• 中药标准品生产商,产品定制服务
  • 厚朴醛B

    Magnaldehyde B

    厚朴醛B
    产品编号 CFN95075
    CAS编号 92829-72-6
    分子式 = 分子量 C18H16O3 = 280.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The barks of Magnolia officinalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    厚朴醛B CFN95075 92829-72-6 1mg QQ客服:3257982914
    厚朴醛B CFN95075 92829-72-6 5mg QQ客服:3257982914
    厚朴醛B CFN95075 92829-72-6 10mg QQ客服:3257982914
    厚朴醛B CFN95075 92829-72-6 20mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Subang Jaya Medical Centre (Malaysia)
  • Universiti Malaysia Pahang (Malaysia)
  • Universidade do Porto (Portugal)
  • University of Otago (New Zealand)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Srinakharinwirot University (Thailand)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Wollongong (Australia)
  • John Innes Centre (United Kingdom)
  • Northeast Normal University Changchun (China)
  • The Ohio State University (USA)
  • Seoul National University (Korea)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Breast Cancer.2015, 18(2):112-118
  • Arch Pharm Res.2015, 38(6):1080-9
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • J Med Food.2016, 19(12):1155-1165
  • Phytother Res.2016, 30(12):2020-2026
  • Mol Immunol. 2016, 78:121-132
  • Int J Anal Chem.2017, 2017:1254721
  • Molecules.2017, 22(11)
  • Food Chem.2017, 228:301-314
  • Universidade Estadual Paulista2017, 42785
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Korean j.of Pharm.2017, 70-76
  • Journal of functional foods2018, 171-182
  • Molecules.2018, 23(11):E2837
  • Mol Cells.2018, 41(8):771-780
  • Phytomedicine.2018, 47:48-57
  • Front Cell Infect Microbiol.2018, 8:292
  • Front Immunol.2018, 9:2655
  • Chemistry of Plant Materials.2019, 129-136
  • Int J Mol Sci.2019, 20(21):E5488
  • Molecules.2019, 24(2):329
  • J Ethnopharmacol.2019, 241:112025
  • Food Research International2020, 108987
  • ...
  • 生物活性
    Description: Magnaldehyde B is a natural lipase inhibitor(IC50= 96.96 uM). Magnaldehyde B can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.
    In vitro:
    J Chromatogr A. 2015 May 1;1392:20-7.
    Fabrication of enzyme-immobilized halloysite nanotubes for affinity enrichment of lipase inhibitors from complex mixtures.[Pubmed: 25798866 ]
    Lipase is the key enzyme for catalyzing triglyceride hydrolysis in vivo, and lipase inhibitors have been used in the management of obesity.
    METHODS AND RESULTS:
    We present the first report on the use of lipase-adsorbed halloysite nanotubes as an efficient medium for the selective enrichment of lipase inhibitors from natural products. A simple and rapid approach was proposed to fabricate lipase-adsorbed nanotubes through electrostatic interaction. Results showed that more than 85% lipase was adsorbed into nanotubes in 90 min, and approximately 80% of the catalytic activity was maintained compared with free lipase. The specificity and reproducibility of the proposed approach were validated by screening a known lipase inhibitor (i.e., orlistat) from a mixture that contains active and inactive compounds. Moreover, we applied this approach with high performance liquid chromatography-mass spectrometry technique to screen lipase inhibitors from the Magnoliae cortex extract, a medicinal plant used for treating obesity. Two novel biphenyl-type natural lipase inhibitors magnotriol A and magnaldehyde B were identified, and their IC50 values were determined as 213.03 and 96.96 μM, respectively.
    CONCLUSIONS:
    The ligand-enzyme interactions of magnaldehyde B were further investigated by molecular docking. Our findings proved that enzyme-adsorbed nanotube could be used as a feasible and selective affinity medium for the rapid screening of enzyme inhibitors from complex mixtures.
    Phytother Res. 2013 Sep;27(9):1419-22.
    Apoptosis-inducing and antitumor activity of neolignans isolated from Magnolia officinalis in HeLa cancer cells.[Pubmed: 23192855 ]
    Two neolignans, 4'-methoxymagndialdehyde (1) and magnaldehyde B (2), were isolated from the stem bark of Magnolia officinalis (Magnoliaceae), evaluated for apoptosis-inducing effects in human cervical epitheloid carcinoma HeLa cells.
    METHODS AND RESULTS:
    The apoptosis-inducing activity of compounds 1 and 2 were assessed by DNA content using flow cytometric analysis. In the immunoblotting analysis, the treatment with 1 and 2 resulted in the cleavage of procaspase-8 and -3 and poly(ADP-ribose)polymerase into active forms. In addition, in vivo, the administration of 2 to Lewis lung carcinoma-inoculated mice evidenced a significant inhibition of tumor growth (volume) with reduction of 28.7% at concentration of 20 mg/kg, as compared with the control mice.
    CONCLUSIONS:
    These findings suggest that 2 can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5676 mL 17.838 mL 35.6761 mL 71.3521 mL 89.1902 mL
    5 mM 0.7135 mL 3.5676 mL 7.1352 mL 14.2704 mL 17.838 mL
    10 mM 0.3568 mL 1.7838 mL 3.5676 mL 7.1352 mL 8.919 mL
    50 mM 0.0714 mL 0.3568 mL 0.7135 mL 1.427 mL 1.7838 mL
    100 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.7135 mL 0.8919 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    四氢厚朴酚; Tetrahydromagnolol CFN91033 20601-85-8 C18H22O2 = 270.4 20mg QQ客服:1148253675
    厚朴酚; Magnolol CFN98872 528-43-8 C18H18O2 = 266.3 20mg QQ客服:1148253675
    和厚朴酚; Honokiol CFN99902 35354-74-6 C18H18O2 = 266.34 20mg QQ客服:3257982914
    异红花八角醇; Isodunnianol CFN99449 139726-30-0 C27H26O3 = 398.5 5mg QQ客服:2932563308
    红花八角醇; Dunnianol CFN99448 139726-29-7 C27H26O3 = 398.5 5mg QQ客服:1413575084
    Simonsinol; Simonsinol CFN99661 155709-40-3 C27H26O3 = 398.5 5mg QQ客服:1148253675
    木兰素; Magnolianin CFN96079 147663-91-0 C54H50O8 = 827.0 5mg QQ客服:1413575084
    厚朴木酚素A; Magnolignan A CFN96188 93673-81-5 C18H20O4 = 300.4 5mg QQ客服:2159513211
    厚朴木酚素C; Magnolignan C CFN96189 93697-42-8 C18H20O4 = 300.4 5mg QQ客服:2159513211
    (1S,2S)-threo-Honokitriol; (1S,2S)-threo-Honokitriol CFN95076 1099687-80-5 C18H20O5 = 316.4 5mg QQ客服:2932563308

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产