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  • 石松胺

    Lycopsamine

    石松胺
    产品编号 CFN00287
    CAS编号 10285-07-1
    分子式 = 分子量 C15H25NO5 = 299.37
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The herbs of Eupatorium maculatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    石松胺 CFN00287 10285-07-1 1mg QQ客服:3257982914
    石松胺 CFN00287 10285-07-1 5mg QQ客服:3257982914
    石松胺 CFN00287 10285-07-1 10mg QQ客服:3257982914
    石松胺 CFN00287 10285-07-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Santa Catarina (Brazil)
  • University of Liège (Belgium)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Korea Food Research Institute(KFRI) (Korea)
  • Indian Institute of Science (India)
  • Universitas Airlangga (Indonesia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • The Ohio State University (USA)
  • Chungnam National University (Korea)
  • Macau University of Science and Technology (China)
  • University of Medicine and Pharmacy (Romania)
  • Harvard University (USA)
  • Tohoku University (Japan)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2015, 16(8):18396-411
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • J Ethnopharmacol.2017, 198:91-97
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Front Pharmacol.2017, 8:205
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • J Sep Sci.2018, 41(11):2488-2497
  • BMB Rep.2018, 51(5):249-254
  • Pharmacol Rep.2018, 70(6):1195-1201
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Food Res Int.2019, 123:125-134
  • BMC Complement Altern Med.2019, 19(1):325
  • Molecules.2019, 24(6):E1155
  • Molecules.2019, 24(7):E1290
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Anal Sci.2019, 35(12):1317-1325
  • Appl Biol Chem2019, 62:46
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Plant Cell Tiss Org2020, 1-16
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Acta Pharm. 2014 Dec;64(4):503-8.
    TLC densitometric method for screening of lycopsamine in comfrey root (Symphytum officinale L.) extracts using retrorsine as a reference compound.[Pubmed: 25531790]
    Due to severe toxicity of pyrrolizidine alkaloids, their quantification in medicinal products is very important. The idea of this research was to use retrorsine as a surrogate reference compound instead of Lycopsamine reference or Lycopsamine isolated from comfrey.
    METHODS AND RESULTS:
    A method for the analysis of Lycopsamine in extracts of comfrey roots was developed and validated, employing thin layer chromatography, derivatisation with Dann-Mattocks reagent followed by densitometric analysis. The new method showed linearity within 0.70 to 7.0 μg of Lycopsamine per application of 10 μL of a solution. It has also been proven to be specific and precise (repeatability RSD 2-4 % within the plate).
    CONCLUSIONS:
    The method was successfully employed for quantification of Lycopsamine in comfrey root and comfrey root medicinal products such as ointments.
    In vivo:
    J Appl Toxicol. 2016 May;36(5):716-25.
    The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus).[Pubmed: 26177929]
    Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic, genotoxic and carcinogenic. Consequently, regulatory agencies and international health organizations have recommended comfrey be used for external use only. However, in many locations comfrey continues to be ingested as a tisane or as a leafy vegetable.
    METHODS AND RESULTS:
    The objective of this work was to compare the toxicity of a crude, reduced comfrey alkaloid extract to purified lycopsamine and intermedine that are major constituents of S. officinale. Male, California White chicks were orally exposed to daily doses of 0.04, 0.13, 0.26, 0.52 and 1.04 mmol lycopsamine, intermedine or reduced comfrey extract per kg bodyweight (BW) for 10 days. After another 7 days chicks were euthanized. Based on clinical signs of poisoning, serum biochemistry, and histopathological analysis the reduced comfrey extract was more toxic than lycopsamine and intermedine.
    CONCLUSIONS:
    This work suggests a greater than additive effect of the individual alkaloids and/or a more potent toxicity of the acetylated derivatives in the reduced comfrey extract. It also suggests that safety recommendations based on purified compounds may underestimate the potential toxicity of comfrey.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3403 mL 16.7017 mL 33.4035 mL 66.807 mL 83.5087 mL
    5 mM 0.6681 mL 3.3403 mL 6.6807 mL 13.3614 mL 16.7017 mL
    10 mM 0.334 mL 1.6702 mL 3.3403 mL 6.6807 mL 8.3509 mL
    50 mM 0.0668 mL 0.334 mL 0.6681 mL 1.3361 mL 1.6702 mL
    100 mM 0.0334 mL 0.167 mL 0.334 mL 0.6681 mL 0.8351 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Petasinoside; Petasinoside CFN00277 70474-34-9 C28H37NO9 = 531.60 5mg QQ客服:1148253675
    Thesinine; Thesinine CFN00278 488-02-8 C17H21NO3 = 287.36 5mg QQ客服:215959384
    Ehretinine; Ehretinine CFN00282 76231-29-3 C16H21NO3 = 275.35 5mg QQ客服:215959384
    大尾摇碱,印度天芥莱碱; Indicine CFN00283 480-82-0 C15H25NO5 = 299.36 5mg QQ客服:215959384
    大尾摇碱-N-氧化物; Indicine N-oxide CFN00284 41708-76-3 C15H25NO6 = 315.37 5mg QQ客服:3257982914
    印美定; Intermedine CFN00285 10285-06-0 C15H25NO5 = 299.36 5mg QQ客服:1413575084
    印美定N-氧化物; Intermedine N-oxide CFN00459 95462-14-9 C15H25NO6 = 315.4 5mg QQ客服:2932563308
    7-Acetylintermedine; 7-Acetylintermedine CFN00286 74243-01-9 C17H27NO6 = 341.40 5mg QQ客服:215959384
    石松胺; Lycopsamine CFN00287 10285-07-1 C15H25NO5 = 299.37 5mg QQ客服:215959384
    7-乙酰基印美定; 7-Acetyllycopsamine CFN00288 73544-48-6 C17H27NO6 = 341.40 5mg QQ客服:215959384

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