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    Intermedine

    印美定
    产品编号 CFN00285
    CAS编号 10285-06-0
    分子式 = 分子量 C15H25NO5 = 299.36
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Symphytum uplandicum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    印美定 CFN00285 10285-06-0 1mg QQ客服:2159513211
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    印美定 CFN00285 10285-06-0 10mg QQ客服:2159513211
    印美定 CFN00285 10285-06-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    Nature Plants. 2016 Dec 22;3: 16206.
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Agricultural Science2015, 1916-9760
  • Acta Physiologiae Plantarum2015, 37:1736
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Korean J. of Food Sci. and Tech2016, 172-177
  • J Ethnopharmacol.2016, 192:370-381
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  • Evid Based Complement Alternat Med.2017, 2017:7383104
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  • Cytotechnology.2017, 69(5):765-773
  • Industrial Crops and Products2017, 95:286-295
  • Nutrients.2018, 10(7)
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Microchemical Journal2018, 137:168-173
  • Phytochemistry2018, 15:83-92
  • Molecules.2018, 23(10):E2638
  • Molecules.2018, 23(7):E1817
  • Pathogens.2018, 7(3):E62
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Sci Rep.2018, 8:9267
  • J Ethnopharmacol.2019, 228:132-141
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • ...
  • 生物活性
    Description: Intermedin (IMD), a multi-functional peptide, plays important roles in cardiovascular protection, the endogenous IMD and its receptor complexes are induced in hypertrophic cardiomyocytes and proposed to play an important role in the pathogenesis of cardiac hypertrophy. Intermedin can decrease the melanin content of the skin of Rana pipiens.
    Targets: PI3K | PKA | MAPK | ERK | cAMP
    In vitro:
    Plos One, 2013, 8(8):e64757.
    Intermedin Suppresses Pressure Overload Cardiac Hypertrophy through Activation of Autophagy[Pubmed: 23737997]
    Left ventricular hypertrophy is a maladaptive response to pressure overload and an important risk factor for heart failure. Intermedin (Intermedine,IMD), a multi-functional peptide, plays important roles in cardiovascular protection.
    METHODS AND RESULTS:
    In this study, we revealed an autophagy-dependent mechanism involved in IMD’s protection against cardiac remodeling and cardiomyocyte death in heart hypertrophy. We observed that transverse aortic contraction (TAC) induction, Ang II or ISO exposure induced remarkable increase in the expression of endogenous IMD and its receptor components, CRLR, RAMP1 and RAMP3, in mouse hearts and H9c2 cell cultures, respectively. Furthermore, the heart size, heart weight/body weight ratios, cardiomyocyte size and apoptosis, interstitial collagen, hypertrophic markers including ANP and BNP expression were also significantly increased, which were effectively suppressed by IMD supplementation. In addition, IMD induced capillary angiogenesis and improved functions in hypertrophic hearts. We further observed that IMD induced strong autophagy in hypertrophic hearts and cultured cells, which was paralleling with the decrease in cardiomyocyte size and apoptosis. Furthermore, an autophagy inhibitor, 3-MA, was used to block the IMD-augmented autophagy level, and then the protection of IMD on cardiomyocyte hypertrophy and apoptosis was almost abrogated. We also observed that IMD supplementation stirred intracellular cAMP production, and augmented the ERK1/2 phosphorylation induced by Ang II/ISO exposure in H9c2 cells. In addition, we inhibited PI3K, PKA and MAPK/ERK1/2 signaling pathways by using wortamannin, H89 and PD98059, respectively, in H9c2 cells co-incubating with both IMD and Ang II or ISO, and observed that these inhibitors effectively reduced IMD-augmented autophagy level, but only H89 and PD98059 pre-incubation abrogated the anti-apoptotic action of IMD.
    CONCLUSIONS:
    These results indicate that the endogenous IMD and its receptor complexes are induced in hypertrophic cardiomyocytes and proposed to play an important role in the pathogenesis of cardiac hypertrophy, and the autophagy stirred by IMD supplementation is involved in its protection against cardiomyocyte hypertrophy and apoptosis through the activation of both cAMP/PKA and MAPK/ERK1/2 pathways.
    In vivo:
    Experientia, 1982,38(9):1085-1087.
    Pyrrolizidine alkaloids fromSymphytum officinale L. and their percutaneous absorption in rats[Reference: WebLink]
    .
    METHODS AND RESULTS:
    An analysis of a commercial sample of Symphyti radix originating from Poland with a total alkaloid content of 0.07% revealed the presence of 7 pyrrolizidine alkaloid-N-oxides: 7-acetyl Intermedine, 7-acetyl lycopsamine as the main constituents and lycopsamine, Intermedine, symphytine and traces of 2 further not yet identified alkaloids. The percutaneous absorption of these alkaloids was investigated in rats, using a crude alcoholic extract of the plant corresponding to a dose of 194 mg alkaloid-N-oxides/kg b.wt. The excretion of N-oxides in the urine during 2 days was in the range of 0.1–0.4% of the dose.
    CONCLUSIONS:
    The dermally absorbed N-oxides are not or only to a small extent converted to the free alkaloids in the organism. The oral application led to a 20–50 times higher excretion of N-oxides and free alkaloids in the urine.
    Proc Soc Exp Biol Med. 1951 May;77(1):35-7.
    Effect of administration of intermedin upon melanin content of the skin of Rana pipiens.[Pubmed: 14844386]

    METHODS AND RESULTS:
    The administration of intermedin(Intermedine), prepared from hog pituitary glands, results in a decrease, after four weeks, of twenty per cent in the melanin content of the skin of Rana pipiens. Subsequently, there is a rapid increase, reaching levels 40% above normal after a total of 8 weeks.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3405 mL 16.7023 mL 33.4046 mL 66.8092 mL 83.5115 mL
    5 mM 0.6681 mL 3.3405 mL 6.6809 mL 13.3618 mL 16.7023 mL
    10 mM 0.334 mL 1.6702 mL 3.3405 mL 6.6809 mL 8.3511 mL
    50 mM 0.0668 mL 0.334 mL 0.6681 mL 1.3362 mL 1.6702 mL
    100 mM 0.0334 mL 0.167 mL 0.334 mL 0.6681 mL 0.8351 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    印美定; Intermedine CFN00285 10285-06-0 C15H25NO5 = 299.36 5mg QQ客服:1413575084
    印美定N-氧化物; Intermedine N-oxide CFN00459 95462-14-9 C15H25NO6 = 315.4 5mg QQ客服:1413575084
    7-Acetylintermedine; 7-Acetylintermedine CFN00286 74243-01-9 C17H27NO6 = 341.40 5mg QQ客服:1413575084
    石松胺; Lycopsamine CFN00287 10285-07-1 C15H25NO5 = 299.37 5mg QQ客服:2932563308
    7-乙酰基印美定; 7-Acetyllycopsamine CFN00288 73544-48-6 C17H27NO6 = 341.40 5mg QQ客服:3257982914
    Petasinoside; Petasinoside CFN00277 70474-34-9 C28H37NO9 = 531.60 5mg QQ客服:215959384
    Thesinine; Thesinine CFN00278 488-02-8 C17H21NO3 = 287.36 5mg QQ客服:1413575084
    Ehretinine; Ehretinine CFN00282 76231-29-3 C16H21NO3 = 275.35 5mg QQ客服:2932563308
    大尾摇碱,印度天芥莱碱; Indicine CFN00283 480-82-0 C15H25NO5 = 299.36 5mg QQ客服:2932563308
    大尾摇碱-N-氧化物; Indicine N-oxide CFN00284 41708-76-3 C15H25NO6 = 315.37 5mg QQ客服:1148253675

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