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  • 白杨素

    Chrysin

    白杨素
    产品编号 CFN98741
    CAS编号 480-40-0
    分子式 = 分子量 C15H10O4 = 254.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The barks of Oroxylum indicum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白杨素 CFN98741 480-40-0 10mg QQ客服:1148253675
    白杨素 CFN98741 480-40-0 20mg QQ客服:1148253675
    白杨素 CFN98741 480-40-0 50mg QQ客服:1148253675
    白杨素 CFN98741 480-40-0 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universidad Miguel Hernández (Spain)
  • National Chung Hsing University (Taiwan)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Seoul National University (Korea)
  • National Research Council of Canada (Canada)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Perugia (Italy)
  • Imperial College London (United Kingdom)
  • Wroclaw Medical University (Poland)
  • University of Hull (United Kingdom)
  • Colorado State University (USA)
  • University of Brasilia (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Industrial Food Engineering2015, 19(4):408-413
  • PLoS One.2017, 12(3):e0173585
  • J. of The Korean Society of Food Culture2017, 144-149
  • Srinagarind Medical Journal2017, 32(1)
  • Nat Prod Communications2018, 10.1177
  • Molecules.2018, 23(7):E1659
  • BMB Rep.2018, 51(5):249-254
  • Planta Med.2018, 84(15):1101-1109
  • Bio-protocol2018, 9(14):e3301
  • Phytother Res.2019, 10.1002
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Food Res Int.2019, 123:125-134
  • Exp Ther Med.2019, 18(6):4388-4396
  • Med Sci Monit.2019, 25:9499-9508
  • Journal of Oil Palm Research2019, 31(2):238-247
  • FASEB J.2019, 33(2):2026-2036
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Oncol Rep.2019, 41(4):2453-2463
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • ...
  • 生物活性
    Description: Chrysin, a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant , anti-inflammation, anti-cancer, hepatoprotective, and anti-oxidation properties. Chrysin induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells; it prevented the development of DN in HFD/STZ-induced type 2 diabetic rats through anti-inflammatory effects in the kidney by specifically targeting the TNF-α pathway.
    Targets: NOS | COX | TNF-α | PGE | IL Receptor | PI3K | Akt | Caspase | NF-kB | TGF-β/Smad
    In vivo:
    Toxicol Lett. 2013 Feb 4;216(2-3):146-58.
    Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.[Pubmed: 23194824]
    Flavonoid family is a rich source of polyphenolic compounds and hence possess strong antioxidant and anti inflammatory properties. The aim of this study was to determine the efficacy of chrysin; a bio-active flavonoid as an anticancer agent.
    METHODS AND RESULTS:
    Renal cancer was initiated by single intraperitoneal (i.p.) injection of N-nitrosodiethylamine (DEN 200 mg/kg BW body weight) and promoted by twice weekly administration of ferric nitrilotriacetate (Fe-NTA) 9 mg Fe/kg BW for 16 wk. In the present study, we report the chemopreventive effects of chrysin against (Fe-NTA) induced renal oxidative stress, inflammation, hyperproliferative response, and two-stage renal carcinogenesis. To ascertain the molecular mechanism implicated in the antitumor promoting activity of chrysin, its effect was investigated on markers of tumor promotion and inflammation: ornithine decarboxylase (ODC) activity, proliferating cell nuclear antigen (PCNA), inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) expression, and on levels of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and prostaglandin E(2) (PGE(2)). Pretreatment of animals with chrysin at both doses (20 and 40 mg/kg body weight) markedly inhibited all. Further, Fe-NTA enhances renal lipid peroxidation, with concomitant reduction in reduced glutathione content (GSH), antioxidant enzymes, and phase II metabolizing enzymes. It induces serum toxicity markers, viz., blood urea nitrogen (BUN), creatinine and lactate dehydrogenase (LDH). Prophylactic treatment of animals with chrysin before the administration of Fe-NTA was effective in modulating oxidative and renal injury markers and resulted in the diminution of Fe-NTA mediated injury.
    CONCLUSIONS:
    These results suggest chrysin as an effective chemopreventive agent having the capability to obstruct DEN initiated and Fe-NTA promoted renal cancer in the rat model.
    Int J Oncol. 2015 Apr;46(4):1835-43.
    Chrysin inhibits cell invasion by inhibition of Recepteur d'origine Nantais via suppressing early growth response-1 and NF-κB transcription factor activities in gastric cancer cells.[Pubmed: 25625479]
    Cell invasion is one of crucial reasons for cancer metastasis and malignancy. Recepteur d'origine Nantais (RON) has been reported to play an important role in the cancer cell invasion process. High accumulation and activation of RON has been implicated in gastric adenocarcinoma AGS cells. Chrysin is a naturally occurring phytochemical, a type of flavonoid, which has been reported to suppress tumor metastasis. However, the effects of chrysin on RON expression in gastric cancer are not well studied.
    METHODS AND RESULTS:
    In the present study, we examined whether chrysin affects RON expression in gastric cancer, and if so, its underlying mechanism. We examined the effect of chrysin on RON expression and activity, via RT-PCR, promoter study, and western blotting in human gastric cancer AGS cells. Chrysin significantly inhibited endogenous and inducible RON expression in a dose-dependent manner. After demonstrating that Egr-1 and NF-κB are the critically required transcription factors for RON expression, we discovered that chrysin suppressed Egr-1 and NF-κB transcription factor activities. Additionally, the phorbol-12-myristate-13-acetate- (PMA) induced cell invasion was partially abrogated by chrysin and an RON antibody.
    CONCLUSIONS:
    Our results suggest that chrysin has anticancer effects at least by suppressing RON expression through blocking Egr-1 and NF-κB in gastric cancer AGS cells.
    Pharmacol Biochem Behav. 1994 Jan;47(1):1-4.
    Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea.[Pubmed: 7906886]
    The pharmacological effects of 5,7-dihydroxyflavone (chrysin), a naturally occurring monoflavonoid that displaces [3H]flunitrazepam binding to the central benzodiazepine (BDZ) receptors, were examined in mice.
    METHODS AND RESULTS:
    In the elevated plus-maze test of anxiety, diazepam (DZ, 0.3-0.6 mg/kg) or chrysin (1 mg/kg) induced increases in the number of entries into the open arms and in the time spent on the open arms, consistent with an anxiolytic action of both compounds. The effects of chrysin on the elevated plus-maze was abolished by pretreatment with the specific BDZ receptor antagonist Ro 15-1788 (3 mg/kg). In the holeboard, diazepam (1 mg/kg) and chrysin (3 mg/kg) increased the time spent head-dipping. In contrast, high doses of DZ (6 mg/kg) but not of chrysin produced a decrease in the number of head dips and in the time spent head-dipping. In the horizontal wire test, diazepam (6 mg/kg) had a myorelaxant action. In contrast, chrysin (0.6-30 mg/kg) produced no effects in this test.
    CONCLUSIONS:
    These data suggest that chrysin possesses anxiolytic actions without inducing sedation and muscle relaxation. We postulate that this natural monoflavonoid is a partial agonist of the central BDZ receptors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
    5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
    10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
    50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
    100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二羟基-8-甲氧基黄酮二乙酸酯; 5,7-Diacetoxy-8-methoxyflavone CFN98240 23246-80-2 C20H16O7 = 368.3 5mg QQ客服:3257982914
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮; Moslosooflavone CFN98475 3570-62-5 C17H14O5 = 298.3 20mg QQ客服:1148253675
    5,7,8-三甲氧基去甲汉黄芩素; Norwogonin 5,7,8-trimethyl ether CFN91074 23050-38-6 C18H16O5 = 312.3 10mg QQ客服:215959384
    黄芩素; 黄芩苷元; Baicalein CFN98783 491-67-8 C15H10O5 = 270.2 20mg QQ客服:215959384
    千层纸素A; Oroxylin A CFN98540 480-11-5 C16H12O5 = 284.26 20mg QQ客服:2159513211
    7-甲醚黄芩素; Negletein CFN91886 29550-13-8 C16H12O5 = 284.26 5mg QQ客服:2159513211
    荠苧黄酮; Mosloflavone CFN90893 740-33-0 C17H14O5 = 298.3 20mg QQ客服:215959384
    6-羟基汉黄芩素; 6-Hydroxywogonin CFN95009 76844-70-7 C16H12O6 = 300.3 5mg QQ客服:215959384
    5,7-二羟基-6,8-二甲氧基黄酮; 6-Methoxywogonin CFN98403 3162-45-6 C17H14O6 = 314.3 5mg QQ客服:1413575084
    6,7-二羟基黄酮; 6,7-Dihydroxyflavone CFN70351 38183-04-9 C15H10O4 = 254.2 5mg QQ客服:215959384

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