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    荠苧黄酮

    Mosloflavone

    荠苧黄酮
    产品编号 CFN90893
    CAS编号 740-33-0
    分子式 = 分子量 C17H14O5 = 298.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Mosla soochouensis Matsuda
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    荠苧黄酮 CFN90893 740-33-0 10mg QQ客服:1457312923
    荠苧黄酮 CFN90893 740-33-0 20mg QQ客服:1457312923
    荠苧黄酮 CFN90893 740-33-0 50mg QQ客服:1457312923
    荠苧黄酮 CFN90893 740-33-0 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Colorado State University (USA)
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  • Guangzhou Institutes of Biomedicine and Health (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • BMC Complement Altern Med.2016, 16:213
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Viruses.2017, 9(10)
  • Nutrients.2018, 11(1):E17
  • Phytochemistry2018, 15:83-92
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Srinagarind Medical Journal2019, 34(1)
  • Journal of Apiculture2019, 34(2):131-136
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • J Pharmaceut Biomed2020, 182:113110
  • J Ethnopharmacol.2020, 249:112396
  • Agronomy2020, 10(3),388.
  • UDC.2020, 19(4).
  • Molecules.2020, 25(18):4283.
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • Korean J Acupunct2020, 37:104-121
  • Heliyon2020, 6(6):e04337.
  • Indian J. of Experimental Bio.2020, 9(58).
  • Antioxidants (Basel).2020, 9(6):526.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Separations2021, 8(1), 1.
  • ...
  • 生物活性
    Description: Mosloflavanone is an antifungal and radical scavenging 2-hydroxyflavanone, it possesses strong anti-EV71 activity and decreased the formation of visible cytopathic effects, it also inhibits virus replication during the initial stage of virus infection, and inhibits viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; it shows dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases.
    Targets: TNF-α | IL-1β Receptor | NOS | Antifection
    In vitro:
    Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8.
    Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.[Pubmed: 27257010 ]
    Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of new antiviral compounds.
    METHODS AND RESULTS:
    In the present study, the anti-EV71 activity of norwogonin, oroxylin A, and mosloflavone from Scutellaria baicalensis Georgi was evaluated using a cytopathic effect (CPE) reduction method, which demonstrated that all three compounds possessed strong anti-EV71 activity and decreased the formation of visible CPEs. Norwogonin, oroxylin A, and mosloflavone also inhibited virus replication during the initial stage of virus infection, and they inhibited viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. However, ribavirin has a relatively weaker efficacy compared to the other drugs.
    CONCLUSIONS:
    Therefore, these findings provide important information that will aid in the utilization of norwogonin, oroxylin A, and mosloflavone for EV71 treatment.
    Nat Prod Res. 2013;27(23):2227-30.
    Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.[Pubmed: 23768253 ]

    METHODS AND RESULTS:
    Herein, we report the isolation and immunomodulatory activity of 11 phytoconstituents, viz. 7 flavonoids, 3 pentacyclic triterpenes and 1 phytosterol of an unexplored plant Actinocarya tibetica Benth. Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), mosloflavone (7) and negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.22, 0.71, 16.4 μM and 10.8, 7.8, 6.4 μM, respectively. These flavones also showed dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A. Molecular modelling studies revealed orientation and interactions of flavones 6-8 in the active site of TNF-α.
    CONCLUSIONS:
    These flavones can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases.
    In vivo:
    Zhong Yao Cai. 2015 Jan;38(1):89-92.
    Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875]
    To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
    METHODS AND RESULTS:
    The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
    CONCLUSIONS:
    All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3523 mL 16.7616 mL 33.5233 mL 67.0466 mL 83.8082 mL
    5 mM 0.6705 mL 3.3523 mL 6.7047 mL 13.4093 mL 16.7616 mL
    10 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
    50 mM 0.067 mL 0.3352 mL 0.6705 mL 1.3409 mL 1.6762 mL
    100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6,7-二羟基黄酮; 6,7-Dihydroxyflavone CFN70351 38183-04-9 C15H10O4 = 254.2 5mg QQ客服:1413575084
    7,8-二羟基黄酮; 7,8-Dihydroxyflavone CFN96512 38183-03-8 C15H10O4 = 254.24 20mg QQ客服:2932563308
    白杨素; Chrysin CFN98741 480-40-0 C15H10O4 = 254.2 20mg QQ客服:3257982914
    5-羟基-7-乙酰氧基黄酮; 5-Hydroxy-7-acetoxyflavone CFN97139 6674-40-4 C17H12O5 = 296.3 5mg QQ客服:1413575084
    5-乙酰氧基-7-羟基黄酮; 5-Acetoxy-7-hydroxyflavone CFN99409 132351-58-7 C17H12O5 = 296.3 5mg QQ客服:2056216494
    5,7-二乙酰氧基黄酮; 5,7-Diacetoxyflavone CFN97138 6665-78-7 C19H14O6 = 338.3 5mg QQ客服:1457312923
    柚木柯因; Tectochrysin CFN98840 520-28-5 C16H12O4 = 268.3 20mg QQ客服:2932563308
    柯因二甲醚; Chrysin dimethylether CFN90896 21392-57-4 C17H14O4 = 282.3 20mg QQ客服:1457312923
    去甲汉黄芩素; Norwogonin CFN92218 4443-09-8 C15H10O5 = 270.2 10mg QQ客服:2056216494
    汉黄芩素; Wogonin CFN97089 632-85-9 C16H12O5 = 284.3 20mg QQ客服:2159513211

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