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  • 7-O-Acetylintermedine N-oxide

    • 7-O-Acetylintermedine N-oxide

    7-O-Acetylintermedine N-oxide

    7-O-Acetylintermedine N-oxide
    		产品编号 CFN00518
    CAS编号 685132-59-6
    分子式 = 分子量 C17H27NO7 = 357.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Echium pininana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-O-Acetylintermedine N-oxide CFN00518 685132-59-6 1mg QQ客服：215959384
    7-O-Acetylintermedine N-oxide CFN00518 685132-59-6 5mg QQ客服：215959384
    7-O-Acetylintermedine N-oxide CFN00518 685132-59-6 10mg QQ客服：215959384
    7-O-Acetylintermedine N-oxide CFN00518 685132-59-6 20mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Analytical sci. & Tech2016, 186-193
  • Phytother Res.2022, 35844057.
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • BMC Complement Altern Med.2018, 18(1):221
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Sci Rep.2023, 13(1):13610.
  • Processes2022, 10(10), 2008.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Phytomedicine.2018, 41:62-66
  • Plant Foods Hum Nutr.2020, 10.1007
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • J Ethnopharmacol.2018, 210:88-94
  • Separation Science Plus2022, sscp.202200048.
  • Int J Mol Sci.2020, 21(9):3239.
  • Preprints2022, 2022030063.
  • Int. J of Herbal Med.2023, 11(1): 06-14
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Molecules.2021, 26(12):3652.
  • J Pharm Pharmacol.2022, rgac033.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • ...
    • 生物活性
    Description: 7-O-Acetylintermedine-N-oxide is a pyrrolizidine alkaloid isolated from Symphytum officinale. Pyrrolizidine alkaloids have adverse health effects and were classified as genotoxic, carcinogen and hepatotoxic.
    In vivo:
    EFSA Journal 2011;9(11):2406.
    Scientific Opinion on Pyrrolizidine alkaloids in food and feed[Reference: WebLink]
    The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on pyrrolizidine alkaloids (PA) in food and feed. PAs are toxins exclusively biosynthesised by plants. To date, approximately 600 different PAs are known. Results for 13,280 bulk honey and 1324 retail honey samples were provided to EFSA by one Member State and 351 feed samples were provided by a second Member State. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) performed estimates of both acute and chronic exposure to PAs through honey for three different age groups. Although there might be other sources of PA exposure, due to lack of data the CONTAM Panel was not able to quantify dietary exposure from food other than honey. A number of PAs were identified as being of particular importance for food and feed. Based on the present knowledge of metabolism, activation, DNA adduct-formation, genotoxicity and carcinogenicity, the CONTAM Panel concluded that 1,2-unsaturated PAs may act as genotoxic carcinogens in humans. Therefore, the CONTAM Panel decided to apply the Margin of Exposure (MOE) approach. A benchmark dose lower confidence limit for a 10 % excess cancer risk (BMDL10) of 70 μg/kg b.w. per day for induction of liver haemangiosarcomas by lasiocarpine in male rats was calculated as the reference point for comparison with the estimated dietary exposure. The CONTAM Panel concluded that there is a possible health concern for those toddlers and children who are high consumers of honey. There is generally a low risk of PA poisoning in livestock and companion animals in the EU as most PA poisonings reported recently are due to accidental exposure.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.798 mL 13.9899 mL 27.9799 mL 55.9597 mL 69.9496 mL
    5 mM 0.5596 mL 2.798 mL 5.596 mL 11.1919 mL 13.9899 mL
    10 mM 0.2798 mL 1.399 mL 2.798 mL 5.596 mL 6.995 mL
    50 mM 0.056 mL 0.2798 mL 0.5596 mL 1.1192 mL 1.399 mL
    100 mM 0.028 mL 0.1399 mL 0.2798 mL 0.5596 mL 0.6995 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    印美定N-氧化物; Intermedine N-oxide CFN00459 95462-14-9 C15H25NO6 = 315.4 5mg QQ客服：1413575084
    7-Acetylintermedine; 7-Acetylintermedine CFN00286 74243-01-9 C17H27NO6 = 341.40 5mg QQ客服：3257982914
    7-O-Acetylintermedine N-oxide; 7-O-Acetylintermedine N-oxide CFN00518 685132-59-6 C17H27NO7 = 357.4 5mg QQ客服：2159513211
    石松胺; Lycopsamine CFN00287 10285-07-1 C15H25NO5 = 299.37 5mg QQ客服：2056216494
    7-乙酰基印美定; 7-Acetyllycopsamine CFN00288 73544-48-6 C17H27NO6 = 341.40 5mg QQ客服：1457312923
    Petasinoside; Petasinoside CFN00277 70474-34-9 C28H37NO9 = 531.60 5mg QQ客服：2056216494
    Thesinine; Thesinine CFN00278 488-02-8 C17H21NO3 = 287.36 5mg QQ客服：215959384
    Ehretinine; Ehretinine CFN00282 76231-29-3 C16H21NO3 = 275.35 5mg QQ客服：1457312923
    大尾摇碱，印度天芥莱碱; Indicine CFN00283 480-82-0 C15H25NO5 = 299.36 5mg QQ客服：1413575084
    大尾摇碱-N-氧化物; Indicine N-oxide CFN00284 41708-76-3 C15H25NO6 = 315.37 5mg QQ客服：215959384

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