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  • 草质素

    Herbacetin

    草质素
    产品编号 CFN99778
    CAS编号 527-95-7
    分子式 = 分子量 C15H10O7 = 302.24
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Equisetum hyemale L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    草质素 CFN99778 527-95-7 10mg QQ客服:215959384
    草质素 CFN99778 527-95-7 20mg QQ客服:215959384
    草质素 CFN99778 527-95-7 50mg QQ客服:215959384
    草质素 CFN99778 527-95-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mahatma Gandhi University (India)
  • Seoul National University of Science and Technology (Korea)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Kazusa DNA Research Institute (Japan)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Aarhus University (Denmark)
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Brasilia (Brazil)
  • Kamphaengphet Rajabhat University (Thailand)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of British Columbia (Canada)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Max Rubner-Institut (MRI) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • University of Central Lancashire2017, 20472
  • J Biochem Mol Toxicol.2017, 31(9)
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Nutrients.2018, 10(12):E1998
  • J Cell Biochem.2018, 119(2):2231-2239
  • Academic J of Second Military Medical University2018, 39(11)
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • J Mol Med (Berl).2018, 96(7):661-672
  • Phytother Res.2019, 10.1002
  • Nutr Metab (Lond).2019, 16:31
  • Molecules.2019, 24(16):E3003
  • Med Sci Monit.2019, 25:9499-9508
  • Food Chem.2019, 274:345-350
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Pharmacol Rep.2019, 71(2):289-298
  • Process Biochemistry2019, 87:213-220
  • Sci Rep.2019, 9(1):6429
  • Appl. Sci.2020, 10,1304
  • J Cell Physiol.2020, 10.1002
  • Food Research International2020, 108987
  • Plant Cell Tiss Org2020, 1-16
  • ...
  • 生物活性
    Description: Herbacetin, a novel Met inhibitor with a potential utility in cancer therapeutics, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators. Herbacetin also has a strong ability to scavenge free radical and inhibit oxidative protein damage.
    Targets: NO | TNF-α | JNK | ERK | NF-kB | NOS | p38MAPK | Akt | ROS | PARP | PI3K | Caspase
    In vitro:
    Eur J Pharmacol. 2015 Oct 15;765:115-23.
    Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells.[Pubmed: 26297979 ]
    Herbacetin (3,4',5,7,8-pentahydroxyflavone), an active flavonol compound within flavonoid, has been shown to induce apoptosis in HepG2 cells and suppress hepatocyte growth factor-induced motility of human breast cancer MDA-MB-231 cells. However, the anti-inflammatory mechanisms of Herbacetin have not been researched.
    METHODS AND RESULTS:
    In this study, we examined the inflammatory responses stimulated by lipopolysaccharide (LPS) in RAW264.7 macrophage cells after pretreatment with different concentrations of Herbacetin. We found that Herbacetin decreased nitric oxide (NO) production in LPS-induced RAW264.7 and mouse bone marrow-derived macrophages. In addition, Herbacetin inhibited the LPS-induced expression of inducible nitric oxide synthase mRNA and protein in RAW264.7 cells. Treatment with Herbacetin decreased the release of proinflammatory cytokines, including TNF-α and IL-1β. Moreover, Herbacetin inhibited the activity of JNK kinase and nuclear factor-κB, signaling molecules involved in NO production. Cell signaling analysis using Bay 11-7082 (an inhibitory κB kinase 2 inhibitor) and mitogen-activated protein kinase (MAPK) inhibitors (SB203580 for p38, SP600125 for JNK, and PD 98059 for ERK) suggested that LPS induced iNOS expression via activation of the JNK and NF-κB pathway, but not the p38 and ERK pathway.
    CONCLUSIONS:
    These findings suggest that Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators.
    Planta Med. 2013 Nov;79(16):1525-30.
    Herbacetin, a constituent of ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.[Pubmed: 24081687]
    Ephedrae herba suppresses hepatocyte growth factor-induced cancer cell motility by inhibiting tyrosine phosphorylation of the hepatocyte growth factor receptor, c-Met, and the PI3K/Akt pathway. Moreover, Ephedrae herba directly inhibits the tyrosine-kinase activity of c-Met. Ephedrine-type alkaloids, which are the active component of Ephedrae herba, do not affect hepatocyte growth factor-c-Met-Akt signalling, prompting us to study other active molecules in the herb.
    METHODS AND RESULTS:
    We recently discovered herbacetin glycosides and found that their aglycon, herbacetin, inhibits hepatocyte growth factor-c-Met-Akt signalling. This study revealed a novel biological activity of herbacetin. Herbacetin suppressed hepatocyte growth factor-induced motility in human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation and directly inhibiting c-Met tyrosine kinase activity. The effects of herbacetin were compared to those of kaempferol, apigenin, and isoscutellarein, all of which have similar structures. Herbacetin inhibition of hepatocyte growth factor-induced motility was the strongest of those for the tested flavonols, and only herbacetin inhibited the hepatocyte growth factor-induced phosphorylation of c-Met.
    CONCLUSIONS:
    These data suggest that herbacetin is a novel Met inhibitor with a potential utility in cancer therapeutics.
    Food Science, 2013, 34(17):106-10.
    In vitro Free Radical Scavenging and Protein Oxidation Inhibitory Effects of Herbacetin[Reference: WebLink]

    METHODS AND RESULTS:
    The in vitro antioxidant activity of Herbacetin was investigated in terms of scavenging activities against DPPH and hydroxyl free radicals and inhibitory effects against oxidative protein damage and carbonylation induced by Cu 2+-H 2 O 2 or AAPH. At a concentration between 10 μ mol/L and 100 μ mol/L, Herbacetin exerted a marked scavenging effect on DPPH and hydroxyl free radicals, with respective IC 50 values of 49.28 μ mol/L and 219.2 μ mol/L. Meanwhile, Herbacetin could significantly inhibit oxidative protein damage and carbonylation induced by Cu 2+-H 2 O 2 or AAPH in a dose-dependent manner.
    CONCLUSIONS:
    This study concludes that Herbacetin has a strong ability to scavenge free radical and inhibit oxidative protein damage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3086 mL 16.5431 mL 33.0863 mL 66.1726 mL 82.7157 mL
    5 mM 0.6617 mL 3.3086 mL 6.6173 mL 13.2345 mL 16.5431 mL
    10 mM 0.3309 mL 1.6543 mL 3.3086 mL 6.6173 mL 8.2716 mL
    50 mM 0.0662 mL 0.3309 mL 0.6617 mL 1.3235 mL 1.6543 mL
    100 mM 0.0331 mL 0.1654 mL 0.3309 mL 0.6617 mL 0.8272 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4',7-三乙酰山奈酚; 3,4',7-三乙酸堪非醇酯; Kaempferol 3,4,7-triacetate CFN99479 143724-69-0 C21H16O9 = 412.4 5mg QQ客服:3257982914
    四乙酰山奈酚; 四乙酸堪非醇酯; Kaempferol tetraacetate CFN99686 16274-11-6 C23H18O10 = 454.4 5mg QQ客服:1148253675
    异山柰素; Isokaempferide CFN93002 1592-70-7 C16H12O6 = 300.3 5mg QQ客服:1148253675
    5-甲氧基山奈酚; 5-甲氧基莰非醇; Kaempferol 5-methyl ether CFN92510 22044-80-0 C16H12O6 = 300.3 5mg QQ客服:2159513211
    鼠李柠檬素; Rhamnocitrin CFN97724 569-92-6 C16H12O6 = 300.27 5mg QQ客服:2932563308
    山奈素; Kaempferide CFN98782 491-54-3 C16H12O6 = 300.3 20mg QQ客服:1148253675
    华良姜素;熊竹素; Kumatakenin CFN98423 3301-49-3 C17H14O6 = 314.3 10mg QQ客服:2159513211
    3,5-二羟基-4',7-二甲氧基黄酮; 3,5-Dihydroxy-4',7-dimethoxyflavone CFN99651 15486-33-6 C17H14O6 = 314.3 5mg QQ客服:1413575084
    堪非醇3,4'-二-O-甲醚; Ermanin CFN98050 20869-95-8 C17H14O6 = 314.3 10mg QQ客服:2932563308
    莰非醇-3,7,4'-三甲醚; Kaempferol 3,7,4'-trimethylether CFN96191 15486-34-7 C18H16O6 = 328.3 10mg QQ客服:2159513211

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