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    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮

    Moslosooflavone

    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮
    产品编号 CFN98475
    CAS编号 3570-62-5
    分子式 = 分子量 C17H14O5 = 298.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Mosla soochouensis Matsuda
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮 CFN98475 3570-62-5 10mg QQ客服:1413575084
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮 CFN98475 3570-62-5 20mg QQ客服:1413575084
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮 CFN98475 3570-62-5 50mg QQ客服:1413575084
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮 CFN98475 3570-62-5 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Colorado State University (USA)
  • Nanjing University of Chinese Medicine (China)
  • Sant Gadge Baba Amravati University (India)
  • University of Vigo (Spain)
  • Deutsches Krebsforschungszentrum (Germany)
  • The Institute of Cancer Research (United Kingdom)
  • Lund University (Sweden)
  • The Ohio State University (USA)
  • Lodz University of Technology (Poland)
  • Michigan State University (USA)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Helmholtz Zentrum München (Germany)
  • Monash University (Australia)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Med. Plant Research.2013, 90-151
  • Exp Parasitol.2015, 153:160-4
  • Acta Physiologiae Plantarum2015, 37:1736
  • Mediators Inflamm.2016, 2016:7216912
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Molecules.2017, 22(3)
  • J Agric Food Chem.2017, 65(13):2670-2676
  • Nat Chem Biol.2018, 14(8):760-763
  • Integr Cancer Ther.2018, 17(3):832-843
  • Mol Cells.2018, 41(8):771-780
  • Pharmacol Rep.2018, 70(6):1195-1201
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Toxins (Basel).2019, 11(10):E575
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Sci Rep.2019, 9(1):6429
  • Metabolites.2019, 9(11):E271
  • Br J Pharmacol.2020, 10.1111
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Chemistry of Natural Compounds2020, 56,423-426
  • J Agric Food Chem.2020, 68(51):15164-15175
  • ...
  • 生物活性
    Description: Moslosooflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. Moslosooflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.
    Targets: NF-kB | IFN-γ | IL Receptor | NO | TNF-α
    In vitro:
    J Agric Food Chem. 2010 Feb 24;58(4):2505-12.
    Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.[Pubmed: 20085279]
    Previous studies showed that the ethyl acetate (EtOAc) fraction of Andrographis paniculata (AP) possessed anti-inflammatory activity. This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds.
    METHODS AND RESULTS:
    Reporter gene assay indicated that 5-hydroxy-7,8-dimethoxyflavone (1), Moslosooflavone (2), a mix of beta-sitosterol (3a) and stigmasterol (3b), ergosterol peroxide (4), 14-deoxy-14,15-dehydroandrographolide (5), and a new compound, 19-O-acetyl-14-deoxy-11,12-didehydroandrographolide (6a), significantly inhibited the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages (P < 0.05). The two most abundant compounds, 14-deoxy-11,12-didehydroandrographolide (7) and andrographolide (8), had less inhibitory activity but exerted greater inhibitory activity by hydrogenation, oxidation, or acetylation to become four derived compounds, 9, 10, 11, and 12. All of the compounds significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. Compounds 5, 11, and 12 exerted the strongest inhibitory effect on NF-kappaB-dependent transactivation in the RAW 264.7 cell, with IC(50) values of 2, 2.2, and 2.4 microg/mL, respectively, providing encouraging results for bioactive compound development.
    In vivo:
    Zhong Yao Cai. 2015 Jan;38(1):89-92.
    Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875]
    To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
    METHODS AND RESULTS:
    The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
    CONCLUSIONS:
    All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3523 mL 16.7616 mL 33.5233 mL 67.0466 mL 83.8082 mL
    5 mM 0.6705 mL 3.3523 mL 6.7047 mL 13.4093 mL 16.7616 mL
    10 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
    50 mM 0.067 mL 0.3352 mL 0.6705 mL 1.3409 mL 1.6762 mL
    100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-羟基-7-乙酰氧基-8-甲氧基黄酮; 5-Hydroxy-7-acetoxy-8-methoxyflavone CFN97535 95480-80-1 C18H14O6 = 326.3 5mg QQ客服:2932563308
    5,7-二羟基-8-甲氧基黄酮二乙酸酯; 5,7-Diacetoxy-8-methoxyflavone CFN98240 23246-80-2 C20H16O7 = 368.3 5mg QQ客服:2056216494
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮; Moslosooflavone CFN98475 3570-62-5 C17H14O5 = 298.3 20mg QQ客服:2159513211
    5,7,8-三甲氧基去甲汉黄芩素; Norwogonin 5,7,8-trimethyl ether CFN91074 23050-38-6 C18H16O5 = 312.3 10mg QQ客服:1413575084
    黄芩素; 黄芩苷元; Baicalein CFN98783 491-67-8 C15H10O5 = 270.2 20mg QQ客服:3257982914
    千层纸素A; Oroxylin A CFN98540 480-11-5 C16H12O5 = 284.26 20mg QQ客服:3257982914
    7-甲醚黄芩素; Negletein CFN91886 29550-13-8 C16H12O5 = 284.26 5mg QQ客服:2159513211
    荠苧黄酮; Mosloflavone CFN90893 740-33-0 C17H14O5 = 298.3 20mg QQ客服:3257982914
    6-羟基汉黄芩素; 6-Hydroxywogonin CFN95009 76844-70-7 C16H12O6 = 300.3 5mg QQ客服:2932563308
    5,7-二羟基-6,8-二甲氧基黄酮; 6-Methoxywogonin CFN98403 3162-45-6 C17H14O6 = 314.3 5mg QQ客服:2159513211

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