-30 g) were subjected twice to BCCAO occlusion (5 min) at the interval of 10 min, followed by 96 h reperfusion. Naringin (50 and 100 mg/kg) was administered for 10 days, starting 7 days before the animals were subjected to I/R injury. On day 10, various neurobehavioral parameters followed by biochemical parameters and mitochondrial enzyme complex activities were assessed. Ischemia reperfusion injury caused significant (increased immobility period, neurological score and decreased locomotor activity) oxidative damage (increased lipid peroxidation and nitrite concentration and depleted reduced glutathione, glutathione-S-transferase, superoxide dismutase and catalase) and altered mitochondrial enzyme complex activities (complex I to IV) as compared to sham treatment. Naringin (50 and 100 mg/kg) treatment significantly attenuated neurobehavioral alterations, oxidative damage and restored mitochondrial enzyme complex activities as compared to control (ischemia reperfusion) group. Further, protective effect of naringin (50 mg/kg) was attenuated by l-arginine (100 mg/kg) or sildenafil (5 mg/kg) pretreatment. Further, L-NAME (10 mg/kg) or 7-NI (10 mg/kg) pretreatment with naringin (50 mg/kg) significantly potentiated their protective effect as compared to their treatment alone.
    CONCLUSIONS:
    The present study suggests the involvement of nitric oxide mechanism in the protective effect of naringin against post-stroke depression induced neurobehavioral, biochemical and cellular alterations in mice.
    Toxicology. 2007 Feb 12;230(2-3):178-88.
    Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.[Pubmed: 17188415 ]
    Diets rich in natural antioxidants are associated with reduced risk of heart diseases.
    METHODS AND RESULTS:
    This study was aimed to evaluate the preventive role of naringin on cardiac troponin T (cTnT), lactate dehydrogenase (LDH)-isoenzyme, cardiac marker enzymes, electrocardiographic (ECG)-patterns and lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85mg/kg) at an interval of 24h for 2 days showed a significant increase in the levels of cTnT, intensity of the bands of LDH-isoenzyme (LDH1 and LDH2) and the activities of cardiac marker enzymes such as creatine kinase-MB (CK-MB), creatine kinase (CK), LDH, aspartate transaminase (AST) and alanine transaminase (ALT) in serum with subsequent decrease in the activities of CK, LDH, AST and ALT in the heart and alterations in ECG-patterns. The activities of lysosomal enzymes (beta-glucuronidase, beta-N-acetyl glucosaminidase, beta-galactosidase, cathepsin-B and cathepsin-D) were increased significantly in serum and the heart of ISO-induced rats, but the activities of beta-glucuronidase and cathepsin-D were decreased significantly in the lysosomal fraction of the heart. Pretreatment with naringin (10, 20 or 40mg/kg) daily for a period of 56 days positively altered the levels of cTnT, intensity of the bands of the LDH1 and LDH2-isoenzyme and the activities of cardiac marker enzymes, ECG-patterns and lysosomal hydrolases in ISO-induced rats.
    CONCLUSIONS:
    Thus, naringin possess cardioprotective effect in ISO-induced MI in rats.
    Pharmacology. 1994 Sep;49(3):144-50.
    Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.[Pubmed: 7972328]
    This study was designed to determine the gastroprotective properties of naringin on and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol.
    METHODS AND RESULTS:
    Oral pretreatment with the highest dose of naringin (400 mg/kg), 60 min before absolute ethanol was the most effective antiulcer treatment. Subcutaneous administration of indomethacin (10 mg/kg) to the animals treated with naringin (400 mg/kg) partially inhibited gastric protection, but the prostaglandin E2 determination did not show any increase in prostanoid levels. The contents of gastric mucus and total proteins were not significantly modified. Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indomethacin.
    CONCLUSIONS:
    These results show that naringin has a 'cytoprotective' effect against ethanol injury in the rat, but this property appears to be mediated by non-prostaglandin-dependent mechanisms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7226 mL 8.6128 mL 17.2256 mL 34.4513 mL 43.0641 mL
    5 mM 0.3445 mL 1.7226 mL 3.4451 mL 6.8903 mL 8.6128 mL
    10 mM 0.1723 mL 0.8613 mL 1.7226 mL 3.4451 mL 4.3064 mL
    50 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.689 mL 0.8613 mL
    100 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草苷; Liquiritin CFN99154 551-15-5 C21H22O9 = 418.39 20mg QQ客服:3257982914
    芹糖甘草苷; Liquiritin apioside CFN90707 199796-12-8 C26H30O13 = 550.5 20mg QQ客服:1148253675
    葡萄糖基甘草苷; Glucoliquiritin CFN95011 93446-18-5 C27H32O14 = 580.5 10mg QQ客服:3257982914
    樱桃甙; 洋李甙; Prunin CFN98878 529-55-5 C21H22O10 = 434.4 10mg QQ客服:3257982914
    柚皮苷; Naringin CFN99555 10236-47-2 C27H32O14 = 580.53 20mg QQ客服:1148253675
    柚皮苷 4'-葡萄糖苷; Naringin 4'-glucoside CFN95014 17257-21-5 C33H42O19 = 742.7 5mg QQ客服:3257982914
    柚皮芸香苷; Narirutin CFN99543 14259-46-2 C27H32O14 = 580.53 20mg QQ客服:1413575084
    Pyrroside B; Pyrroside B CFN96142 116271-35-3 C26H30O14 = 566.5 5mg QQ客服:1148253675
    5,6,7,4'-四羟基黄酮 6,7-二葡萄糖苷; 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside CFN92520 501434-65-7 C27H32O16 = 612.5 5mg QQ客服:2159513211
    异樱花苷; Isosakuranin CFN92809 491-69-0 C22H24O10 = 448.1 10mg QQ客服:1148253675

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