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  • 莰非醇-3,7,4'-三甲醚

    Kaempferol 3,7,4'-trimethylether

    莰非醇-3,7,4'-三甲醚
    产品编号 CFN96191
    CAS编号 15486-34-7
    分子式 = 分子量 C18H16O6 = 328.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The rhizomes of Curcuma aromatica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 1mg QQ客服:2932563308
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 5mg QQ客服:2932563308
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 10mg QQ客服:2932563308
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Complutense University of Madrid (Spain)
  • Utah State University (USA)
  • University of Maryland (USA)
  • University of Medicine and Pharmacy (Romania)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Auckland (New Zealand)
  • Univerzita Karlova v Praze (Czech Republic)
  • University Medical Center Mainz (Germany)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Universidade do Porto (Portugal)
  • University of Fribourg (Switzerland)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • National Cancer Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Tumour Biol.2015, 36(9):7027-34
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Chemistry of Plant Materials.2016, 33-46
  • Mol Immunol. 2016, 78:121-132
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Front Plant Sci.2017, 8:723
  • Drug Test Anal.2018, 10(10):1579-1589
  • Microchemical Journal2018, 137:168-173
  • Nat Chem Biol.2018, 14(8):760-763
  • Phytochemistry2018, 15:83-92
  • Nat Prod Sci.2018, 24(2):109-114
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Planta Med.2018, 84(15):1101-1109
  • J Pharm Biomed Anal.2019, 172:268-277
  • J Ethnopharmacol.2019, 236:31-41
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Environ Toxicol.2019, 34(12):1354-1362
  • Sci Rep.2019, 9(1):6429
  • Oxid Med Cell Longev2020, 12
  • Pharmacological Reports2020, 1-9
  • Journal of Chromatography A2020, 460942
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
    Targets: NO
    In vitro:
    BMC Complement Altern Med. 2014 Sep 19;14:340.
    Cytotoxicity of four Aframomum species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) towards multi-factorial drug resistant cancer cell lines.[Pubmed: 25239700 ]
    The search for natural products as potential cytotoxic agents has yielded promising candidates. However multidrug resistance (MDR) is still a major hurdle for patients receiving chemotherapy. In the present study, we evaluated the cytotoxicity of the methanol extracts of four dietary Aframomum plant species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) against nine sensitive and MDR cancer cell lines. We have also identified the bioactive constituents of A. arundinaceum.
    METHODS AND RESULTS:
    The cytotoxicity of the methanol extracts of the above plants was determined using a resazurin reduction assay. Chromatographic techniques were used to isolate the constituents of A. arundinaceum. A preliminary experiment on leukemia CCRF-CEM cells at 40 μg/mL showed that the extracts from A. kayserianum and A. alboviolaceum as well as the isolated compounds namely compounds aframodial (1), 8(17),12-labdadien-15,16-dial (2), galanolactone (3), 1-p-menthene-3,6-diol (6) and 1,4-dimethoxybenzene (7) were less active, inducing more than 50% growth of this cell line contrary to A. polyanthum and A. arundinaceum extracts, galanals A (4) and B (5), naringenin (8) and Kaempferol 3,7,4'-trimethylether (9). The IC50 values below or around 30 μg/mL were recorded with A. arundinaceum extract against eight of the nine tested cancer cell lines. This extract as well as compound 8 displayed IC50 values below 40 μg/mL towards the nine tested cancer cell lines whilst A. polyanthum extract, compounds 4, 5 and 9 showed selective activities. Collateral sensitivity (hypersensitivity) was observed with A. arundinaceum extract towards leukemia CEM/ADR5000 cells and glioblastoma U87MG.ΔEGFR compared to their respective sensitive counterparts CEM/CEM and U87MG.
    CONCLUSIONS:
    The results of this study provide evidence of the cytotoxicity selected Aframomum species as well as a baseline information for the potential use of Aframomum arundinaceum in the fight against drug sensitive and otherwise drug-resistant cancers.
    Songklanakarin Journal of Science and Technology, 2013, 35,(3): 317-23.
    Inhibition of nitric oxide production by compounds from Boesenbergia longiflora using lipopolysaccharide-stimulated RAW264.7 macrophage cells[Reference: WebLink]

    METHODS AND RESULTS:
    The inhibitory activity of extract and compounds isolated from Boesenbergia longiflora against nitric oxide (NO) was evaluated using RAW264.7 cells. Isolation of the chloroform extract of B. longiflora rhizomes afforded four known flavonoids, which were identified as Kaempferol 3,7,4'-trimethylether (1), kaempferol-7,4'-dimethyl ether (2), rhamnazin (3), pinostrobin (4), together with four known diarylheptanoids, dihydrobisdemethoxycurcumin (5), curcumin (6), demethoxycurcumin (7) and bisdemethoxycurcumin (8), as well as one sterol, -sitosterol-D-glucoside (9). Compound 6 exhibited the highest inhibitory activity against NO release with an IC50 value of 4.5 μM, followed by 7 (IC50 = 11.7 μM), 8 (IC50 = 15.7 μM), 5 (IC50 = 23.0 μM) and 1 (IC50 = 23.5 μM), respectively.
    CONCLUSIONS:
    This study demonstrated that diarylheptanoids and some methoxyflavonoids found in B. longiflora are responsible for anti-inflammatory activity and this is the first report the safety, chemical constituents and biological activity of this plant.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.046 mL 15.23 mL 30.4599 mL 60.9199 mL 76.1499 mL
    5 mM 0.6092 mL 3.046 mL 6.092 mL 12.184 mL 15.23 mL
    10 mM 0.3046 mL 1.523 mL 3.046 mL 6.092 mL 7.615 mL
    50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2184 mL 1.523 mL
    100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.6092 mL 0.7615 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',5,7-三羟基 3,6,8-三甲氧基黄酮; 4',5,7-Trihydroxy 3,6,8-trimethoxyflavone CFN70413 57393-71-2 C18H16O8 = 360.3 5mg QQ客服:1413575084
    Calycopterin; Calycopterin CFN70374 481-52-7 C19H18O8 = 374.4 5mg QQ客服:215959384
    5,7-二羟基-3,4',6,8-四甲氧基黄酮; Araneosol CFN98797 50461-86-4 C19H18O8 = 374.4 5mg QQ客服:3257982914
    2',3,5,7-四羟基黄酮; 2',3,5,7-Tetrahydroxyflavone CFN70373 480-15-9 C15H10O6 = 286.2 5mg QQ客服:2932563308
    山奈酚; Kaempferol CFN98838 520-18-3 C15H10O6 = 286.2 20mg QQ客服:1148253675
    3,4',7-三乙酰山奈酚; 3,4',7-三乙酸堪非醇酯; Kaempferol 3,4,7-triacetate CFN99479 143724-69-0 C21H16O9 = 412.4 5mg QQ客服:1413575084
    四乙酰山奈酚; 四乙酸堪非醇酯; Kaempferol tetraacetate CFN99686 16274-11-6 C23H18O10 = 454.4 5mg QQ客服:1148253675
    异山柰素; Isokaempferide CFN93002 1592-70-7 C16H12O6 = 300.3 5mg QQ客服:1413575084
    5-甲氧基山奈酚; 5-甲氧基莰非醇; Kaempferol 5-methyl ether CFN92510 22044-80-0 C16H12O6 = 300.3 5mg QQ客服:1413575084
    鼠李柠檬素; Rhamnocitrin CFN97724 569-92-6 C16H12O6 = 300.27 5mg QQ客服:1148253675

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