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    7-甲醚黄芩素

    Negletein

    7-甲醚黄芩素
    产品编号 CFN91886
    CAS编号 29550-13-8
    分子式 = 分子量 C16H12O5 = 284.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Desmos chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-甲醚黄芩素 CFN91886 29550-13-8 1mg QQ客服:3257982914
    7-甲醚黄芩素 CFN91886 29550-13-8 5mg QQ客服:3257982914
    7-甲醚黄芩素 CFN91886 29550-13-8 10mg QQ客服:3257982914
    7-甲醚黄芩素 CFN91886 29550-13-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade de Franca (Brazil)
  • Texas A&M University (USA)
  • Harvard University (USA)
  • University of Pretoria (South Africa)
  • University of Minnesota (USA)
  • Calcutta University (India)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Cornell University (USA)
  • University of Bordeaux (France)
  • University of Auckland (New Zealand)
  • Regional Crop Research Institute (Korea)
  • Universitas islam negeri Jakarta (Indonesia)
  • Georgia Institute of Technology (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J-STAGE2015, 249-255
  • J Med Food.2016, 19(12):1155-1165
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Molecules.2017, 22(2)
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Phytochemistry2018, 15:83-92
  • Journal of functional foods2018, 171-182
  • Life Sci.2018, 209:498-506
  • Molecules.2018, 23(7):E1817
  • Plant Cell Physiol.2018, 59(1):128-141
  • Arch Biochem Biophys.2018, 644:93-99
  • Cell Death Dis.2019, 10(12):882
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Environ Toxicol.2019, 34(4):513-520.
  • New Journal of Chemistry2019, 43:12538-12547
  • Antioxidants (Basel).2020, 9(2):E99
  • Agronomy2020, 10(10),1489
  • Crystals2020, 10(3), 206.
  • Nutrients.2020, 12(11):3448.
  • UDC.2020, 19(4).
  • Cell Rep.2020, 32(11):108158.
  • Eur Endod J.2020, 5(1):23-27.
  • ...
  • 生物活性
    Description: Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β, it also shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells, it has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Negletein also shows significant antimicrobial activity.
    Targets: TNF-α | NOS | IL Receptor | cAMP | Akt | ERK | Nrf2 | Antifection | ROS | NF-kB
    In vitro:
    Nat Prod Res. 2016 Sep;30(17):2002-6.
    Antimicrobial flavonoids isolated from Indian medicinal plant Scutellaria oblonga inhibit biofilms formed by common food pathogens.[Pubmed: 26508034 ]
    Scutellaria oblonga Benth., a hitherto phytochemically unexplored Indian medicinal folklore plant was extracted with acetone and subjected to chromatography to yield nine flavonoids, for the first time from this plant.
    METHODS AND RESULTS:
    Antimicrobial assays were performed against 11 foodborne pathogens, and three molecules (Techtochrysin, Negletein and Quercitin-3-glucoside) depicted significant activity. These molecules were assessed for their rate of antibacterial action using time-kill curves which depicted complete inhibition of most of the bacteria within 12-16 h. The significant biofilm-reducing capability exhibited by these three molecules formed a significant finding of the current study. In most of the experiments, a 90-95% reduction in biofilms was observed.
    CONCLUSIONS:
    Thus, flavonoids as natural molecules from S. oblonga could be further researched to be used as potent antimicrobial and antibiofilm agents.
    Nat Prod Res. 2013;27(23):2227-30.
    Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.[Pubmed: 23768253]

    METHODS AND RESULTS:
    Herein, we report the isolation and immunomodulatory activity of 11 phytoconstituents, viz. 7 flavonoids, 3 pentacyclic triterpenes and 1 phytosterol of an unexplored plant Actinocarya tibetica Benth. Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), mosloflavone (7) and Negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.22, 0.71, 16.4 μM and 10.8, 7.8, 6.4 μM, respectively. These flavones also showed dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A. Molecular modelling studies revealed orientation and interactions of flavones 6-8 in the active site of TNF-α.
    CONCLUSIONS:
    These flavones can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases.
    Arch Pharm Res. 2005 Dec;28(12):1345-9.
    Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis.[Pubmed: 16392667]

    METHODS AND RESULTS:
    Six phenolic constituents, 2-methoxybenzyl benzoate (1), Negletein (2), 2',3'-dihydroxy-4',6'-dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data.
    CONCLUSIONS:
    Of these constituents, compounds 2 (IC50: 3.89 +/- 0.39 microM) and 3 (IC50: 9.77 +/- 0.26 microM) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (IC50: 28.4 +/- 2.62 microM) exhibited moderate inhibitory activity.
    In vivo:
    Zhong Yao Cai. 2015 Jan;38(1):89-92.
    Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875]
    To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
    METHODS AND RESULTS:
    The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), Negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
    CONCLUSIONS:
    All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5179 mL 17.5895 mL 35.1791 mL 70.3581 mL 87.9477 mL
    5 mM 0.7036 mL 3.5179 mL 7.0358 mL 14.0716 mL 17.5895 mL
    10 mM 0.3518 mL 1.759 mL 3.5179 mL 7.0358 mL 8.7948 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4072 mL 1.759 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二羟基-8-甲氧基黄酮二乙酸酯; 5,7-Diacetoxy-8-methoxyflavone CFN98240 23246-80-2 C20H16O7 = 368.3 5mg QQ客服:1457312923
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮; Moslosooflavone CFN98475 3570-62-5 C17H14O5 = 298.3 20mg QQ客服:3257982914
    5,7,8-三甲氧基去甲汉黄芩素; Norwogonin 5,7,8-trimethyl ether CFN91074 23050-38-6 C18H16O5 = 312.3 10mg QQ客服:3257982914
    黄芩素; 黄芩苷元; Baicalein CFN98783 491-67-8 C15H10O5 = 270.2 20mg QQ客服:1413575084
    千层纸素A; Oroxylin A CFN98540 480-11-5 C16H12O5 = 284.26 20mg QQ客服:1457312923
    7-甲醚黄芩素; Negletein CFN91886 29550-13-8 C16H12O5 = 284.26 5mg QQ客服:1413575084
    荠苧黄酮; Mosloflavone CFN90893 740-33-0 C17H14O5 = 298.3 20mg QQ客服:2932563308
    6-羟基汉黄芩素; 6-Hydroxywogonin CFN95009 76844-70-7 C16H12O6 = 300.3 5mg QQ客服:3257982914
    5,7-二羟基-6,8-二甲氧基黄酮; 6-Methoxywogonin CFN98403 3162-45-6 C17H14O6 = 314.3 5mg QQ客服:2056216494
    6,7-二羟基黄酮; 6,7-Dihydroxyflavone CFN70351 38183-04-9 C15H10O4 = 254.2 5mg QQ客服:2932563308

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