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  • 8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素

    Cedrelopsin

    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素
    产品编号 CFN89410
    CAS编号 19397-28-5
    分子式 = 分子量 C15H16O4 = 260.28
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The trunk barks of Cedrelopsis grevei.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素 CFN89410 19397-28-5 1mg QQ客服:1413575084
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素 CFN89410 19397-28-5 5mg QQ客服:1413575084
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素 CFN89410 19397-28-5 10mg QQ客服:1413575084
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素 CFN89410 19397-28-5 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Lodz University of Technology (Poland)
  • University of Vigo (Spain)
  • University of Helsinki (Finland)
  • Chinese University of Hong Kong (China)
  • Regional Crop Research Institute (Korea)
  • National Chung Hsing University (Taiwan)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Indonesia (Indonesia)
  • Donald Danforth Plant Science Center (USA)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Universiti Sains Malaysia (Malaysia)
  • Texas A&M University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ind Crops Prod.2014, 62:173-178
  • Molecules.2015, 20(10):19172-88
  • Phytomedicine.2015, 22(11):1027-36
  • Am J Chin Med.2016, 44(8):1719-1735
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Int J Mol Sci.2017, 18(5)
  • J Ethnopharmacol.2017, 198:87-90
  • Molecules.2017, 22(11)
  • Nutrients.2018, 10(7)
  • Nat Prod Sci.2018, 24(3):206
  • Korean J Environ Agric.2018, 37(4):260-267
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Front Neurosci.2019, 13:1091
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • J Ethnopharmacol.2019, 235:406-414
  • Molecules.2019, 24(22):E4022
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Phytomedicine.2019, 65:153089
  • Int Immunopharmacol.2019, 71:22-31
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • J Pharmaceut Biomed2020, 182:113110
  • J Sep Sci.2020, 201901140
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Cedrelopsin shows significant inhibition against A549 cells with IC50 values of 3.6-5.9 ug/mL.
    In vitro:
    Medicinal Chemistry Research, 2016, 25(3):466-472.
    Cytotoxic constituents of Oldenlandia umbellata and isolation of a new symmetrical coumarin dimer.[Reference: WebLink]
    Chemical investigation of HUM-E and HUM-B resulted in the isolation of a novel symmetrical coumarin dimer named oledicoumarin (1), together with eleven known compounds, hedyotiscone B (2), Cedrelopsin (3), pheophorbide A methyl ester (4), deacetyl asperuloside (5), scandoside methyl ester (6), asperulosidic acid (7), scandoside (8), nicotinic acid (9), 6α-hydroxy geniposide (10) anthragallol 1,2-dimethyl ether (11) and anthragallol 1,3-dimethyl ether (12).
    METHODS AND RESULTS:
    All compounds were isolated for the first time from O. umbellata except anthragallols. This is the foremost report exploring the presence of coumarin derivatives in O. umbellata. Testing of cytotoxicity of isolated constituents revealed that compounds 3, 4, 11 and 12 showed significant inhibition against A549 cells with IC50 values of 3.6–5.9 μg/mL. Compounds 4, 11 and 12 showed marked inhibitory effect against MDA-MB-231 cells (IC50 3.6–9.1 μg/mL). Compounds 4 (IC50 1.7 μg/mL) and 7 (IC50 6.1 μg/mL) were highly active against HT-29 cells.
    CONCLUSIONS:
    In summary, the less polar fraction of O. umbellata and its constituents were found to be cytotoxic.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.842 mL 19.2101 mL 38.4202 mL 76.8403 mL 96.0504 mL
    5 mM 0.7684 mL 3.842 mL 7.684 mL 15.3681 mL 19.2101 mL
    10 mM 0.3842 mL 1.921 mL 3.842 mL 7.684 mL 9.605 mL
    50 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.5368 mL 1.921 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7684 mL 0.9605 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素; Cedrelopsin CFN89410 19397-28-5 C15H16O4 = 260.28 5mg QQ客服:3257982914
    O-Methylcedrelopsin; O-Methylcedrelopsin CFN92731 72916-61-1 C16H18O4 = 274.3 5mg QQ客服:1413575084
    月橘香豆精; 九里香内酯; Coumurrayin CFN99811 17245-25-9 C16H18O4 = 274.3 5mg QQ客服:1148253675
    (S)-8-[(3,3-二甲基环氧乙烷基)甲基]-5,7-二甲氧基-2H-1-苯并吡喃-2-酮; Sibiricin CFN97531 95188-34-4 C16H18O5 = 290.3 5mg QQ客服:1148253675
    九里香甲素; Isomexoticin CFN97454 88585-86-8 C16H20O6 = 308.3 5mg QQ客服:215959384
    九里香醇; Murraol CFN99097 109741-38-0 C15H16O4 = 260.3 5mg QQ客服:2159513211
    异味决明内酯醇; Casegravol CFN97693 74474-76-3 C15H16O5 = 276.29 5mg QQ客服:2159513211
    蛇床子素; Osthol CFN98765 484-12-8 C15H16O3 = 244.3 20mg QQ客服:2932563308
    橙皮内酯; Meranzin CFN98249 23971-42-8 C15H16O4 = 260.3 5mg QQ客服:1148253675
    水合蛇床子素; Osthol hydrate CFN90848 69219-24-5 C15H18O4 = 262.3 10mg QQ客服:1148253675

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